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Widely used chemical strongly linked to Parkinson’s disease

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Re: Widely used chemical strongly linked to Parkinson’s disease

#311

Earlier quoted context omitted.

...and as an inhaled surgical anesthetic for children As one who went under inhaled anesthesia a dozen times or more as a child in the 70s, I can only say, "WTF?" It makes a great solvent, so let's put in anesthesia?

as an inhaled surgical anesthetic for children and women in labor To be fair though, the restricted audience for the administration of this particular chemical would seem to indicate considerations of safety have been applied, otherwise one would expect a more general pattern. One must suspect there are many more chemicals with similarly hard-to-test-for longterm effects in daily use, note especially the so-called 'f…

I had a couple of operations as a youngster, and from my memory (could be faulty) they would speak to you while you were still on the trolley then waft some gas in front of you as you needed to breathe in. Then, when you were sedated they would get on with the business. I guess they would be able to inject you with something a bit more serious without you squirming, and transfer you to the table etc..

Re: Widely used chemical strongly linked to Parkinson’s disease

#312
post #277

Earlier quoted context omitted.

Yeah, automotive brake cleaner comes to mind. Proven to cause neurological damage, horrifically acutely toxic and chronically toxic, causes colorblindness of all things... Oh yeah, when it thermally decomposes into phosgene, a WWI-era chemical weapon. Spray brake cleaner on hot brakes and you're pretty much instantly dead.

>Spray brake cleaner on hot brakes and you're pretty much instantly dead. brake cleaner is bad -- i'm not here to dispute that -- but i've witnessed quick-lube/inspection mechanics spraying brake cleaner onto hot brakes for 20+ years, both in shops i've worked in personally and in shops i've witnessed as a customer. Oil-lube guys routinely work on very hot just-off-the-highway cars. Brake inspections are often a requ…

I wouldn't be surprised if the wanton use of brake cleaner you describe was using the non-chlorinated variety. Both exist, e.g.:

https://www.amazon.com/CRC-05089-BRAKLEEN-Brake-Cleaner/dp/B... vs https://www.amazon.com/CRC-05089-BRAKLEEN-Brake-Cleaner/dp/B...

Re: Widely used chemical strongly linked to Parkinson’s disease

#313
post #277

Earlier quoted context omitted.

>Spray brake cleaner on hot brakes and you're pretty much instantly dead. brake cleaner is bad -- i'm not here to dispute that -- but i've witnessed quick-lube/inspection mechanics spraying brake cleaner onto hot brakes for 20+ years, both in shops i've worked in personally and in shops i've witnessed as a customer. Oil-lube guys routinely work on very hot just-off-the-highway cars. Brake inspections are often a requ…

I wouldn't be surprised if the wanton use of brake cleaner you describe was using the non-chlorinated variety. Both exist, e.g.: https://www.amazon.com/CRC-05089-BRAKLEEN-Brake-Cleaner/dp/B... vs https://www.amazon.com/CRC-05089-BRAKLEEN-Brake-Cleaner/dp/B...

That stuff is real good for getting stains out of clothes

Re: Widely used chemical strongly linked to Parkinson’s disease

#314
post #310

Earlier quoted context omitted.

...and as an inhaled surgical anesthetic for children As one who went under inhaled anesthesia a dozen times or more as a child in the 70s, I can only say, "WTF?" It makes a great solvent, so let's put in anesthesia?

> It makes a great solvent, so let's put in anesthesia? Literally, yes. The potency of an inhalation anesthetic is usually directly proportional to its lipid solubility. (Known as the Meyer-Overton correlation.) This is why solvents such as ether and chloroform were used as anesthetics and why N₂O is both an anesthetic and is dissolved in cream to form whipped cream. The mechanism of inhalation anesthetics is not com…

Well, when you put it that way...yeah, with some thought it begins to make a little sense. Because my observational evidence says that solvents in general seem to soak into human skin pretty well, so the same would easily get absorbed by whatever it is that turns the lights out. Thanks for the explanation.

Re: Widely used chemical strongly linked to Parkinson’s disease

#315
post #311

Earlier quoted context omitted.

as an inhaled surgical anesthetic for children and women in labor To be fair though, the restricted audience for the administration of this particular chemical would seem to indicate considerations of safety have been applied, otherwise one would expect a more general pattern. One must suspect there are many more chemicals with similarly hard-to-test-for longterm effects in daily use, note especially the so-called 'f…

I had a couple of operations as a youngster, and from my memory (could be faulty) they would speak to you while you were still on the trolley then waft some gas in front of you as you needed to breathe in. Then, when you were sedated they would get on with the business. I guess they would be able to inject you with something a bit more serious without you squirming, and transfer you to the table etc..

LOL, that's the exact opposite of the majority of my experience in the 70s. In your case, you got the gas, then the shot. I'd get the "pre-op" shot for the mild sedation, then the gas for the main event. "Count backward from ten.", and I'd make it to about seven.

Re: Widely used chemical strongly linked to Parkinson’s disease

#316
Just a reminder that "70% higher risk" is a relative value describing the _fractional_ increase in risk. In absolute terms, the probability of developing Parkinson's (prevalence) was 0.33% in group exposed to TCE and 0.21% in the non-exposed group. So you might also say TCE increases the risk of Parkinson by 0.12 percentage points.

Re: Widely used chemical strongly linked to Parkinson’s disease

#317

Widely used chemical *(that was generally phased out in the 70s) linked to Parkinson's. Still important, but you don't need to start searching product labels in 2023 for it.

I'm not for panicked reporting, but in the face of the stated facts (as far as true) your comment is overly dismissive: the chemical solvent trichloroethylene (TCE)—common in soil and groundwater—increases the risk of developing Parkinson’s disease. The movement disorder afflicts about 1 million Americans, and is likely the fastest growing neurodegenerative disease in the world; its global prevalence has doubled in t…

> including making decaffeinated coffee

Whilst there are many who call decaffeinated coffee a crime against humanity, it is somewhat disconcerting that at one stage, it actually was just that.

Re: Widely used chemical strongly linked to Parkinson’s disease

#318

Just a reminder that "70% higher risk" is a relative value describing the _fractional_ increase in risk. In absolute terms, the probability of developing Parkinson's (prevalence) was 0.33% in group exposed to TCE and 0.21% in the non-exposed group. So you might also say TCE increases the risk of Parkinson by 0.12 percentage points.

Whenever I see articles like this, I think of Piled Higher and Deeper's "Science News Cycle" cartoon.

https://phdcomics.com/comics/archive_print.php?comicid=1174

Re: Widely used chemical strongly linked to Parkinson’s disease

#319
post #297

Earlier quoted context omitted.

I used to wear cotton long pants (thermals) all year, under the suit pant. Not letting the suit pant touch the skin made it easier to wear it for a very long time (multiple months) before dry-cleaning. Don't miss those days of mandatory suit-wear.

It was 98% humidity and 70 degrees at 7:30 this morning. I broke into sweat watering plants with athletic clothes on. It’s now 86 degrees and 65% humidity. Spring has only started. For me it’s not an option. I have to dry clean. It is easier to find alternative materials to cotton for the office but they don’t replace button downs and jeans. They can’t replace a suit, linen is still much too casual.

Well, fingers crossed about the Parkinson's, then!

Re: Widely used chemical strongly linked to Parkinson’s disease

#320
post #226

Earlier quoted context omitted.

Its certainly in the soil and groundwater - but why would it be in the air?

It's no longer uncommon to (carbon) filter drinking water at the tap or in your fridge, which then makes a hot shower likely a major avenue into your body by way of your lungs unless you filter water for the whole house plumbing system.

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