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Ozempic shows anti-aging effects in trial

trial.medpath.com

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Re: Ozempic shows anti-aging effects in trial

#301

Post by Izkata »

Der_Einzige wrote: post #247
Aurornis wrote: post #222

Earlier quoted context omitted.

> It's not confirmation bias when it's more then 1 in every 3 people If you construct your argument to exclude the 2 out of 3 people who are not overweight and then point out that the remaining 1/3 is overweight, that's the definition of confirmation bias. It's also a disingenuous argument because not all of those 40% are actively trying and failing to modulate their weight in any way. Most people just don't care.

No way that it’s only 40%. Well over half are overweight. Any definition claiming only 40% is lumping in a lot of fatties with the “not overweight”.

They got the right number with the wrong descriptor. It's about 40% obese (and 78% overweight, last I remember).

Re: Ozempic shows anti-aging effects in trial

#302

Post by _345 »

sarchertech wrote: post #266
ranger_danger wrote: post #240

Earlier quoted context omitted.

[flagged]

Doctors don’t get paid for writing prescriptions. They don’t get kickbacks for writing prescriptions. A small subset of doctors are paid by pharmaceutical companies to run trials or provide expertise, but you can look that up since it’s publicly available information, and it’s not based on them prescribing you anything. At most a drug rep comes by and brings donuts or something to talk about their new drugs. Source w…

My dad got box seats to a hockey game when I was a wee lad so theyll sometimes throw money at docs

Re: Ozempic shows anti-aging effects in trial

#303

Post by ses1984 »

sarchertech wrote: post #270
throwawaylaptop wrote: post #199

Earlier quoted context omitted.

Billions of people were not overweight when they ate those things. They did not eat them 3+ times a day. I said in my other posts.. if someone needs help maintaining or gaining weight, eat those things. If you are overweight, you should be eating ZERO of them. "Basically killing them" means whatever the current obesity and type 2 diabetes epidemic means.

You don’t think people ate carbs 3 times a day in the past? The majority of humans for the majority of recorded history have eaten some kind of bread, rice, potatoes, porridge, or corn with the majority of their meals.

Also in the majority of recorded history being fat was a sign of wealth. I don't think the majority of humans had a surplus of carbs available to overeat them. It's not that carby foods are inherently bad, there's just something bad about the way they fit into modern society, for some people.

Re: Ozempic shows anti-aging effects in trial

#304

Post by drcode »

p1dda wrote: post #290

Please stop with these obvious pharma ads, nobody needs to take Ozempic! Change your lifestyle and most importantly: STOP EATING JUNK FOOD

But junk food is fun: Maybe we can eat junk food, have fun in life, and still be reasonably healthy, with the help of science

(and if glps don't work well enough to allow this, then maybe the next medicine in the pipeline)

Re: Ozempic shows anti-aging effects in trial

#305

Post by radicaldreamer »

anitil wrote: post #299
some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

I see a similar hesitancy around anti-alcohol addition treatments like naltrexone. People almost _want_ it to be difficult to quit (or lose weight), like there should be some moral struggle associated with it

Its the same root cause: they think alcoholism or alcohol dependency is a moral failing so there should be struggle and punishment to overcome it.

Re: Ozempic shows anti-aging effects in trial

#306

Post by mbac32768 »

jjice wrote: post #54
some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

I was kind of scared of these when Ozempic starting picking of steam for weight loss. I was worried that this would be having more negative effects. Turns out, generally speaking, if used with you doctor, these things are pretty safe, especially comparatively to some of the negatives of being overweight. And then I saw some of the stories on HN about how it's changed peoples lives for the better. And then people in m…

The skepticism people have towards metabolic dysregulation models of obesity is too much.

We know for a fact the inverse happens: girl starves herself for years to slim down to become a ballerina, eventually decides it's not worth it and tries to stop being so dangerously thin and... can't. She never feels hungry. Every time she eats she can only stomach a few bites before pushing it away. Just eat ice cream? Instant puke. She cannot gain weight no matter what.

Obviously she broke her metabolic system and she obviously did it through diet.

Yes it's possible for some skinny people to gain weight. But that doesn't mean every skinny person simply can decide to be fat just by eating. It's like climbing Mount Everest for some skinny people to put weight on, even if they really desperately want to.

I don't think the situation with obese people is all that different.

Re: Ozempic shows anti-aging effects in trial

#307

Post by SchemaLoad »

jfim wrote: post #75
drowsspa wrote: post #59

Earlier quoted context omitted.

People are mostly sympathetic when it's physical issues. Psychological issues are treated as diseases of the soul that you only need God or willpower or whatever to fix. And most fat people are fat because of the incentives in our society, but admitting that also goes against certain political ideologies...

What are the incentives for people to be fat, out of curiosity? Do you mean farm subsidies for corn, for example?

It's not that there are incentives for you to be fat, but there are incentives for things which happen to cause you to be fat.

The car industry is a huge one. Making people drive everywhere means more car sales, more fuel sales, more infrastructure built for more cars. And it also makes you fat as a side effect.

Re: Ozempic shows anti-aging effects in trial

#308

Post by SchemaLoad »

throwawaylaptop wrote: post #146
noah_buddy wrote: post #20

Earlier quoted context omitted.

Many people (will only speak to America), view being fat as a literal moral failing. Gluttony or overeating are not the sin, but being fat. (From that perspective:)a miracle cure that allows someone to stop being fat is like an indulgence (in the Roman Catholic sense). It’s a cheat, a shortcut that allows the unworthy to reach a state they do not deserve. My opinion is to wait long enough to validate there are no lon…

You can be gluttonous and still thin. I eat 2 lbs of ground beef a day, with tons of cheese on it. For breakfast I have 6-8 eggs, with cheese. I have my morning coffee with heavy whipping cream. For desert, I whip up some of the heaving whipping cream and have it with frozen berries thawed out. It drives gfs nuts but they're too anti fat to try it.

That still pales in comparison to what a lot of obese people are consuming. Some ground beef is nothing compared to chugging a 2L coke a day.

Re: Ozempic shows anti-aging effects in trial

#309

Post by ses1984 »

slavik81 wrote: post #288
nosignono wrote: post #178

Earlier quoted context omitted.

Adderall produces a very, very different experience and is prescribed to address a very, very different root cause.

However, amphetamines such as Adderall were also sometimes prescribed for weight loss. I'm surprised it was done so rarely before Ozempic was a thing. They were quite effective.

The side effects of adderall are pretty bad. If I'm on a dose that's high enough to suppress my appetite, then I get a very bad crash in the evening. I start to feel like if I want to enjoy life after work, I need to take another adderall to feel normal. That disrupts sleep, and then things start to get really bad.

Re: Ozempic shows anti-aging effects in trial

#310

Post by cthalupa »

nradov wrote: post #255
42772827 wrote: post #241

Earlier quoted context omitted.

The choice is no longer between "cutting out bread and sugar completely" and "some kind of lifelong moderation for a person that has struggled." The choice is now between "cutting out bread and sugar completely" and "removing the struggle to moderate bread and sugar." You're clearly an advocate for your father making healthy choices. So why would you advocate against the use of a drug that makes that easier?

Why waste money and risk side effects for a drug that's not actually needed? Changing your habits is much easier.

This is such an absurd statement.

If changing your habits was much easier then we wouldn't need these medications and the world wouldn't keep getting fatter. People have known how to not be fat for a long time, yet the obesity rate has been rising worldwide, even in countries that have traditionally been skinny.

It's not like fat people on the whole are ignorant of how to become not-fat and never attempt to do so.

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