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Sleep research led to a new sleep apnea drug

temertymedicine.utoronto.ca

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Re: Sleep research led to a new sleep apnea drug

#31

Post by LooseMarmoset »

folkrav wrote: post #24
Waterluvian wrote: post #17

Earlier quoted context omitted.

My AHI was 151 when measured. The CPAP has changed my life but I do look forward to any possible way to not need it anymore.

Oof, and here I thought my AHI of 69 was bad (which it kind of is regardless). My condolences. Glad the CPAP helped, it completely and utterly changed my life too.

256 here :(

the cpap is a wonder, I can't sleep without it. I only wish I'd gotten one 10 years sooner. I have whole years of my life missing from my memory - REM sleep is very important to long-term memory formation.

Using my CPAP now nets me about 1.5 AHI.

if your doctor tells you to get one, get one.

Re: Sleep research led to a new sleep apnea drug

#32

Post by Bender »

I was never diagnosed with sleep apnea but I had an O2 saturation alert when I would sleep side sleeper so I bought a cervical pillow and found a quiet CPAP machine. I add saline and a few drops of very diluted I+KI to the water just to keep anything from growing in it despite changing it daily. I love it. My sleep has never been better. I often forget I have the little nose mask thing. The cervical pillow is awesome, never goes flat. My biggest improvements were from that little cervical pillow.

Re: Sleep research led to a new sleep apnea drug

#33

Post by adamtulinius »

wincy wrote: post #26
adamtulinius wrote: post #21

I wake up without my cpap mask after a few hours every night. In total I might get 6 hours with it after putting it on multiple times. Doctors think I’m doing fine due to total amount of hours used, and my resmed cpap claims I’m at below 1 event/hour. I’m not doing fine and I think the numbers are lying to me. I snore a million, my mouth gets dry, and my nose tightens up, so my nasal mask isn’t always that nice to us…

Obviously I don’t know you or your specific situation, but I lost 120 pounds taking Zepbound and my apnea is gone. I make sure to take fluticasone in each nostril before I sleep, but getting to a healthy weight eliminated my apnea. If you aren’t overweight, this might not help, but hopefully it’ll help someone!

I’m 130 kg and know it’s way too much. Hard to gather the energy for loosing weight.

Can you take fluticasone permanently? Sometimes it’s like I just lie down and my nasal congestion gets worse instantly

Re: Sleep research led to a new sleep apnea drug

#34

Post by cortesoft »

crazydoggers wrote: post #15
rattlesnakedave wrote: post #7

Great. Something like 60% of OSA cases are linked to obesity. GLP-1 drugs could probably lead to resolution for a lot of them if the Lilly SURMOUNT-OSA trial tells us anything.

Although there is a link in many cases, there are a lot of cases where there’s no obesity link at all. The preconception that it is mostly obesity related is a dangerous stigma since it prevents a lot of people understanding what is happening and getting treatment. I started with sleep apnea in my 20s when I was in amazing physical condition. I would jolt awake, heart racing, almost panic attack levels. No idea what…

> Although there is a link in many cases, there are a lot of cases where there’s no obesity link at all.

I mean, the person you replied to literally said "60% of cases are linked to obesity"

Which obviously implies that 40% of cases are NOT linked to obesity. You are saying the exact same thing the person you replied to is saying, just without the numbers.

I feel like the person you replied to's comment was not stigmatizing obesity at all, in fact learning that 40% of sleep apnea cases are unrelated to obesity entirely probably educated some people that it was less tied to weight than they believed before.

Re: Sleep research led to a new sleep apnea drug

#35

Post by cortesoft »

patrickdavey wrote: post #23
gpt5 wrote: post #2

People should be more aware of the symptoms of sleep apneas - the lack of energy during the day, feeling tired, waking up throughout the night, waking up tired/exhausted, etc. People with untreated sleep apnea have multiple folds higher chances to be depressed, unemployed, and have trouble with basic life functions, in addition to the long term health consequences of depriving your brain from Oxygen. I've suggested 4…

I've tried a CPAP machine for 6 weeks and felt no different and gave up. I think I was a 6 on the scale. I wish it had worked though! Currently I've just given up and embracing feeling relatively tired all the time. I've tried side sleeping devices (woody knows backpack) mandibular advancement splints etc. So hard to tell (I find anyway) to get to a definitive answer

For some people it takes months to feel any different.

For some people, they don't feel any better but it improves their health.

Did you examine your numbers at all in something like OSCAR? You could get a good idea of how many events you were having at night, and if the CPAP was improving it.

Even if you aren't feeling any better (yet) it could still be helping. You could also have multiple things that are causing you fatigue issues, and maybe fixing only one of them wasn't enough... that doesn't mean that one wasn't also important, though.

Re: Sleep research led to a new sleep apnea drug

#36

Post by cortesoft »

anyfoo wrote: post #6
gpt5 wrote: post #2

People should be more aware of the symptoms of sleep apneas - the lack of energy during the day, feeling tired, waking up throughout the night, waking up tired/exhausted, etc. People with untreated sleep apnea have multiple folds higher chances to be depressed, unemployed, and have trouble with basic life functions, in addition to the long term health consequences of depriving your brain from Oxygen. I've suggested 4…

> People should be more aware of the symptoms of sleep apneas I'm always a bit puzzled that this needs to be pointed out? I don't have sleep apnea per se, at least not chronically, but I've definitely had bouts of it due to allergy, sickness, stuff like that. The symptoms are the same because the mechanism is the same: I didn't get enough oxygen in the night. It's always glaringly obvious to me the next day. I feel w…

Couple of things to address here...

One, not all sleep apnea patients snore. 20% do not snore

Second, I am not sure what your experience has to do with people that DO have sleep apnea? If you are correct and you do NOT have chronic sleep apnea, then it makes sense you would notice clearly on the nights you did. For someone who has suffered from it for years (or even their whole life), they aren't going to have anything to compare it to. They don't 'feel way more tired and exhausted' then normal because THIS IS THEIR NORMAL. If everything feels the same as it always feels, why would they assume it was sleep apnea?

Just because you experience something a particular way doesn't mean everyone does

Re: Sleep research led to a new sleep apnea drug

#37

Post by milchek »

I see CPAP rightly getting mentioned a lot here. What worked for me was a MJS (Mandible Jaw Splint), it’s basically a mouthguard you sleep with that moves your lower jaw forward and thus brings your tongue forward so it doesn’t obstruct your airways.

Best bet is to get this custom made. Here in Australia there are specialist dentists that do this for you. It’s far easier than CPAP and works just as well for many like myself.

Often folks will use CPAP at home and these mouth guards when travelling.

Re: Sleep research led to a new sleep apnea drug

#38

Post by calvinmorrison »

gpt5 wrote: post #2

People should be more aware of the symptoms of sleep apneas - the lack of energy during the day, feeling tired, waking up throughout the night, waking up tired/exhausted, etc. People with untreated sleep apnea have multiple folds higher chances to be depressed, unemployed, and have trouble with basic life functions, in addition to the long term health consequences of depriving your brain from Oxygen. I've suggested 4…

#1 symptom - fat necks! if you are like me and had a 17" neck at 185 in high school and now boast a 18.5".... you have it!

Re: Sleep research led to a new sleep apnea drug

#39

Post by gblargg »

anyfoo wrote: post #6
gpt5 wrote: post #2

People should be more aware of the symptoms of sleep apneas - the lack of energy during the day, feeling tired, waking up throughout the night, waking up tired/exhausted, etc. People with untreated sleep apnea have multiple folds higher chances to be depressed, unemployed, and have trouble with basic life functions, in addition to the long term health consequences of depriving your brain from Oxygen. I've suggested 4…

> People should be more aware of the symptoms of sleep apneas I'm always a bit puzzled that this needs to be pointed out? I don't have sleep apnea per se, at least not chronically, but I've definitely had bouts of it due to allergy, sickness, stuff like that. The symptoms are the same because the mechanism is the same: I didn't get enough oxygen in the night. It's always glaringly obvious to me the next day. I feel w…

> > People should be more aware of the symptoms of sleep apneas

>

> I'm always a bit puzzled that this needs to be pointed out?

You're puzzled that most people don't know the symptoms of sleep apnea? Maybe there are big campaigns where you are, but I've never seen any public information about its symptoms.

Re: Sleep research led to a new sleep apnea drug

#40

Post by pmcg »

an0malous wrote: post #29

I went through the whole process of seeing an ENT, using the machine for the at-home sleep study so insurance would give me a CPAP, then not being able to sleep with a CPAP, and over the course of a couple years I fixed my sleep apnea by fixing my posture and breathing. If you have forward head posture or are not used to breathing through your nose, you might also benefit from this. I think it’s kind of crazy that we…

I had a similar experience, with a slightly different approach (mouth tape and a nose dilator) but seemingly similar outcome. I like that you did it just through exercises with no mechanical intervention. Inspiring.
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