321–330 of 389 posts
Earlier quoted context omitted.
Just waiting for first copy protection mechanism for mRNA. SafeGene and SecuGene here we come :o
Can you imagine, the greedy folk would want some sort of Widevine in humans.
The Human Genome Project was completed almost two decades ago, and somebody solved the protein folding problem recently. Why are we still doing genetics at the machine code level? Shouldn't we have some compilers, assemblers and linkers by now?
Earlier quoted context omitted.
> put together their sequences in a weekend meh, I could do that over a weekend never sounded so scary, or impressive at the same time. That weekend just so happened to stand on the shoulders of prior decades of research though. i guess this is big pharma's version of `apt-get install`
Modern a has been working on mRNA since 2010 and mRNA vaccines since 2012. They have the process down pretty solid, but vaccines do not bring in the bacon.
https://github.com/bionicles/coronavirus
to make the trie use the function here. the variable K is the length of the Kmers (runs of RNA). Larger values are gonna take a lot longer. ( warning: big job, uses multiprocessing...pypy recommended for speed ) https://github.com/bionicles/coronavirus/blob/b6f0db9dd8aaf7...
then you could use this recursive function to generate potential matches within some cutoff https://github.com/bionicles/coronavirus/blob/b6f0db9dd8aaf7...
the function right below it converts the generator to a list. then you could save that
enjoy
So you have a header/footer sequence that we sort of know is required (remember the MZ and chksum for .EXE files) but we have no idea what that bits in between does except we can read the letters and copied it in part from the actual virus.
Earlier quoted context omitted.
Here you go! https://github.com/brianherman/Assemblies-of-putative-SARS-C...
If there is no annotation or metadata FASTA format is usually preferred ;)
I'm sure it's more complex than I grasp as a layperson, but I'm utterly amazed at how simple this _appears_. I get the feeling that this is something I have a better chance of understanding than the average SaaS Terms and Conditions. I expected to have to scroll through pages upon pages of indecipherable text. Instead it's no bigger than a large paragraph of text, and I can easily fit it on my screen.
The protein they're trying to manufacture is indeed quite simple - AFAIU both BioNTech and Moderna put together their sequences in a weekend. (Though there was a more involved process of winnowing down the sequences for the most effective ones.) The technically challenging parts are: - delivery mechanism: you need to take a very unstable molecule, protect it from the environment - both external, and when inside the p…
The most amazing thing is that now that the platform is proven secure in dozens of millions of people, it should be be very easy and fast to get approval for other payloads. Biontech for example wants to go after cancers - a platform that can deliver payloads targeted to an individual's cancer is nothing short of a game changer in cancer treatment because the current standard of blasting the patient's body with a lot of highly toxic chemicals is arcane compared to letting the body's immune system do the cleanup.