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Heart inflammation cases in young men higher than expected after mRNA vaccines

reuters.com

311–320 of 415 posts

Re: Heart inflammation cases in young men higher than expected after mRNA vaccines

#311
post #68

Damn it, I already have heart problems and still in queue for mRNA thinking it was safer than AstraZeneca clots risk. Guess not. Crap.

I am 31 and have high BP and had both shots, first shot was.just arm and side pain. second shot was.just fatigue, but I didn't notice any heart issues. maybe my bp meds help, since they bind to ACE receptors but not sure.

Re: Heart inflammation cases in young men higher than expected after mRNA vaccines

#312
post #202

Earlier quoted context omitted.

> How long do spike proteins (SARS-CoV-2 or vaccine created) hang out if they make it to the heart? As far as I understand it, the vaccine doesn't work like this. It tells your immune system "hey this is what a SARS-CoV-2 spike protein looks like, attack it if you see it". So the vaccine wouldn't cause the heart damage, the vaccine does (intentionally) ramp up your immune system to learn about this new threat, which…

The covid spike protein binds ace2 so the immune response to bind the spike could bind ace2 as well. Normally this is mitigated by a self selection filter but it is not out of the question that you could develop an autoimmune response.

Would it? My naive guess is that the immune response is an anti-ACE2 match. So it would bind to COVID spike protein, not the ACE2 receptor.

Re: Heart inflammation cases in young men higher than expected after mRNA vaccines

#313

Earlier quoted context omitted.

> How long do spike proteins (SARS-CoV-2 or vaccine created) hang out if they make it to the heart? As far as I understand it, the vaccine doesn't work like this. It tells your immune system "hey this is what a SARS-CoV-2 spike protein looks like, attack it if you see it". So the vaccine wouldn't cause the heart damage, the vaccine does (intentionally) ramp up your immune system to learn about this new threat, which…

There are two variants of the vaccine: One is mRNA (?) variant that gets into your cells and makes them produce just the spike protein. This lets your immune system find this protein out and make antibodies. The other contains instead a partially destroyed viruses which trains the immune system directly on all their parts - the shell, the spikes, etc. I don't remember which company makes which kind but both are in pr…

the "partially destroyed" virus is not a covid virus.

example the johnson&johnson vaccine [a vector vaccine] is composed of attenuated [part destroyed] human adenovirus [thus non reproductive] that has an insert of conformationaly stabilized spike sequence. this makes ease of shipping and handling, but lacks good efficacy if you are immune to the adenovirus

Re: Heart inflammation cases in young men higher than expected after mRNA vaccines

#314
post #313

Earlier quoted context omitted.

There are two variants of the vaccine: One is mRNA (?) variant that gets into your cells and makes them produce just the spike protein. This lets your immune system find this protein out and make antibodies. The other contains instead a partially destroyed viruses which trains the immune system directly on all their parts - the shell, the spikes, etc. I don't remember which company makes which kind but both are in pr…

the "partially destroyed" virus is not a covid virus. example the johnson&johnson vaccine [a vector vaccine] is composed of attenuated [part destroyed] human adenovirus [thus non reproductive] that has an insert of conformationaly stabilized spike sequence. this makes ease of shipping and handling, but lacks good efficacy if you are immune to the adenovirus

I think the J&J vaccine uses an adenovirus that can't reproduce in human cells. It's missing something or other it need to reproduce and only grows in a specialized cell culture.

Re: Heart inflammation cases in young men higher than expected after mRNA vaccines

#315

Earlier quoted context omitted.

There are two variants of the vaccine: One is mRNA (?) variant that gets into your cells and makes them produce just the spike protein. This lets your immune system find this protein out and make antibodies. The other contains instead a partially destroyed viruses which trains the immune system directly on all their parts - the shell, the spikes, etc. I don't remember which company makes which kind but both are in pr…

The mRNA vaccines don't produce the entire spike protein, just a portion of it in order to target the antibodies towards that specific portion of the spike.

How much of the spike protein is coded for?

Re: Heart inflammation cases in young men higher than expected after mRNA vaccines

#316
post #313

Earlier quoted context omitted.

the "partially destroyed" virus is not a covid virus. example the johnson&johnson vaccine [a vector vaccine] is composed of attenuated [part destroyed] human adenovirus [thus non reproductive] that has an insert of conformationaly stabilized spike sequence. this makes ease of shipping and handling, but lacks good efficacy if you are immune to the adenovirus

I think the J&J vaccine uses an adenovirus that can't reproduce in human cells. It's missing something or other it need to reproduce and only grows in a specialized cell culture.

yes you have it right.

Re: Heart inflammation cases in young men higher than expected after mRNA vaccines

#317
post #294

Earlier quoted context omitted.

>the OP employing manipulative communication. > ... it's an effort at highlighting the manipulation—with references—so that vulnerable readers are informed and inoculated against it. as i've already shown ( https://news.ycombinator.com/item?id=27467720 ) you invented the "manipulation", ie. you generated misinformation, and you're clearly acknowledging here that you're using that misinformation in order to affect "vu…

> as i already pointed out you invented the "manipulation", ie. you generated misinformation, and you're clearly acknowledge here that you're using that misinformation in order to affect "vulnerable readers", ie. for propaganda purposes. I was clear in providing citations. At this point, you need to provide your own backing for all the other vaccines you've supported, such as the flu vaccine, MMR, etc. if you want to…

>Thing is, even if you're against new-technology vaccines, we have numerous old-technology vaccines following the same paradigms used to make the vaccines I mentioned above (AZ, JJ, etc).

Those two are viral-vector vaccines, which isn't old-technology. They're almost as new as mRNA vaccines.

Re: Heart inflammation cases in young men higher than expected after mRNA vaccines

#318
post #209

Earlier quoted context omitted.

Natural infection won't provide as long lasting of immunity compared to the mRNA vaccines. And if the vaccine is going to inflame your heart, I seriously doubt it's going to be anything but far worse from the natural infection.

Can someone explain why this the mRNA vaccine (which tells your body to produce spike protein and thus mimic the virus) produces long-lasting immunity but the actual virus which is being mimicked does not do that?

I can't answer the mRNA half (because they're brand new and we just don't have that data yet), but I'm pretty sure I know where the "infection does not create long-lasting immunity" side came from:

Around 9-12 months ago, a study came out that said antibodies from infection last 3 months. They couldn't say any longer though because that study only had 3 months of data. Unfortunately, this was largely reported on as "up to 3 months", making a lot of people think immunity only lasted a maximum of 3 months.

Since then, now that we have more data, further studies have come up that keep extending that duration. Last I recall I think there was one that got to "at least 14 months"..? But these ones don't get as much spread as the original wrong reporting, so it got kinda stuck as "don't create long-lasting immunity".

Re: Heart inflammation cases in young men higher than expected after mRNA vaccines

#319

Earlier quoted context omitted.

> How long do spike proteins (SARS-CoV-2 or vaccine created) hang out if they make it to the heart? As far as I understand it, the vaccine doesn't work like this. It tells your immune system "hey this is what a SARS-CoV-2 spike protein looks like, attack it if you see it". So the vaccine wouldn't cause the heart damage, the vaccine does (intentionally) ramp up your immune system to learn about this new threat, which…

There are two variants of the vaccine: One is mRNA (?) variant that gets into your cells and makes them produce just the spike protein. This lets your immune system find this protein out and make antibodies. The other contains instead a partially destroyed viruses which trains the immune system directly on all their parts - the shell, the spikes, etc. I don't remember which company makes which kind but both are in pr…

Chinese vaccine (SinoVac, CoronaVac) uses an inactivated whole SARS-CoV-2 virus.

https://www.medicalnewstoday.com/articles/covid-19-how-do-in...

"... In an inactivated vaccine, the pathogen is killed or modified in such a way that it is unable to replicate. It cannot cause disease and is, therefore, suitable for those with a compromised immune system.

The inactivation step usually involves heat, radiation, or chemicals to destroy the pathogen’s genetic material, which stops it from replicating.

Inactivated vaccines can trigger a strong immune reaction, but it is usually not as strong as the reaction that live attenuated vaccines can produce. Due to this, a person may need booster shots to ensure ongoing protection.

The COVID-19 vaccines that Sinovac, Sinopharm, and Bharat Biotech have developed are inactivated vaccines. ..."

Re: Heart inflammation cases in young men higher than expected after mRNA vaccines

#320

Earlier quoted context omitted.

Not OP but the chance of hospitalization in that age bracket is about 0.2% [0] There appears to be at least a 20% chance that post-vaccine someone of that age will feel rough enough to take medication [1]. People who are currently healthy choosing to avoid the risk of immediate short-term pain when presented with a small, remote gain seems like classic prospect theory! [0] https://www.statista.com/statistics/1122354/…

20% chance of feeling rough enough to take medication does not seem much higher than the human average. Without comparing to placebo it is meaningless.

They did compare it to placebo, plus, humans don’t compare to placebo they compare to their status quo condition.
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