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Peptides: where to begin?

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Re: Peptides: where to begin?

#31

Post by Bender »

A_D_E_P_T wrote: post #18
jmye wrote: post #13

Earlier quoted context omitted.

> Drugs risks do not enter into the picture given the fact I can buy ammonia and bleach along with a myriad of other dangerous compounds. This is a deeply weird take. You think anyone ought to be able to buy, for instance, warfarin and freely take it without a doctor’s involvement? We should let parents self-diagnose diabetes and administer insulin without a prescription or discussion? We should just hope that patien…

> This is a deeply weird take. You think anyone ought to be able to buy, for instance, warfarin and freely take it without a doctor’s involvement? We should let parents self-diagnose diabetes and administer insulin without a prescription or discussion? We should just hope that patients heard their doctor say hydralazine and not hydroxyzine? Weird examples. You can buy insulin without a prescription today in the USA.…

In much of the world -- including almost all of Asia, Africa, and much of Eastern Europe

Doctors in the US get a nice $200 to $500 per doctors visit, required to extend the prescription drug. I only notice because I pay cash. This is why they will argue against anything I am saying until they are code-blue in the face. I will leave them with my code brown.

In the US you can get any drug if you pay $120 and recite the magic words to a telemedicine "doctor."

That's how a number of us in a particular circle stock up on anti-biotics. That said anti-biotics are a last resort for me whereas I find doctors are quick to prescribe them.

Re: Peptides: where to begin?

#32

Post by dc396 »

Bender wrote: post #6
A_D_E_P_T wrote: post #4

Earlier quoted context omitted.

> given I eat peptides every day from my food This is briefly addressed in the article, but basically it's one thing to eat a peptide and quite another thing to inject it. Your digestive system is extremely adroit at taking peptides and proteins and breaking them down into individual amino acids, which are then absorbed via "transporters" in the gut. (e.g. SLC6A14 for glutamate and cysteine.) If you eat insulin, abso…

I agree with some of this. There are most certainly orally active peptides such as BPC-157 and its replacement PDA penta deca arginate that can repair the gut and still circulate throughout the body especially in those with leaky gut. People with leaky gut should be able to buy a clean source of BPC-157 or PDA without a prescription and without visiting dark alleys. It is very safe and tolerable. GLP's are all the ra…

> It is very safe and tolerable.

Can you point to the clinical trials that demonstrate this?

> Doctors seem to be giving GLP peptides out like candy and those are injected.

There have been several _thousand_ clinical trials that have shown GLP-1s to be safe and effective.

Re: Peptides: where to begin?

#33

Post by kube-system »

diath wrote: post #29
orf wrote: post #17

Earlier quoted context omitted.

You know dozens of people from a single place that have chronic tendon/joint issues?

Yes? These types of injuries are common among bodybuilders and powerlifters.

Pfft -- they're common among anyone over 30 who exercises!

Re: Peptides: where to begin?

#34

Post by phil21 »

aaarrm wrote: post #22
diath wrote: post #15

> My patient is refusing a drug studied in 170,000 people because of side effects that a 124,000-person analysis just confirmed do not exist — while injecting a compound studied in 14 humans, from unregulated sources, based on the recommendation of someone who profits from selling it. She’s probably not the only one. And those using it believe they are “doing their own research.” Ok, and? At worst you waste a couple…

My partner's grandfather died of cancer because when he was having pains they believed their homeopathic medicine would work. When he finally when in to see a real doctor it was too late. If he had gone in earlier, he would been able to have a chance. This is not a rare occurrence for these types.

Why would you stop going to a real doctor though? It's not one or the other.

I'm very on the fence over BPC-157/TB500, I really want to see some actual clinical trials ran on it. I have a feeling the effects are overstated, but I also have had a number of "insider" conversations where I know these and other compounds are very much being utilized in pro athlete injury recovery programs. Those athletes certainly are getting state of the art medical care via traditional sources, plus elite level physio therapy - so it's hard to say if the illicit injury recovery drugs are doing much or not.

Re: Peptides: where to begin?

#35

Post by hombre_fatal »

A_D_E_P_T wrote: post #27
jmye wrote: post #7

Earlier quoted context omitted.

> Another point I could raise is that telemedicine has turned the entire prescription system into nothing more than a parasitic middleman/gatekeeper. I’m curious what you mean by this. I’m not sure what you mean by “prescription system” specifically.

I'll give you a case in point. This article was discussed the other day: > https://www.nytimes.com/2026/04/02/technology/ai-billion-dol... People want GLP-1 drugs. They can't get them without a prescription. They pay $$$ to a "telemedicine" "doctor", recite a list of well-known symptoms, and buy the prescription. The system is that you can't buy these drugs without the piece of paper, and the piece of paper is basica…

I think access is a good thing. The issue isn't with telemedicine but the fact that there's a prescription wall for helpful meds like GLP-1 in a country where we've failed people by creating one of the worst food environments.

Also, most doctor's visits aren't any different from getting it if you want it except it's gated on the mood/attitude of the doctor, maybe your ability to sell some sob story. And then you book a different doctor until you get it. Telemedicine just makes the process easier an arbitrary system.

Re: Peptides: where to begin?

#36

Post by olalonde »

The author is missing a massive segment of that gray market: people who buy FDA-approved weight loss drugs (e.g., semaglutide or tirzepatide) at 2–5% of the brand-name price. This route carries some risk, but there are ways to mitigate it, such as performing third-party testing. I assume most people who do this couldn't realistically afford the brand-name drug anyway, making this their only viable treatment.

Re: Peptides: where to begin?

#37

Post by [deleted] »

jmye wrote: post #13
Bender wrote: post #3

It seems we are treating Peptides like drugs here. It's my opinion that amino acids regardless of how they are chained do not belong under and stricter regulation than food given I eat peptides every day from my food. Then again I do not believe in the concept of prescription drugs. Everything with a NDC code should be at the grocery store and I should be able to stock up on it without permission especially given how…

> Drugs risks do not enter into the picture given the fact I can buy ammonia and bleach along with a myriad of other dangerous compounds. This is a deeply weird take. You think anyone ought to be able to buy, for instance, warfarin and freely take it without a doctor’s involvement? We should let parents self-diagnose diabetes and administer insulin without a prescription or discussion? We should just hope that patien…

[deleted]

Re: Peptides: where to begin?

#38

Post by hammock »

cwmoore wrote: post #8
A_D_E_P_T wrote: post #2

Lowe has a point, but the FDA has painted itself into a corner by (a) forcing up the costs and the various bureaucratic demands associated with clinical trials, (b) allowing drug advertising , but then forcing those comical "may cause death" disclaimers, both of which have become totally ubiquitous, and (c) inconsistently following its own rules, and in some cases flouting its own rules. At this point, broscience is…

When medicine ignores nutrition entirely, and nutrient supplements are still complete unknowns, you have to wonder who the FDA is working for.

You don’t have to wonder. It’s public record that 45% of the FDA’s budget incomes from user fees that companies pay when they apply for approval of a medical device or drug.

In the drug division specifically, the number is about 75%.

Re: Peptides: where to begin?

#39

Post by comrade1234 »

I know a couple of people that should know better (phds in biosciences but now doing corporate management) taking expensive weird Chinese peptides that would probably be better off if they did some cardio a few days per week and ate better.

Re: Peptides: where to begin?

#40

Post by pedalpete »

jmye wrote: post #7
A_D_E_P_T wrote: post #2

Lowe has a point, but the FDA has painted itself into a corner by (a) forcing up the costs and the various bureaucratic demands associated with clinical trials, (b) allowing drug advertising , but then forcing those comical "may cause death" disclaimers, both of which have become totally ubiquitous, and (c) inconsistently following its own rules, and in some cases flouting its own rules. At this point, broscience is…

> Another point I could raise is that telemedicine has turned the entire prescription system into nothing more than a parasitic middleman/gatekeeper. I’m curious what you mean by this. I’m not sure what you mean by “prescription system” specifically.

The "perscription system" used to be that you'd have to go see a doctor, the doctor knew who you were, and would make decisions on what prescriptions/medications you should be given.

Due to drug advertising rules, the prescription system has been turned on its head, and the patient now goes to their doctor asking for a specific prescription.

Telemedicine took advantage of this and has effectively removed the middleman (the doctor) in many cases and you just sign-up look at a person on a camera, and get your drugs sent to you.

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