Reminded me of Warcraft (the first), where, if you kept clicking on the same unit they would respond in more annoyed ways. The best IMHO was the human soldier[1], which would end with "Why do you keep touching me?". First game that I knew of which had such fun details like that. [1]: https://www.youtube.com/watch?v=jaZyZZtwdzQ
Annoyed Death Knight: "When my work is finished, I'm coming back for you..."