This is amazing! It's pretty surprising to me how little there is on the board. It looks comprehensible. I wonder if you could do this with a modern CPU and RAM. What would it look like?
userbinator's comments are good, and to extend his remarks obviously the solution to clock skew is to simply lower the clock rate. Good luck using a solderless breadboard at 500 MHz digital LOL. But breadboards work just fine at single digit MHz rates. There is a problem. Many processors use dynamic registers and require a clock above a certain rate to refresh the registers. Yes, no kidding, dynamic ram cells as CPU…
Schmartboard also makes 1.0mm pitch BGA adapter boards, but a lot of the high-end stuff these days is moving to 0.8/0.5/0.4mm pitch. Of course, for those kinds of things, the extra parasitics of an adapter board are probably a no-no in any case.