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People with low BMI aren't more active, they are just less hungry, 'run hotter'

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Re: People with low BMI aren't more active, they are just less hungry, 'run hotter'

#311

Post by aantix »

aantix wrote: post #233

Mounjaro (tirzepatide) and Wegovy (semaglutide) are the new class of weight loss drugs. And their results, crush anything before them. Once the price point of these medications come down, you're going to see a massive movement towards these solutions for long term weight loss. It's clear that motivation, accountability, peer pressure simply aren't enough for long term success in keeping weight off. By long term succe…

There's a startup opportunity here.

We saw it with generic Viagra and Hims and Roman.

Calibrate is the early mover in GLP-1 medications coupled with nutritional coaching, but there's a ton of room for competitors.

Re: People with low BMI aren't more active, they are just less hungry, 'run hotter'

#312

Post by LocalPCGuy »

kypro wrote: post #132

Something I think that contributes a lot to how much weight you hold naturally is how insulin sensitive you are. The more insulin sensitive you are the less weight you'll put on and there's a huge range between optimal insulin sensitivity, average, and diabetic. I also suspect (although I'm not an expert) the reason some people find it easier to lose weight while doing OMAD or keto isn't just because they're eating l…

I thought this is a pretty common knowledge for anyone who has actually looked that the reasons why Keto works. Although in general, people also do tend to eat fewer calories on those types of diets also because they reach satiety more quickly with denser/higher fat foods.

But a lot of the doctors that are well known in the keto world (and yes, be very careful and try to verify anything you hear when it comes from someone who has "specialized" in something like keto) is that it has a ton to do with the insulin sensitivity.

Re: People with low BMI aren't more active, they are just less hungry, 'run hotter'

#313

Post by aantix »

aantix wrote: post #311
aantix wrote: post #233

Mounjaro (tirzepatide) and Wegovy (semaglutide) are the new class of weight loss drugs. And their results, crush anything before them. Once the price point of these medications come down, you're going to see a massive movement towards these solutions for long term weight loss. It's clear that motivation, accountability, peer pressure simply aren't enough for long term success in keeping weight off. By long term succe…

There's a startup opportunity here. We saw it with generic Viagra and Hims and Roman. Calibrate is the early mover in GLP-1 medications coupled with nutritional coaching, but there's a ton of room for competitors.

I've personally used Calibrate's platform.

There's zero transparency to the medication approval process.

If you ask a question, you will 1) receive an email 3-5 days later and 2) told that they generally don't provide status updates on medication.

No transparency to the medication approval process, even though obtaining access to a GLP-1 medications for their patients, is a pillar of their business.

Not even a simple "waiting to hear from insurance" on their dashboard.

Super long delays and a snarky support staff to get basic medical questions answered.

Here's their site. https://www.joincalibrate.com/

There's room for competitors.

Re: People with low BMI aren't more active, they are just less hungry, 'run hotter'

#314

Post by matthewdgreen »

nradov wrote: post #308
matthewdgreen wrote: post #305

Earlier quoted context omitted.

We have many unsuccessful treatments that work for a small percentage of patients. That's why we measure treatments by effectiveness rather than identifying existence proofs that it worked for someone.

You're really missing the point. Every patient is unique. That's why competent healthcare providers take a step therapy approach and try cheaper, lower-risk treatments first before moving on to more expensive and riskier medication or bariatric surgery.

You seem to have misread my posts as saying that healthcare providers should immediately move to medication rather than try dietary intervention. I didn't say that, I didn't imply that, I didn't even think it.

What I did say is that we are increasingly learning that overeating is a very complex and life-threatening medical concern that often cannot be solved through dietary intervention. Even people who may die if they don't adhere to a diet frequently have difficulty adhering to one. Saying that there are "existence proofs" that diets sometimes they work is a terrible response.

My view is that we should treat diet as one possible medical treatment, and evaluate it apples-to-apples (in terms of efficacy and side effects) against more recent FDA-approved treatments. And now that we've seen how much impact those treatments can have -- and particularly how critical the GLP-1 mechanism is to the sustainability of weight-loss interventions -- we should work our asses off to find more and better treatments that treat overeating as a health condition rather than a question of mind-over-matter.

You seem extremely attached to your position, to the point where defending your position required you to declare that my relatives "were eating a bunch of other stuff when you weren't looking."

Re: People with low BMI aren't more active, they are just less hungry, 'run hotter'

#315

Post by dilap »

FollowingTheDao wrote: post #303
dilap wrote: post #155

Earlier quoted context omitted.

Absolutely, the mental aspects of hunger are huge, as anyone who has ever had the munchies (super hungry) or taken adderall (super not hungry) can attest. In fact, n6 fats may also promote hunger, via increasing endocannabinoid production. Here's a study I just found in mice: https://pubmed.ncbi.nlm.nih.gov/24081493/ Again just an animal model, but certainly suggestive...

Omega 3 also increases endocannabinoids, but a different form: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685292/ AEA and 2-AG are synthesized from omega-6 polyunsaturated fatty acid (PUFA), arachidonic acid (AA), and are hydrolyzed by fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), Herein, we review the discovery and physiological role of omega-3 eCBs that are derived from DHA and EPA (Figur…

Very interesting! Thanks. From briefly searching, it looks like 2-AG more specifically may be responsible for increased appetite? I am unsure of the effects of n3 derived eCBs...

Re: People with low BMI aren't more active, they are just less hungry, 'run hotter'

#316

Post by convexfunction »

SketchySeaBeast wrote: post #309
convexfunction wrote: post #279

Earlier quoted context omitted.

> That tells me the writing on the wall, and let me be clear about this, the writing is what needs to be written and what people need to read - you're making the decision to NOT have cheesecake when you only kind of feel like it. It's a game of weighing the pros and cons and learning to be satisfied with what you know you should have instead of turning around one day and loving the healthy food more than the unhealth…

Do you weigh everything you eat?

Not quite everything, but outside of rare social eating situations I do weigh my food when I'd otherwise have to make a bad estimate for caloric content (i.e. not single-serving packaged food or food from a restaurant that publishes nutrition facts). I also track my calories, though I'll willfully go over my daily calorie target whenever I feel like it with approximately no guilt.

I'm sure this has contributed to the success of my "diet" -- I also started lifting weights again in this period -- but the comment I was originally replying to was about how weight loss requires discomfort, and the energy density thing has been the key insight for me on how to make it not require discomfort. I see now it reads like I was solely attributing my weight loss to this one weird trick (though I do think it's been the most important factor), so, mea culpa.

Re: People with low BMI aren't more active, they are just less hungry, 'run hotter'

#317

Post by FollowingTheDao »

dilap wrote: post #315
FollowingTheDao wrote: post #303

Earlier quoted context omitted.

Omega 3 also increases endocannabinoids, but a different form: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685292/ AEA and 2-AG are synthesized from omega-6 polyunsaturated fatty acid (PUFA), arachidonic acid (AA), and are hydrolyzed by fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), Herein, we review the discovery and physiological role of omega-3 eCBs that are derived from DHA and EPA (Figur…

Very interesting! Thanks. From briefly searching, it looks like 2-AG more specifically may be responsible for increased appetite? I am unsure of the effects of n3 derived eCBs...

> it looks like 2-AG more specifically may be responsible for increased appetite?

That would be my thinking.

These n3 derived eCBs are pretty new so no one knows. But I can tell you, I have found I get "dry mouth" on occasion when I over do the Omega 3. It used to happen more when I took fish oil capsules which I no longer take.

I am also unable to smoke pot becasue it triggers intense anxiety and panic and I think this is becasue I am more sensitive to the THC. And I think this might be a clue how CBD and THC have different psychological effects. THC = Omega 6 and inflammatory and CBD = Omega 3 and anti-inflammatory in a sense.

https://www.sciencedaily.com/releases/2017/07/170718142909.h...

Re: People with low BMI aren't more active, they are just less hungry, 'run hotter'

#318

Post by SketchySeaBeast »

convexfunction wrote: post #316
SketchySeaBeast wrote: post #309

Earlier quoted context omitted.

Do you weigh everything you eat?

Not quite everything, but outside of rare social eating situations I do weigh my food when I'd otherwise have to make a bad estimate for caloric content (i.e. not single-serving packaged food or food from a restaurant that publishes nutrition facts). I also track my calories, though I'll willfully go over my daily calorie target whenever I feel like it with approximately no guilt. I'm sure this has contributed to the…

Fair enough. I've had excellent success with just calorie tracking / weighing without massively changing my diet - by setting a small caloric deficit I was able to consistently slowly weight over months without massively changing things and enjoying all my usual foods.

I'm glad your system has worked for you.

Re: People with low BMI aren't more active, they are just less hungry, 'run hotter'

#319

Post by polishdude20 »

MichaelCollins wrote: post #220
Aloha wrote: post #196

Earlier quoted context omitted.

The 'it's all my fault' attitude isn't really helpful for you to solve those problems however. Binge eating can be driven by a myriad of factors, mostly psychological. I'm fat too, and I'm comfortable with that word, I dont like medicalizing it with term obesity. While my weight is at least partially my own fault, its at least influenced by factors outside of my control - upbringing, genetics, societal factors, and a…

Whether or not the realization that overeating is my problem helps me solve the problem is orthogonal to whether or not it's true. It is objectively true that I overeat. In my case, I believe I overeat because I have poor impulse control and I enjoy both the act of eating and the sensation of being stuffed with food. Furthermore I particularly enjoy greasy and carby foods, pizza particularly. If I ate less (or stuffe…

Yeah at some point it doesn't matter who's at fault. It matters who will make the change. We tend to think the entity at fault is the entity that needs to remedy the situation. Whoever or whatever you believe is at fault, the person who is responsible for the change is always you. It's easy to blame something and then also mentally picture that thing / or person as the one in charge of fixing the problem.

So maybe the motto is: It's not your fault but it IS your responsibility.

Re: People with low BMI aren't more active, they are just less hungry, 'run hotter'

#320

Post by [deleted] »

amanj41 wrote: post #136
ska wrote: post #118

Earlier quoted context omitted.

> Isn’t this against the laws of physics? No because they were also eating a lot, the lower bound on this established by physics. I've known a lot of roadies who sort-of-correctly believed they could eat as much as they could physically manage, as they were expending enough (3+ hour intense riding daily) that it was a chore to keep up. At least when they were 20-something and racing. Many struggle a bit when the a) g…

The operative word was "couldn't". If they didn't eat as much, they could lose weight

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