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Creatine raises brain energy levels and slows cognitive decline: study

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Re: Creatine raises brain energy levels and slows cognitive decline: study

#301

Post by jliptzin »

wtetzner wrote: post #234
jliptzin wrote: post #147

Earlier quoted context omitted.

No but every time I try to take creatine supplements I get heart palpitations. Everyone says I am crazy and that it’s impossible but I have proof from my Apple Watch, one time it was so bad it said I had atrial fibrillation. I went to a cardiologist and he acknowledged it is a possibility but he hasn’t seen it before.

Just out of curiosity, were those creatine supplements pure creatine? Or were they workout supplements that might have also included caffeine or other things?

Pure creatine

Re: Creatine raises brain energy levels and slows cognitive decline: study

#302

Post by j45 »

trehalose wrote: post #176
zug_zug wrote: post #58

Earlier quoted context omitted.

>> Recently, a pilot study (single-arm) by Smith et al., recruited 20 patients (73 years of age) with AD and provided them with 20 grams/day of CrM for 8 weeks [20]. Serum creatine levels were increased at weeks 4 and 8 (p Yeah 20 patients is not a lot. I'm inferring this is a pre-post test. However some of those p-values are pretty good (.001 on reading and and sorting). Very promising pilot study but not conclusive…

I wouldn't even call it "promising but inconclusive" so much as "not conclusively a dead-end for further research". In a single-arm open-label study, with no blinding, both the participants and the researchers know who's getting what. You need a placebo and double-blinding for comparison against the active group and to adjust for any ways in which the researchers may have unwittingly influenced the results. (Or perha…

One study rarely makes or breaks anything. Creatine has lots of studies going back 10-20 years.

Re: Creatine raises brain energy levels and slows cognitive decline: study

#303

Post by 6r17 »

Hatrix wrote: post #288
6r17 wrote: post #284

Earlier quoted context omitted.

right... https://www.google.com/search?q=artificial+creatine+side+eff... kidney damage. liver damage. kidney stones. weight gain. bloating. dehydration. hair loss. muscle cramps. The fact that you estimate weed as a drug is correct - the fact that you don't realize that everything is basically a drug depending on the amount an potency is worrying.

Water is bad for you if you drink too much.

Yes because taking advice to medicine itself everyday based on an online entrepreneur forum to "boot-yourself" is 100% a good advice that you should take blindly without taking a notice on what you are doing.

You are so right.

Re: Creatine raises brain energy levels and slows cognitive decline: study

#305

Post by papascrubs »

firefax wrote: post #220
WhitneyLand wrote: post #36

The article made up the claim it’s not from the paper itself. There was some improvement in cognitive scores, but no placebo group. Without a placebo group, there are a lot of explanations for the data.

Normally I wouldn't ask this, but having seen the effects of Alzheimer's I must ask: is there any evidence that taking creatine will harm my brain? Let's be real: I take a lot of edibles. I smoke sometimes on a hike. Every once in a while I get a Guiness and a gyro. My health is by no means perfect, and if I'm willing to take in literal poison (yes, alchohol is that dangerous that I say such things even about my prec…

Long term studies haven't shown any harm. I've taken 30g a day for well over a year now for both the physical performance and the cognitive benefits. I had brain fog following a bad COVID infection which this has helped with. My family also has a history of Alzheimer's and dementia (both sides), I figure it can't hurt.

The only side effects I've encountered have been mild GI discomfort, and that only rarely (mostly when restarting after a vacation etc-- I drop the routine when I travel). Roughly similar to having a morning coffee at its worst.

I've found I get much thirstier when on this high of a dose. If you're not already a big water drinker I'd definitely invest in a nice insulated bottle to drag around.

Re: Creatine raises brain energy levels and slows cognitive decline: study

#307

Post by pnw »

usef- wrote: post #291
mmanfrin wrote: post #270

Earlier quoted context omitted.

Why would it be? There's no known link at all.

Studies are suggesting cognitive impairment for long-term users: https://www.health.harvard.edu/blog/cognitive-effects-of-lon... ? (That's not technically Alzheimer's, but it's believable someone worrying about one might worry about the other)

I've read that New Zealand study and it's identifying an effect in a small group of heavy users who started using cannabis very young (a full third as teens) and continue to use it heavily (four times a week) three decades later. That's not a huge surprise.

They also state "cognitive functioning among midlife recreational cannabis users was similar to representative cohort norms". It's clearly shown in Figure 1 - midlife recreational cannabis users actually got smarter than people who quit cannabis according to their data.

There may well be some confounding factor in there. The study was done in New Zealand where cannabis was illegal for the majority of participants, and usage was self-reported so there's a basic issue there as well. One of the meta-analysis citing this (Crisafulli, 2026) and finding no effect criticizes the study design.

Re: Creatine raises brain energy levels and slows cognitive decline: study

#308

Post by pnw »

markdown wrote: post #249
kherud wrote: post #189

Feedback about creatine often seems mixed. Many love it, but many also report problems. Just in this thread there are people talking about heart palpitations and sleep problems. I have the theory that these side effects and mixed experiences come from impurities of lesser quality products. Apparently there are mostly two sources: Creatine mono-hydrate which mostly comes from China and "creapure", which is a patented…

> "creapure", which is a patented formula known for its purity You mean known for its branding. Most people have never heard of creapure and those who do haven't tested it for purity.

There are several studies of Creapure and other brands. Most of the studies done on CM use the Creapure brand.

https://pmc.ncbi.nlm.nih.gov/articles/PMC9761713/

https://pubmed.ncbi.nlm.nih.gov/35268011/

Re: Creatine raises brain energy levels and slows cognitive decline: study

#309

Post by mkl »

qnleigh wrote: post #199
WhitneyLand wrote: post #36

The article made up the claim it’s not from the paper itself. There was some improvement in cognitive scores, but no placebo group. Without a placebo group, there are a lot of explanations for the data.

They also quote a follow up study that sounds more compelling: > The 2026 multicenter placebo-controlled trial extending this work enrolled 240 participants with early Alzheimer’s... The intervention group showed slower decline on standard cognitive scales by about 30% versus placebo. But there's no such study in the references section. Not sure what's going on there but I want to see the data before I believe this.

The only other pages I can find talking about this supposed follow-up study seem to be AI slop and similarly fail to include it in their references.

Re: Creatine raises brain energy levels and slows cognitive decline: study

#310

Post by bob778 »

papascrubs wrote: post #305
firefax wrote: post #220

Earlier quoted context omitted.

Normally I wouldn't ask this, but having seen the effects of Alzheimer's I must ask: is there any evidence that taking creatine will harm my brain? Let's be real: I take a lot of edibles. I smoke sometimes on a hike. Every once in a while I get a Guiness and a gyro. My health is by no means perfect, and if I'm willing to take in literal poison (yes, alchohol is that dangerous that I say such things even about my prec…

Long term studies haven't shown any harm. I've taken 30g a day for well over a year now for both the physical performance and the cognitive benefits. I had brain fog following a bad COVID infection which this has helped with. My family also has a history of Alzheimer's and dementia (both sides), I figure it can't hurt. The only side effects I've encountered have been mild GI discomfort, and that only rarely (mostly w…

30g? That seems like a lot - isn’t the standard dose 5g?

Did you build up incrementally and find that to be the best?

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