301–310 of 320 posts
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Agree with all except wondering what you mean by the safety profile being not great? It's been around for 70 years, taken by millions over very long periods of time with relatively minimal negative side effects.
Do you have sources for that? Would like to know the numbers.
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> Supply is not an issue Well, I was going to order some, been researching for a couple days before buying, and in that time all stock on my known pharmacy sites is now gone.
How does one find these sites? I've never been able to determine which are reputable
Since this 13th of February, the Koreans recommend the use of hydrochloroquine for patients infected by the covid-19 [1]. The Covid-19 fatality ratio in Korea is one of the lowest in the world, around 1%. The study in France showing a spectacular drop in covid-19 viral load after only 6 days of hydrochloroquine treatment has been directed by Pr Didier Raoult who is the most cited researcher on infectious disease in t…
In France, when Pr Didier Raoult in 25th of February [0] said that the chinese found that chloroquine was effective like it is effective against SARS-CoV (2003) [1], it was considered a fake news by "Le Monde" one of the most read journal in France...
Only now, because he has published a study [2], people are starting to say: "may be we need to check further"...
Everybody was saying: "Yeah, but there is side effect". Their team has used this drug for decade and know exactly how it works and how to use it...
So people, please, please, let's the real expert do the talking.
[0] https://www.mediterranee-infection.com/coronavirus-vers-une-... [1] https://virologyj.biomedcentral.com/articles/10.1186/1743-42... [2] https://www.mediterranee-infection.com/hydroxychloroquine-an...
Since this 13th of February, the Koreans recommend the use of hydrochloroquine for patients infected by the covid-19 [1]. The Covid-19 fatality ratio in Korea is one of the lowest in the world, around 1%. The study in France showing a spectacular drop in covid-19 viral load after only 6 days of hydrochloroquine treatment has been directed by Pr Didier Raoult who is the most cited researcher on infectious disease in t…
I'm reminded of the old armour-where-the-bullets-aren't story [0]. The most important things to watch out for are places where symptoms don't show up at all. One interesting challenge that the people doing studies must be facing is that by the time symptoms get bad the virus is probably to some degree irrelevant. If someone's lungs have given out then whether or not there are virus particles in their body probably do…
https://www.reddit.com/r/medicine/comments/fkb0wa/university...
We definitely want more studies, but IMO we're reaching a tipping point. We have anecdotal evidence from China and South Korea, and this quite flawed, but at least data-containing study from France. Chloroquine's safety profile isn't great, but the safety profile of COVID is way worse. If you look at Chemotherapy for example, one would never take any of those drugs unless you had cancer. COVID isn't quite as bad as c…
> Chloroquine's safety profile isn't great, but the safety profile of COVID is way worse. If you look at Chemotherapy for example, one would never take any of those drugs unless you had cancer. The FDA's Office of new drugs is split into divisions (dermatology, oncology etc) and the different divisions have different approval criteria as you mention. From my Onco friends' PoV, cancer patients are pretty much assumed…
"Hydroxychloroquine has not been associated with significant serum enzyme elevations during therapy of rheumatologic diseases. Furthermore, clinically apparent liver injury from hydroxychloroquine is rare. " https://www.ncbi.nlm.nih.gov/books/NBK548738/
"Despite use for more than 50 years, chloroquine has rarely been linked to serum aminotransferase elevations or to clinically apparent acute liver injury."https://www.ncbi.nlm.nih.gov/books/NBK548224/
It seems to me that we should immediately move to massively increase production of hydroxychloroquine. If it turns out to be part of a solution, great. If not, I doubt that more than a tiny fraction of the total resources dedicated to the pandemic would have been used up by the effort. There is no time to take things slowly in our situation. In any case, from what I've read on places like r/medicine, many people who…
Supply is not an issue: https://www.fiercepharma.com/pharma/new-commitments-mylan-an... We need testing that the medical community will accept.
Potential Coronavirus Treatment Touted by Trump Already in Shortage, Pharmacists Say
https://www.nytimes.com/reuters/2020/03/19/world/asia/19reut...
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> I would say the same thing regardless of the man on the podium. Must have been hard for you to stomach 2009 then when 60 million Americans got infected with H1N1, nothing whatsoever was done, and the CDC budget was cut the very next year.
We didn't have to stomach much. https://www.propublica.org/article/no-president-trump-the-co...
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Supply is not an issue: https://www.fiercepharma.com/pharma/new-commitments-mylan-an... We need testing that the medical community will accept.
> Supply is not an issue Well, I was going to order some, been researching for a couple days before buying, and in that time all stock on my known pharmacy sites is now gone.
It should not be used as a prophylactic at this time.
Its use should be prescribed and monitored by a doctor.
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Supply is not an issue: https://www.fiercepharma.com/pharma/new-commitments-mylan-an... We need testing that the medical community will accept.
That's false. Potential Coronavirus Treatment Touted by Trump Already in Shortage, Pharmacists Say https://www.nytimes.com/reuters/2020/03/19/world/asia/19reut...
The article I cited suggests 200 million doses are on their way.
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That's false. Potential Coronavirus Treatment Touted by Trump Already in Shortage, Pharmacists Say https://www.nytimes.com/reuters/2020/03/19/world/asia/19reut...
Even if true (I don't really believe it), very temporary. The article I cited suggests 200 million doses are on their way.
That's strange.
It's perhaps worth noting that the two main points made in the two separate articles - that roughly 200 million doses will be available at some indeterminate future date including 130 million from Novartis if hydroxychloroquine is approved for treatment of COVID 19, and that the currently unfounded hype surrounding hydroxychloroquine has caused an immediate problem for some currently prescribed patients and four out of eight licensed manufacturers are in shortage - are not at all contradictory. I would not want to be one of the patients currently dependent on that drug right now.
I do appreciate your pointing out to another poster that they shouldn't acquire it without a prescription and a real need. I would think what was said might be a clue to you that the shortage the NY Times was talking about is more than plausible. People are not (forgive me for stating the obvious) fully rational or thoughtful of their fellow man when making their purchases lately.