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Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

medicalxpress.com

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Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#311

Post by nextos »

scarmig wrote: post #277
vlovich123 wrote: post #179

Earlier quoted context omitted.

> The study would not have been possible without the use of artificial intelligence to weed through dozens of proteins in a class called prohormones. I see we’re being fast and loose with the term “artificial intelligence”?

Regexes were invented by Kleene in 1951, to describe McCulloch-Pitts neural nets. So, artificial intelligence! https://www.rand.org/content/dam/rand/pubs/research_memorand...

Jokes aside regexes being AI, lots of protein motifs can be elegantly described by simple regexes. And their classification performance is sometimes perfect.

See the Eukaryotic Linear Motif resource: http://elm.eu.org/elms.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#312

Post by crazygringo »

im3w1l wrote: post #214
crazygringo wrote: post #152

Earlier quoted context omitted.

But my point is that this is no different from being skinny and frail in the first place . It has nothing to do with losing weight. Yes, that puts you at risk. That's why you should exercise, even if it just means daily walks. The point is, you're not winding up with too little muscle because you lost weight. If you're winding up with too little muscle, it's because you're not being physically active enough. If you'r…

> The point is, you're not winding up with too little muscle because you lost weight Imagine someone eating only candy and pastries, but because they eat so huge amounts, they actually get a half-decent amount of protein. Then they decrease portion size with the help of appetite suppresants.

I explicitly made clear in my original comment:

> Provided you are eating enough protein, but that's easy.

If you're trying to lose weight eating only candy and pastries, then we're having an entirely different conversation...

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#313

Post by crazygringo »

sn9 wrote: post #248
crazygringo wrote: post #133

Earlier quoted context omitted.

> but rather you lose muscle mass all over. Well, you lose weight all over. You lose fat in your arms and your shoulders don't need to be quite as strong. You lose weight on your face and your neck muscles don't need to be quite as strong. You lose more in your legs, but you're supposed to lose muscle mass all over. > Someone relying on a GLP-1 drug is often someone who isn't very active at all. Sure, but that's a co…

Spot reduction of fat is a myth.

OK? Nobody's talking about that?

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#314

Post by TheRealPomax »

Der_Einzige wrote: post #212
TheRealPomax wrote: post #150

Earlier quoted context omitted.

Function documentation goes inside functions in Python, explicitly making them self-documenting. That can then be automatically picked up by any other code (like tooling for automatically generating API documentation) formalized as PEP 257, https://peps.python.org/pep-0257 Python will literally assign the content of your docstring (a triple-quoted string at the start of a function) to a special double underscored ("d…

How is this not more well known? I thought I was a god for discovering dir() but you’re showing that I was nothing but a peon!!!

There's a bunch of "all dunder properties" pages online, any one of them is well worth reading through at least once. So much hidden goodness.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#315

Post by TheRealPomax »

Izkata wrote: post #280
TheRealPomax wrote: post #150

Earlier quoted context omitted.

Function documentation goes inside functions in Python, explicitly making them self-documenting. That can then be automatically picked up by any other code (like tooling for automatically generating API documentation) formalized as PEP 257, https://peps.python.org/pep-0257 Python will literally assign the content of your docstring (a triple-quoted string at the start of a function) to a special double underscored ("d…

> Python will literally assign the content of your docstring (a triple-quoted string at the start of a function) Any string. Triple-quoted is just multiline strings and works anywhere.

True, I forget some people think a single line is function documentation; any function that's worth documenting is worth documenting properly, and needs multiline ;)

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#316

Post by sizzle »

thayne wrote: post #185

Since it is naturally occurring, it isn't patentable. Which means it is less likely that companies will develop a commercial product from it. Why pay to get FDA approval, if you don't get a government granted monopoly on it afterwards? This is one problem with using patents as the mechanism to incentivise development of medicine.

Pretty sure this would help save health insurance companies and Medicare billions if it’s a relatively safe defense against obesity and related mortality. There could be a push to get it to market from Medicare? Anyone want to comment with more knowledge of how it could be funded by the government? Note: The current administration is gutting the NIH so those programs and grants are shrinking

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#318

Post by hahajk »

AlwaysRock wrote: post #204
vlovich123 wrote: post #179

Earlier quoted context omitted.

> The study would not have been possible without the use of artificial intelligence to weed through dozens of proteins in a class called prohormones. I see we’re being fast and loose with the term “artificial intelligence”?

AI is the new, “Algorithm”. It is an overly broad term that basically means, “Technology” to people who use it.

My understanding is that the original use of AI was to describe algorithms that solved complicated problems, but only sometimes, and usually through heuristics. As opposed to provably correct algorithms like Dijkstra's.

I think that's how we still use it.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#319

Post by JumpCrisscross »

thayne wrote: post #185

Since it is naturally occurring, it isn't patentable. Which means it is less likely that companies will develop a commercial product from it. Why pay to get FDA approval, if you don't get a government granted monopoly on it afterwards? This is one problem with using patents as the mechanism to incentivise development of medicine.

> Since it is naturally occurring, it isn't patentable

Supplements are a $50bn business [1].

[1] https://www.grandviewresearch.com/industry-analysis/us-dieta...

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#320

Post by JumpCrisscross »

Der_Einzige wrote: post #217
derektank wrote: post #115

Earlier quoted context omitted.

Exercise is great for your health, but it generally has a negligible effect on weight loss because exercise doesn't actually consume that many calories. The biggest benefit of exercise on weight loss is the temporary exercise-induced anorexia that occurs in very high intensity workouts.

You are so full of shit. I get on the treadmill for 1 hour and consume 700 calories in that hour. Heavy exercise also causes improved appetite and sleep regulation as it fixes your blood sugar levels. This leads to your demand for food and especially the worst kinds to paradoxically go down for most fat people (they were already eating too many calories) Calories in and calories out shows that I will durably lose wei…

> Calories in and calories out

This is sort of like trying to fly a plane using Newtonian physics. Like, you can do it. But it’s more an exercise in pedantry than practicality.

My body, for example, loves to frivol away weight. I can eat like a pig and lounge around and my basal metabolism will spike and I won’t gain weight (nor lose much strength, though I do lose definition). Similar for people with metabolic syndrome: their bodies will literally start starving themselves by cutting basal metabolism in reaction to less food or more exertion before they’ll give up some fat cells. Not everyone who is obese has metabolic syndrome. But you’re going against the science if you insist all we need is diet and exercise education.

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