Live data from Hacker News

Ozempic shows anti-aging effects in trial

trial.medpath.com

311–320 of 868 posts

Re: Ozempic shows anti-aging effects in trial

#311

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

In part that's because historically weight loss drugs have had nasty side effects that only become apparent after years of use.

Re: Ozempic shows anti-aging effects in trial

#312

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

It's similar to the hate that some people have for SSRIs when they've never tried one.

Re: Ozempic shows anti-aging effects in trial

#313
post #68
post #54

Earlier quoted context omitted.

I was kind of scared of these when Ozempic starting picking of steam for weight loss. I was worried that this would be having more negative effects. Turns out, generally speaking, if used with you doctor, these things are pretty safe, especially comparatively to some of the negatives of being overweight. And then I saw some of the stories on HN about how it's changed peoples lives for the better. And then people in m…

And not just weight loss, but the people I know on GLP-1's have also significantly cut back on alcohol. I think there are ongoing trials around GLP-1's and general addiction.

Definitely lowered alcohol consumption for me.

I no longer get that dopamine rush of the first drink.

Some people go as far as describing it as anhedonia. I kinda get it.

Re: Ozempic shows anti-aging effects in trial

#314

Earlier quoted context omitted.

[flagged]

Doctors don’t get paid for writing prescriptions. They don’t get kickbacks for writing prescriptions. A small subset of doctors are paid by pharmaceutical companies to run trials or provide expertise, but you can look that up since it’s publicly available information, and it’s not based on them prescribing you anything. At most a drug rep comes by and brings donuts or something to talk about their new drugs. Source w…

Huh? Drug reps have scorecards for the doctors they call on and throw perks at the top performers or influencers. It also depends on the speciality - dermatologists working for price equity mills are almost evaluated like salespeople. Source: girlfriend is a rep.

Re: Ozempic shows anti-aging effects in trial

#315
post #139

Earlier quoted context omitted.

I've heard similar for gambling, and as one of the sister comments said, things like video games. I'm so curious to understand _why_ that effect is there, but I've heard this so many times now that I do believe that it exists in some capacity. Such an interesting world we're opening up here.

Every person I know who tried to give up smoking has the same story - they were successful for a while and then they encountered some stressful moment (exam, work deadline, etc) and they fell off the wagon. One explanation could simply be that normally we have food stresses which manifests in general stress which we relieve via video games or whatever else. If these drugs turn down the volume of hunger then maybe thi…

I’ve taken a GLP for two years. It resets your dopamine reward system. It helped me lose 80 lbs and I’m running now. Zero craving for alcohol and sugar. But, my libido is like 3x lol.

If some rando internet dude thinks I’m weak or stupid, fine with me. It’s a drug that has improved my life in ways that are difficult to describe.

Re: Ozempic shows anti-aging effects in trial

#316
post #302

Earlier quoted context omitted.

Doctors don’t get paid for writing prescriptions. They don’t get kickbacks for writing prescriptions. A small subset of doctors are paid by pharmaceutical companies to run trials or provide expertise, but you can look that up since it’s publicly available information, and it’s not based on them prescribing you anything. At most a drug rep comes by and brings donuts or something to talk about their new drugs. Source w…

My dad got box seats to a hockey game when I was a wee lad so theyll sometimes throw money at docs

Thanks to Obama and the Sunshine Act, this basically never happens anymore.

https://www.mdlinx.com/article/a-physician-s-guide-to-accept...

Increased reporting requirements and a cap on the value of these gifts that is far too low for box seats.

My wife's a physician, and I've seen these things change dramatically. Sometimes some food for the whole office will get dropped off. Or donuts. No one's getting box seats to a pro sports game anymore.

Re: Ozempic shows anti-aging effects in trial

#317
post #302

Earlier quoted context omitted.

Doctors don’t get paid for writing prescriptions. They don’t get kickbacks for writing prescriptions. A small subset of doctors are paid by pharmaceutical companies to run trials or provide expertise, but you can look that up since it’s publicly available information, and it’s not based on them prescribing you anything. At most a drug rep comes by and brings donuts or something to talk about their new drugs. Source w…

My dad got box seats to a hockey game when I was a wee lad so theyll sometimes throw money at docs

The rules changed around a decade ago to limit the amount of gifts a doctor could receive from pharmaceutical companies.

Re: Ozempic shows anti-aging effects in trial

#318

Earlier quoted context omitted.

Adderall produces a very, very different experience and is prescribed to address a very, very different root cause.

However, amphetamines such as Adderall were also sometimes prescribed for weight loss. I'm surprised it was done so rarely before Ozempic was a thing. They were quite effective.

Stimulants have well documented downsides. It’s one of the hard aspects for adults with adhd as you often need to taper as you develop heart issues.

Re: Ozempic shows anti-aging effects in trial

#319
post #157

Earlier quoted context omitted.

No but its a lot easier for people who've had trouble and gets results, which is all that matters.

Heroine would also help them lose weight also. Maybe cocaine too, but I'm not sure. So it's not "all that matters". What matters is, are the negative side effects and long term consequences better for you than the alternatives. One of them is "remaining fat". The other is "doing what other people have proven works.. cut all carbs".

You are showing your own ass with this ridiculous analogy. What are the negative effects of ozempic? Because the negative effects of heroin (not "heroine") and cocaine are well known and grossly outweigh "not being fat."

Is ozempic worse than being fat?

Re: Ozempic shows anti-aging effects in trial

#320
post #253

Earlier quoted context omitted.

I don't understand. What's sad about giving up junk carbs?

Bread, sugar and potatoes exist on a spectrum from highly processed/refined (truly problematic) to minimally processed whole food versions (nutritionally valuable). There's no reason to give up minimally processed whole food versions of these.

What a bizarre, illogical comment. Did you even read what @throwawaylaptop wrote above? While most of us can handle she carbs just fine, some people have to pretty much eliminate them (regardless of processing level) in order to lose fat.
Post reply on HN