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Peptides: where to begin?

science.org

301–310 of 431 posts

Re: Peptides: where to begin?

#301
post #273

Earlier quoted context omitted.

But you confuse that set of people with people who don’t know want to inject untested vaccines into their body.

(I don’t) I’m genuinely not aware of a DIY or grey market in vaccines . Peptides, yes, but vaccines ? In the absence of this, I suspect you’re either confused or straw-manning…

I was referring to the MRNA vaccines, which were relatively untested when released to the public. Suspicion of that is very reasonable.

Re: Peptides: where to begin?

#302

Earlier quoted context omitted.

As opposed to this, you have the mindless non-contrarians who unquestioningly believe any assertion by academia or authority, which is a problem too.

I feel like you're completely proving my point here.

Well I have a PhD and have published lots of papers, so I like to think I am educated lol.

Re: Peptides: where to begin?

#303

Earlier quoted context omitted.

looks interesting, but has the classic "40 patients".

What would be enough? 400 patients, 4000, 40k, 400k, 4M?

Well, reading the study, I'm not sure more patients could rescue it from methodological bias. They assumed the premise basically -- we should find a biomarker, which is kind of what this thread is discussing. Then they went trawling for biomarker in a sea of millions of biomarkers. They did this by training an model that produced the desired result, using a grid search for hyper parameters that even further expanded the available degrees of freedom here beyond what they had from the biology. No pre-registration; There are millions of places where the researchers could have made a different decision -- would they still have gotten a publishable result? Oh plus the authors mostly work for the company whose data they use, which is hoping to sell a diagnostic test.

I'm giving you a thorough response because I'm detecting a cavalier anti scientism which I think is sadly becoming more common. This stuff is hard; are you sure you understand it enough to have an informed opinion?

Re: Peptides: where to begin?

#304
post #261

Earlier quoted context omitted.

Why?

Your internal organs can't keep up with that kind of mass fluctuation, for one. Keep an eye on your kidneys.

It seems to be more complicated (or unpredictable?) than that:

> In this study, rapid weight loss was associated with the loss of kidney function in males with normal weight, and with improvement of kidney function in overweight males.

> Our study showed that BMI and BMI change were not associated with eGFR change in females.

https://pmc.ncbi.nlm.nih.gov/articles/PMC4658128/

Re: Peptides: where to begin?

#305
post #293

Earlier quoted context omitted.

The problem is it is so ingrained in US culture that switching to tip-free has generally failed where tried, even in pro-labor lefty hoods in blue cities. Numerous restaurants in NYC tried and flipped back over the last 10 years. Restauranteurs reported illogical / innumerate behavior where sales went down when they switched to untipped higher prices. https://www.eater.com/21398973/restaurant-no-tipping-movemen... Th…

I remember when Uber first came to Austin, one of the big draws was that a tip wasn't expected. The app didn't even allow it IIRC and Uber sort of advertised this as a feature. 15 years later, back to it, tips seem expected again? Oddly enough, the fact that I was initially sold a product where a tip wasn't expected has made me continue to not tip Uber drivers. Not sure what that says about me.

[deleted]

Re: Peptides: where to begin?

#306
post #154

Earlier quoted context omitted.

https://link.springer.com/article/10.1186/s12967-025-07203-w

I think I would need to see testing on a control group of housebound patients with other conditions to believe this. It's easy for ME testing to pick up markers for being housebound and limited exercise for an extended period of time.

You sound exactly like the tens of doctors that misdiagnosed my aunt (who passed away through euthanasia after her symptoms got too bad to live with late last year).

I understand that the symptoms of ME/CFS might be similar to being obese/depressed or housebound, but the problem is that doctors often jump to that conclusion too quickly and don’t take efforts to diagnose ME/CFS leading to situations like my aunt’s. She was also obese and depressed and has been struggling with those symptoms for about 30 years and has constantly been misdiagnosed the entire time because doctors didn’t figure out that those were symptoms of ME/CFS and not two unrelated conditions coming from two different diagnoses.

Thanks to long-covid putting the symptoms of ME/CFS on the forefront lately, there’s finally been some much needed research into the disease and people like my aunt finally get the diagnosis they should have been getting many years ago.

Re: Peptides: where to begin?

#307

Earlier quoted context omitted.

They absolutely do not, unless you’re getting too many calories. Individual foods are—with some exceptions—neither bad for you nor good for you. A healthy diet can occasionally include doughnuts, and milkshakes. Your overall diet is what matters.

Sure. We’re saying roughly the same thing. For most Americans, hamburgers cause heart disease because we don’t exercise enough or eat enough plants. If you’re backpacking twenty miles a day, sure, eat whatever, you won’t suffer inflammation or obesity from it. (Though you may run nutritional deficiencies. And you’re building bad habits for when your activity necessarily tapers off.)

Hamburgers are not causing heart disease and diabetes for most Americans. Bad diets loaded with too many calories, too many saturated fats, and too many simple carbs are.

Messaging matters. When you tell people hamburgers and bacon and everything they love are bad, they stop listening, give up, or just eat some other junk that wasn’t prohibited. When you tell them some foods are good, they start buying into superfood marketing.

Diet is the only thing that matters. Lots of veggies are extremely useful because they add bulk without adding calories, and along with fresh fruits are great sources of fiber. Cheeseburgers can only come so often because they’re extremely calorie dense and send enormous reward signals to your brain.

Give people the tools they need to thrive, not just “don’t eat these specific bad foods, eat these specific good foods”.

Re: Peptides: where to begin?

#308

Earlier quoted context omitted.

If only there were a federal administration whose responsibility it was to collect data about food and drugs so we could rely on something more than anecdotes from random strangers on the Internet.

Do you have a link to those data showing GLP-1 agonists are ineffective?

You didn’t come here with data. You came here with anecdotes and asserted that they were conclusive.

Re: Peptides: where to begin?

#309

Earlier quoted context omitted.

I feel like you're completely proving my point here.

Well I have a PhD and have published lots of papers, so I like to think I am educated lol.

And I should unquestioningly believe you? :P

Re: Peptides: where to begin?

#310
post #268

Earlier quoted context omitted.

I want to point out your own contradictory comments about absorption and specifically mentioning a typically highly processed food (orange juice), one which has been stripped of its natural fibers and flavors. That age group (and all others) should be eating real/whole fruit or having the juice fresh (I.e. just juiced). They would be better served getting this advice than creating more anxiety about protein intake.

Is there any reason to think that freshly squeezed juice is chemically different from, for example, frozen juice concentrate?

From the Wikipedia page on orange juice:

> Commercial orange juice with a long shelf life is made by pasteurizing the juice and removing the oxygen from it. This removes much of the taste, necessitating the later addition of a flavor pack, generally made from orange products.

https://en.wikipedia.org/wiki/Orange_juice

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