Live data from Hacker News

Studies: Blood from young mice reverses aging in old mice

nytimes.com

31–40 of 54 posts

Re: Studies: Blood from young mice reverses aging in old mice

#31
post #26

It's long been known that replacing the blood of an elderly person with that of a youth will make the codger feel like a million bucks. It really does work and, if I were a wealthy old guy, I would definitely have a stable of donors on hand and get weekly treatments.

Do you have any links for this effect?

Re: Studies: Blood from young mice reverses aging in old mice

#33
post #27
post #24

Earlier quoted context omitted.

Please don't post substanceless one-liners here. i.e. don't make jokes. I've wondered about this because I've done the same thing and gotten downvoted. There's nothing about not making jokes in the guidelines. Personally I like a little humor mixed with my HN. Is there some unspoken guideline that HN is supposed to be humorless? And on a semi-serious note, isn't mildly interesting that one of the most common cultural…

scott_s made an insightful comment about this recently: https://news.ycombinator.com/item?id=7609289 . HN isn't against humor per se. Personally, when I read Reddit, I'm in awe of how good the best jokes are. The problem is that you can't have everything; with a culture of humor comes a flood of lame humor. HN's tradeoff is to optimize for signal-noise ratio, so that stuff tends to get hammered. There are other place…

Sometimes a really clever one-can contain an amazing amount of information (laconic humour is a good example of this[0]). The signal-to-noise ratio can be very high here.

[0] http://en.wikipedia.org/wiki/Laconic_phrase

Re: Studies: Blood from young mice reverses aging in old mice

#35
post #22

It's been known for centuries that drinking blood of young... Oh wait, that was a movie :)

There is a Brazilian book for teens that has the story of a group of criminals kidnapping children between 12-14 in order to harvest their blood. Of course, it's more a satirical and comedic book, with the usual gang of boys and girls solving the problem.

Re: Studies: Blood from young mice reverses aging in old mice

#36
post #24
post #3

Earlier quoted context omitted.

Please don't post substanceless one-liners here. The second one sounds more serious, but "wow time to start talking about the ethics of immortality" doesn't engage with anything in this article; it's simply an immediate leap to something generic and obvious. That is not what HN discussions need.

Please don't post substanceless one-liners here. i.e. don't make jokes. I've wondered about this because I've done the same thing and gotten downvoted. There's nothing about not making jokes in the guidelines. Personally I like a little humor mixed with my HN. Is there some unspoken guideline that HN is supposed to be humorless? And on a semi-serious note, isn't mildly interesting that one of the most common cultural…

Would it be that bad if one of the best places for intelligent tech discussion online didn't include humour? There's an abundance of humour everywhere else.

Re: Studies: Blood from young mice reverses aging in old mice

#37
post #25

Earlier quoted context omitted.

Aging is more than just accumulated dammage, menopause is a clear counter example to this idea. However, dammage does accumulate so like most complex systems there are no simple answers.

Isn't menopoause caused by running out of eggs? Actually this is the same mechanism as reported in this story - a lack of stem cells. The interesting thing about this is the stem cells can be reactivated.

That's an oversimplification - menopause results from decreased levels of hormones that would normally be secreted during the process of egg maturation, among other potential causes [see ref 1].

Further, all the eggs a woman will ever have are created while she is developing in her own mother. This is totally distinct from stem cells, many of which are able to generate new stem cells throughout our lives, albeit at an ever-decreasing rate.

[1] http://www.mayoclinic.org/diseases-conditions/menopause/basi...

Re: Studies: Blood from young mice reverses aging in old mice

#38
post #13

Earlier quoted context omitted.

Scientists do a lot of grotesque things to mice, rats and insects all the time. We have to test stuff on someone, and humans are not really acceptable, even with consent.

I agree with you.. but.. going to argue the other way anyway ;) Isn't a consenting subject better than a forced subject? The mice had no say, but a human does..

Choice is an interesting question for the ethicists, but there are also many more reasons to use mice, rats, fruit flies and other animals: you can easily get thousands of genetically similar ones, you can get ones bred with specific properties, they have shorter life cycles, so you can test what happens during life time, you can test to destruction/death, you can test before consent be given, you can test multiple generations, you can keep them in controlled conditions. All of those are things that are either impossible to get consent for or prohibitively time consuming or expensive with humans.

There are other reasons why test animals are not that useful, mostly because they aren't human, and what works in them might not work on people, and what doesn't work in them won't be tested on people.

Over time animal testing has been decreasing and will continue to decrease while cell cultures become easier to create and closer to the cell structures that need to be tested, but for now they are needed in many fields of science.

Re: Studies: Blood from young mice reverses aging in old mice

#39
post #25

Earlier quoted context omitted.

Aging is more than just accumulated dammage, menopause is a clear counter example to this idea. However, dammage does accumulate so like most complex systems there are no simple answers.

Menopause is not a clear counter example. For all intents and purposes it is a symptom of biological aging and thus the result of "accumulated damage" (assuming that is indeed the overarching mechanism).

Menopause usually starts around 51 but there is a lot of variability and around 1 percent of women experience menopause before age 40. So it's not a direct result of cell damage. Now, if your suggesting that it's an evolutionary response to cell damage that's possible however as fixing the damage would not remove that response the difference is somewhat meaningless.

Changes in brain chemistry are another thing that's probably not directly damage related as the declines start around mid 20's.

PS: Biology has a lot of odd edge cases, youngest mother is 5 oldest 74. http://en.wikipedia.org/wiki/List_of_youngest_birth_mothers

http://en.wikipedia.org/wiki/Pregnancy_over_age_50

Re: Studies: Blood from young mice reverses aging in old mice

#40
post #14
post #10

Earlier quoted context omitted.

Should be done outside the normal blood donor system. There's not that much donor blood around, so it would be unethical to use it. Not a practical problem, but it would look and feel bad. Anyway, yes, why not try this on humans? Sounds perfectly reasonable.

Because of cancer. As mentioned in the article: "Waking up stem cells might lead to their multiplying uncontrollably."

Scientists discover some weird thing they didn't expect, and start spitballing about what the pros/cons could be when reporters show up. News at 11.
Post reply on HN