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Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out

gavi.org

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Re: Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out

#301

Post by somenameforme »

thaumasiotes wrote: post #296
somenameforme wrote: post #259

Earlier quoted context omitted.

A cure is a treatment, a vaccine is a prophylactic. The most dangerous, by far, cancer that this would help mitigate is cervical cancer which makes up about 0.7% of cancer deaths in the US, exclusively amongst women. The overwhelming majority of cervical cancers occur in Africa due to the fact that HIV/AIDS dramatically increases your susceptibility to developing it.

> The overwhelming majority of cervical cancers occur in Africa due to the fact that HIV/AIDS dramatically increases your susceptibility to developing it. Considering we're talking about a sexually transmitted disease, the much higher prevalence in Africa of having multiple simultaneous sexual partners is surely relevant.

HPV infections can usually be cleared up by a healthy immune system, so there's a causal relationship with the immune system. There's a lot more information on it available here. [1] Risk factors for it managing to progress onto cancer include obviously the type of HPV infection and "immune status, the presence of other sexually transmitted infections, number of births, young age at first pregnancy, hormonal contraceptive use, and smoking."

I also wonder if 'number of births' is not largely a proxy instead for the shift in the immune system of a woman while pregnant; in effect they tend to become slightly immunocompromised, probably as a means of preventing an immune response from harming the baby.

[1] - https://www.who.int/news-room/fact-sheets/detail/cervical-ca...

Re: Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out

#302

Post by mrtesthah »

navi0 wrote: post #283
v3ss0n wrote: post #276

Can I still take that vaccine regardless of sexual activity as a 41 years old male? Will it prevent centers that can cause by HPV?

It could still protect you from one or more strains that you haven’t been exposed to through sexual partners and avoid contracting or passing it along to a future partner. There’s no practical way for a man to be tested for HPV (I asked and the doc said “it’ll be very painful and the result will be the same: get the vax”) I experienced zero side effects when I got HPV vaxxed at 38yo.

There some circumstantial evidence it could help with plantar warts, too.

Re: Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out

#303

Post by fluoridation »

illiac786 wrote: post #257
killjoywashere wrote: post #248

Denmark is in a chronic baby shortage [1] and people in Western democracies are having less sex generally [2]. So, yay, less HPV. Go get vaccinated [3]. Unfortunately, there are some pretty significant (and sad, yes, sad) confounders. [1] https://www.sdu.dk/en/nyheder/faldende-fertilitet [2] https://www.google.com/search?q=western+democracies+decreasi... [3] https://pmc.ncbi.nlm.nih.gov/articles/PMC10399474/

Do you mean there is a causality between less sex and HPV vaccination, when you write “confounder”? I can’t find any study supporting this, hence double checking.

I think maybe they mean that the fact that people are having less sex is confounding the cause-effect relationship between vaccination and fewer cases of HPV. I don't know about people having less sex, though. That seems hard to believe.

Re: Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out

#304

Post by mailund »

tordrt wrote: post #292
xkbarkar wrote: post #290

Earlier quoted context omitted.

In Denmark its not recommended for women over a certain age. So please don’t get it regardless of age. Its not really considered effective for women who have been sexually active for some time. Which is why its only recommended for girls, not women. https://www.ssi.dk/vaccinationer/boernevaccination/vaccinati... . Tldr; Dont rush to get a vaccine that is probably not effective for you. Make an appointment with your d…

There is many different strains of HPV, the likelihood of already have contracted them all is small. It will still protect you against strains you don't have. It also protects against genital warts. The vaccionation program targets young girls because thats the most efficient time to take it and has highest benefit/cost. You will still reap benefits of taking it later. I dont see any reason not to take if you get it…

just keep in mind that not all kinds of HPV vaccines protect against all the strains causing warts! Some do, but not all, check the specific brand you're getting! Obviously cancer is worse, but the extra protection is nice to have.

Re: Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out

#305

Post by actionfromafar »

fluoridation wrote: post #300
whycome wrote: post #266

Earlier quoted context omitted.

Maybe. The fact that some animals are especially immune to cancers suggest there are ways to prevent the outcome (cell replication/mutation).

Are they immune to cancer, or do they simply not live long enough to develop them? AFAIK, only plants are immune to cancer.

Elephants and naked mole rats.

https://www.sciencealert.com/these-animals-can-t-get-cancer-...

Re: Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out

#306

Post by DaSHacka »

buellerbueller wrote: post #39
DaSHacka wrote: post #28

Earlier quoted context omitted.

[flagged]

>I'd rather take my chances with the actual disease at this point.. Gross, @DaSHacka. Absolutely vile.

Not as vile as having sex with someone who's already infected, whether protected/vaccinated or not.

Re: Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out

#307

Post by throw738488 »

mailund wrote: post #304
tordrt wrote: post #292

Earlier quoted context omitted.

There is many different strains of HPV, the likelihood of already have contracted them all is small. It will still protect you against strains you don't have. It also protects against genital warts. The vaccionation program targets young girls because thats the most efficient time to take it and has highest benefit/cost. You will still reap benefits of taking it later. I dont see any reason not to take if you get it…

just keep in mind that not all kinds of HPV vaccines protect against all the strains causing warts! Some do, but not all, check the specific brand you're getting! Obviously cancer is worse, but the extra protection is nice to have.

[flagged]

Re: Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out

#308

Post by stared »

There is recent research showing that it can (slightly) help even during HPV infection, see "Effect of HPV Vaccination on Virus Disappearance in Cervical Samples of a Cohort of HPV-Positive Polish Patients", J Clin Med (2023) https://pubmed.ncbi.nlm.nih.gov/38137661/.

Also, the eligibility criterion of not vaccinating people above certain age is NOT valid. I mean, sooner better. But if you are adult and there is any chance that you ever get a new sexual parter, get a vaccine.

90% people with get at least one HPV strain in their life. 10-30% people have at least one HPV strain right now.

(I recommend doing PCR test with strains genotyping. I do it periodically.)

Sure, our organism usually gets rid of such on 1-3 years, with no consequences. Yet, vaccine boosts your immunity.

Also, over 50% of cases of throat cancer are HPV-lead. So if you have male body, also vaccinate - both to protect others and yourself. Ideally for 9 strains, but HPV 16 and HPV 18 are by far the most important.

A few more links: https://pinboard.in/u:pmigdal/t:hpv

Re: Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out

#309

Post by illiac786 »

fluoridation wrote: post #303
illiac786 wrote: post #257

Earlier quoted context omitted.

Do you mean there is a causality between less sex and HPV vaccination, when you write “confounder”? I can’t find any study supporting this, hence double checking.

I think maybe they mean that the fact that people are having less sex is confounding the cause-effect relationship between vaccination and fewer cases of HPV. I don't know about people having less sex, though. That seems hard to believe.

Ah, got it. That is a valid point.

Re: Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out

#310

Post by robocat »

pixelpoet wrote: post #262
user432678 wrote: post #211

Earlier quoted context omitted.

Finally, affordable housing!

Yeah, screw those old people with their houses! We should deliberately kill them off so that we can have cheaper houses! But please, don't let the next generation do that to us when housing turns out to be expensive for them too! Brilliant.

I have yet to see my government subsidise dangerous recreations based on a cost benefit analysis.

I think government costs for a retiree are about NZD27000 a year.

A government should be subsidising a good deadly recreation for say NZD10000 a year. Assume expected life remaining is 10 years, assume recreation has a 10% chance of clean death, assume low chance of expensive ongoing chronic outcomes.

Suggestions: Car racing, climbing, fentanyl habit, boat racing, ocean sports, Russian roulette, foreign legion soldiering, free climbing, wingsuiting.

Maybe a better way would be to allow people to gamble with their lives to win a few tens of thousands (need to balance costs against expected savings). Pay out to winners, but saves the government their expected lifetime of expenses for the losers. Let the old and unhappy roll-the-dice and the winners get to live it up a little . . .

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