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GLP-1 drugs: An economic disruptor? (2024)

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301–310 of 553 posts

Re: GLP-1 drugs: An economic disruptor? (2024)

#301
post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

Any negative side effects?

Re: GLP-1 drugs: An economic disruptor? (2024)

#302
post #10

Earlier quoted context omitted.

As opposed to the good long term effects of being obese?

I personally can't believe humanity is in such a state of decay that the two options allowed to be discussed are "50% of the population is morbidly obese, has 0 impulse control and will literally eat themselves to the grave" and "ozempic for life for 50% of the population" Are we just a bunch of NPCs waiting for the orders? One day it's McDonald's selling you the disease the next it's Novo Nordisk selling you the cur…

I'm not sure what you mean by "allowed". It's common and quite popular to discuss other strategies for controlling obesity. If someone invented a diet or exercise plan that works as well as Ozempic, it would be huge. But nobody's yet been able to do so, which I suspect is because diet and exercise are fundamentally not effective anti-obesity strategies.

Re: GLP-1 drugs: An economic disruptor? (2024)

#303
post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

> being overweight will be a choice Not everyone can take these drugs. Some people will have severe side effects. It's very common to have nausea, vomiting, etc., and some people will experience these frequently enough that the prescribing doctor will rescind the prescription.

Those side effects are from injecting weekly doses, right?

I'm curious if daily oral doses which are smaller will solve a bunch of these problems at once, while also mitigating the supply-chain problems.

Re: GLP-1 drugs: An economic disruptor? (2024)

#304

Earlier quoted context omitted.

> being overweight will be a choice Not everyone can take these drugs. Some people will have severe side effects. It's very common to have nausea, vomiting, etc., and some people will experience these frequently enough that the prescribing doctor will rescind the prescription.

I tried, I got some results but it meant that my entire body’s digestive system felt like it stopped working. Constipation, nausea at the drop of a hat, finding I’d have to take a fast acting prescription anti nausea multiple times a day. I’m not that overweight, and I felt like my body was getting far less healthy and like I was starving myself. This is on the lowest starter dose, too! It just… yeah, it works as I’d…

Are these the same effects that folks would get if they stopped eating cold turkey?

Would Zofran throughout the day help with the side effects until the body adjusted?

Re: GLP-1 drugs: An economic disruptor? (2024)

#305
post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

> The most important aspect of the drug that makes it work so well is it forces you to change your habits, no will power required. It also punishes you for bad eating habits. (That late night trip to McDonalds will have you feeling like shit the next day).

But the late night trip to McD's always makes you feel like shit the next day, it's just that we then forget and do it again. (Same with drinking).

Re: GLP-1 drugs: An economic disruptor? (2024)

#306

Earlier quoted context omitted.

> Yes well your PCP / pharmacist should not have prescribed you an appetite suppressant when you have below average body fat %. Why do you think this? I agree that people who have associated risk factors should be prioritized, but if there's enough for everyone why wouldn't we give it to anyone who wants it?

People who don't need to be chronically medicated should not be. There are always side effects, and we don't even know for sure what the long term risks of these medications are yet. And crowing about saving $200/mo not buying food at Starbucks, well now Novo Nordisk is getting that. Toast a bagel at home for $0.50/day instead.

what kind of crap bagels are you buying for 50 cents?

Re: GLP-1 drugs: An economic disruptor? (2024)

#307
post #61

Earlier quoted context omitted.

Luckily during the “shortage” you can currently get GLP-1’s in vials rather than injection pens. The brand name GLP’s you can’t control the dose. But when you get it in a vial from a compounding pharmacy you can inject however much or little you want. Not looking forward to ever using the brand name version specifically for this reason

Aren’t any states like California trying to ban compounding pharmacies? It’s an unfortunate attack on individual freedom, but I am not sure if we will still have them 20 years from now.

I think the issue is more the FDA has hit compounding by announcing semaglutide and tirzepatide are no longer in shortage - so compounding pharmacies aren't legally able to sell the cheaper compounded versions. Since most insurances don't cover GLP-1 for weight loss, this is a huge issue given they cost almost $2000/month in the US out of pocket.

I was approved for semaglutide but now compounding pharmacies like Hims are stating their cheaper (<$200/month) compounded versions are out of stock.

Re: GLP-1 drugs: An economic disruptor? (2024)

#308
post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

[deleted]

Re: GLP-1 drugs: An economic disruptor? (2024)

#309
post #10

Earlier quoted context omitted.

As opposed to the good long term effects of being obese?

I personally can't believe humanity is in such a state of decay that the two options allowed to be discussed are "50% of the population is morbidly obese, has 0 impulse control and will literally eat themselves to the grave" and "ozempic for life for 50% of the population" Are we just a bunch of NPCs waiting for the orders? One day it's McDonald's selling you the disease the next it's Novo Nordisk selling you the cur…

[flagged]

Re: GLP-1 drugs: An economic disruptor? (2024)

#310
post #243

Earlier quoted context omitted.

"Gastrointestinal side effects" I assume that is code for excessive and frequent evacuation of watery feces.

It’s actually the opposite. GLP-1s slow down the digestive tract, so my shits are far more well formed than before. This isn’t like olestra, where excess fat caused diarrhea.

Ok I'd been considering it already, but now I'm sold. I have the transit time of a canid.
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