Windshield pitting incidents in Washington reach fever pitch on April 15, 1954 (2003) • Hacker News Board

Re: Windshield pitting incidents in Washington reach fever pitch on April 15, 1954 (2003)

#321

Post by mvkel » Sat, Dec 21, 2024, 3:38 AM UTC

Aloisius wrote: post #141

mvkel wrote: post #80

Earlier quoted context omitted.

Slippery slope. I posit that there are news items that deserve real cause for concern, but because we're so overwhelmed with information, we throw it into the same "gossip" bucket with the rest of the slop.

Few news items ever rise to that level and fewer still deserve immediate attention. Daily news is merely a first rough draft of history and I'd argue most people would be better off instead reading later drafts - after much of the confusion/gossip/rumor/panic that plagues daily news clears. Sadly there's not a lot of news sources that limit themselves to writing articles about month+ old well-covered news.

> Daily news is merely a first rough draft of history

Love this.

Re: Windshield pitting incidents in Washington reach fever pitch on April 15, 1954 (2003)

#322

Post by NavinF » Sat, Dec 21, 2024, 7:34 AM UTC

SanDiegoSun wrote: post #188

NavinF wrote: post #172

Earlier quoted context omitted.

meth vs adderall is more about dosage. If for some reason you decided to consume massive amounts of adderall the same way crazy homeless people consume meth (1000mg instead of 30mg), you could get addicted to it. Pretty much nobody does this with adderall, but the theory is solid. See https://www.astralcodexten.com/p/drug-users-use-a-lot-of-dru... > Despite the repeated claims of METH being more addictive or preferre…

> The psychostimulants d-amphetamine (AMPH) and methamphetamine (METH) release excess dopamine (DA) into the synaptic clefts of dopaminergic neurons. Abnormal DA release is thought to occur by reverse transport through the DA transporter (DAT), and it is believed to underlie the severe behavioral effects of these drugs. Here we compare structurally similar AMPH and METH on DAT function in a heterologous expression sy…

1. Why make claims about 5x dopamine and 2x Ca2+ instead of just scoring how people respond to the drug at various dosage?

2. None of that is relevant. I'm talking about people taking >30x the dose, not 5x lol. Do you have a background in pharmacology and not understand how that would make a difference?

Re: Windshield pitting incidents in Washington reach fever pitch on April 15, 1954 (2003)

#323

Post by anothertroll123 » Sat, Dec 21, 2024, 5:34 PM UTC

WalterBright wrote: post #284

bregma wrote: post #267

Earlier quoted context omitted.

Some men have honor. FTFY

Those without honor are intelligent animals, but not men. Each of us makes that choice for ourselves.

[dead]

Re: Windshield pitting incidents in Washington reach fever pitch on April 15, 1954 (2003)

#324

Post by kaffekaka » Sun, Dec 22, 2024, 7:09 PM UTC

sethherr wrote: post #293

kaffekaka wrote: post #292

Earlier quoted context omitted.

As far as I know the progression into sub 4 minute miles was quite linear and not some kind of sudden breach once everybody understood it was at all possible. The story of a sudden breach is perhaps more attractive though.

From wikipedia's 4 minute mile article - https://en.wikipedia.org/wiki/Four-minute_mile > The four-minute barrier was first broken on 6 May 1954 at Oxford University's Iffley Road Track, by British athlete Roger Bannister > On 21 June 1954, at an international meet at Turku, Finland, Australia's John Landy became the second man, after Bannister, to achieve a sub-four-minute mile. In 1955 Laszlo Tabori was the third p…

I read this one: https://www.scienceofrunning.com/2017/05/the-roger-bannister...

With for example: "What this shows us is that the issue wasn’t massively psychological. If it was, we would have seen athletes running 1,500m races much faster than their corresponding mile time. Instead, we see that the progression matches up nicely. People were stuck on 4 minutes at the same time they were stuck on 3:43. Do we really think that runners were stuck on a mythical 3:43.0 barrier?"

In case you don't want to read it, it says that other distances had similar "breakthroughs" but they were not associated with a mental barrier like "4 minute mile". Rather, the article argues, the development may have been related to WW2.

Edit: it just so happened that for mile running, the stagnation after WW2 occured just around the four minute mark. You need to look at other distances and perhaps even other sports to see the pattern.

Indeed, my country Sweden won the olympic football/soccer in 1948 - a result widely regarded as being due to other countries have sent all their young men to the war while Sweden stayed neutral/did not fight the germans.

Re: Windshield pitting incidents in Washington reach fever pitch on April 15, 1954 (2003)

#325

Post by SanDiegoSun » Sun, Dec 29, 2024, 11:01 PM UTC

NavinF wrote: post #322

SanDiegoSun wrote: post #188

Earlier quoted context omitted.

> The psychostimulants d-amphetamine (AMPH) and methamphetamine (METH) release excess dopamine (DA) into the synaptic clefts of dopaminergic neurons. Abnormal DA release is thought to occur by reverse transport through the DA transporter (DAT), and it is believed to underlie the severe behavioral effects of these drugs. Here we compare structurally similar AMPH and METH on DAT function in a heterologous expression sy…

1. Why make claims about 5x dopamine and 2x Ca2+ instead of just scoring how people respond to the drug at various dosage? 2. None of that is relevant. I'm talking about people taking >30x the dose, not 5x lol. Do you have a background in pharmacology and not understand how that would make a difference?

Your source claimed no provable increase in potency. This refutes that.

Of course a higher dosage of a more potent drug will lead to wildly different and markedly increased effects... I think you have your argument wrapped in semantic reasoning rather than pharmacology.

Beyond this, do you admit your premise is flawed?