Live data from Hacker News

Current RNA vaccines protect against worrying coronavirus variants

nature.com

311–320 of 324 posts

Re: Current RNA vaccines protect against worrying coronavirus variants

#311

Earlier quoted context omitted.

I can't just walk in. That said I know several people that have had it. Some elderly with existing conditions. Worst case was my aunt who got pneumonia from it. She's in her mid sixties and diabetic. She was in the hospital for a week. Was in the emergency room with my son a few months back, not overflowing or anything, but I wasn't there to track Covid cases.

In Germany they showed the whole shift of an covid nurse on tv. They really should show something similar in every country. Gives you a lot of perspective.

Do you know what the name of this program is? I'd be interested to see if I could find it online somewhere.

Re: Current RNA vaccines protect against worrying coronavirus variants

#312

Earlier quoted context omitted.

In Germany they showed the whole shift of an covid nurse on tv. They really should show something similar in every country. Gives you a lot of perspective.

Do you know what the name of this program is? I'd be interested to see if I could find it online somewhere.

Pflege ist #NichtSelbstverständlich | Joko und Klaas

Edit: It's available on a german video on demand service maybe a vpn will work for you https://www.prosieben.de/tv/joko-klaas-gegen-prosieben/video...

Re: Current RNA vaccines protect against worrying coronavirus variants

#313
post #165

Earlier quoted context omitted.

It is maybe for you but not everywhere, i can see it being referred to as Biontech just as often, if not oftener than Pfizer. Maybe because Germany is our neighboor, but maybe also because it is "more right"

Yeah, I was speaking more to California and the US

"many cities and countries" means California, good to know.

Re: Current RNA vaccines protect against worrying coronavirus variants

#315
post #313

Earlier quoted context omitted.

Yeah, I was speaking more to California and the US

"many cities and countries" means California, good to know.

I've been ruined by your extremely effective oratory skill.

Re: Current RNA vaccines protect against worrying coronavirus variants

#316

Earlier quoted context omitted.

Conversely, we can make the same argument in the opposite direction with the example of Seychelles, which in spite of the highest vaccination level in the world, is still seeing significant growth in cases: https://www.bbc.com/news/world-africa-56992121 Apparently they're using 40% Astra Zeneca, 60% Sinopharm; hopefully the issue is simply the latter being ineffective. But as all the success stories with vaccination…

The AstraZeneca and Sinopharm vaccines have similar efficacy: they're about 80% effective at preventing symptoms. They're even more effective at preventing serious illness and death. The Seychelles is still 40% unvaccinated. Even people who are vaccinated have some chance of getting infected, though if they get infected, their chance of showing symptoms is lower, and their chance of ending up in the hospital is much…

Seychelles has vaccinated 68.5k of its 98.5k population. [Around 25% of its total population](https://en.wikipedia.org/wiki/Demographics_of_Seychelles) are 0-17, so maybe 75k max 18+. Over 90% of adults are vaccinated and less than 7k remain unvaccinated.

Seychelles just reported 1800 cases for the last week or 1.8% of its total population. This equates to 6 million cases in the US or more than 800k per day, a number never approached.

> It looks like the people testing positive in the Seychelles are mostly unvaccinated

It stated that 1/3 were in fully vaccinated and the rest were in partially vaccinated or unvaccinated. There are now 60k that are fully vaccinated, leaving just 8.5k first-dose only. The article was written before the 1800 cases dropped a couple days ago.

More data is needed for hospitalizations and deaths, but as it stands now, it does not look convincing for the vaccine. It's likely more cases will continue to come over the next few weeks, even more than the record breaking prior week.

Seychelles and other island nations that had no major covid outbreaks before vaccine launch (only 500 cases prior and 7.5k since) are the best real life settings we have for vaccine efficacy. For much of the rest of the world, a huge number of people were already infected before vaccine launch, making it difficult to separate out the effectiveness of the vaccine.

Re: Current RNA vaccines protect against worrying coronavirus variants

#317
post #123

Earlier quoted context omitted.

"which from my understanding is a form of gene therapy" You're the one who is asking SOCIAL MEDIA companies (i.e. Facebook and twitter) to educate you more. "I wish the social media giants would just stop all the censorship and allow the discussions to take place." Maybe that's the issue all along. Shouldn't have random people and nefarious state actors provide your education, but maybe go out there and read reputabl…

Nice try, don't try to argue that silencing information is helping because I should educate myself through approved sources rather than conversations with community. Whats next re education camps? Dont be a bully dude!

Anyways, just an update to close out this thread. I made the decision to get my first dose of vaccine and today at 2:44PST I joined team Pfizer.

I am still not 100% convinced but a decision needed to be made and based on the information, a large amount recieved here I chose to get the jab.

Re: Current RNA vaccines protect against worrying coronavirus variants

#318

Earlier quoted context omitted.

Many of us have preexisting immunity. For that population, the marginal benefit of vaccination is zero. People should be informed about the risks.

You can't know what kind of pre-existing immunity, if any, you have against covid.

Including after vaccination? If no, why is that different than infection?

Re: Current RNA vaccines protect against worrying coronavirus variants

#319

Earlier quoted context omitted.

You can't know what kind of pre-existing immunity, if any, you have against covid.

Including after vaccination? If no, why is that different than infection?

No, not including after vaccination. When people speak about pre-existing immunity, it's most of the time covid deniers saying there "natural" immunity and vaccines are useless or harmful.

(Of course there is also valid discussion of pre-existing immunity, but the more nuanced messages are not as common.)

Re: Current RNA vaccines protect against worrying coronavirus variants

#320

Earlier quoted context omitted.

here. do the diff yourself: https://github.com/NAalytics/Assemblies-of-putative-SARS-CoV... I’m not gonna go into how the virus was sequenced or what the process to generate the vaccine was, but in this case, I believe your claim of being 100% identical is wrong.

Please read carefully my previous post. Protein sequence != RNA sequence. I already stated that both coding RNA sequences are different. It is their product, the protein sequence, that is 100% identical in both sequence and structure. The protein that, as you mentioned, is presented as an antigen to the immune system. If you don’t believe me, and since you already found the FASTA mRNA sequence (or, more specifically,…

okay. so the vaccine itself is different, but the end result spike protein is the same. I assumed that the spike proteins would look similar (99.5%+) and was actually expecting differences in the “area that holds the protein together at the base where it would normally bind to the useful virus payload”. i guess i was wrong
Post reply on HN