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Discontinuation and reinitiation of dual-labeled GLP-1 receptor agonists

nautil.us

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Re: Discontinuation and reinitiation of dual-labeled GLP-1 receptor agonists

#31

Post by brap »

Teknoman117 wrote: post #26

I’m always kind of envious of the people who were able to lose weight on GLP-1 drugs. I lost a bunch of weight a few years ago, and still need to lose a lot more (430 lb -> 330, goal 240), but I fell out of the good habits for, well, no good reasons… Decided to try Ozempic and was on it for about 6 months. Didn’t do a single thing for my appetite unfortunately, even on the max dose. Sample size of one here, but if yo…

Wegovy/Ozempic didn’t do anything for me for months. Then my doc put me on Tirzepatide+Phentermine combo and I forgot what being hungry even feels like.

Re: Discontinuation and reinitiation of dual-labeled GLP-1 receptor agonists

#32

Post by mh- »

devin wrote: post #21
Aboutplants wrote: post #20

The most capitalistic drug ever! Take the drug forever and lose weight but stop taking it and you’ll die.

That isn’t what this says at all.

(off-topic, but since the thread already is..)

HN felt like one of the last places on the internet I could have good-faith conversations with intelligent people who would form thoughtful, on-topic replies.

And now it feels like the user base here has shifted enough that the voting system no longer consistently elevates the interesting comments, but the comments that reinforce people's worldviews.

Re: Discontinuation and reinitiation of dual-labeled GLP-1 receptor agonists

#33

Post by cthalupa »

jryio wrote: post #10

We finally found the first morbidity signal of GLP-1s (or lack thereof). These are life changing drugs, but like plastic we'll see their effects in force within this generation: > The longer time spent off GLP-1s, the greater the risk of major cardiovascular events—up to 22 percent for those who abstained for two years.

You are misunderstanding the study (largely because the article heavily misrepresents it, would be my guess)

They do not see an increase against their pre-GLP1 baseline risk - they see a reversal of the cardioprotective benefits the drug provided while they were on it.

Re: Discontinuation and reinitiation of dual-labeled GLP-1 receptor agonists

#34

Post by amelius »

Teknoman117 wrote: post #26

I’m always kind of envious of the people who were able to lose weight on GLP-1 drugs. I lost a bunch of weight a few years ago, and still need to lose a lot more (430 lb -> 330, goal 240), but I fell out of the good habits for, well, no good reasons… Decided to try Ozempic and was on it for about 6 months. Didn’t do a single thing for my appetite unfortunately, even on the max dose. Sample size of one here, but if yo…

Did you try those zero-sugar candy bars (often labeled as protein bars)? They work quite well for me, no messing with GLP-1 necessary.

Re: Discontinuation and reinitiation of dual-labeled GLP-1 receptor agonists

#35

Post by j-conn »

amelius wrote: post #34
Teknoman117 wrote: post #26

I’m always kind of envious of the people who were able to lose weight on GLP-1 drugs. I lost a bunch of weight a few years ago, and still need to lose a lot more (430 lb -> 330, goal 240), but I fell out of the good habits for, well, no good reasons… Decided to try Ozempic and was on it for about 6 months. Didn’t do a single thing for my appetite unfortunately, even on the max dose. Sample size of one here, but if yo…

Did you try those zero-sugar candy bars (often labeled as protein bars)? They work quite well for me, no messing with GLP-1 necessary.

Which do you like? Barebells salty peanut and chocolate dough over here. Though the sugar alcohols certainly aren’t great for you either, I think they were recently linked to stroke risk

Re: Discontinuation and reinitiation of dual-labeled GLP-1 receptor agonists

#36

Post by 01100011 »

Teknoman117 wrote: post #26

I’m always kind of envious of the people who were able to lose weight on GLP-1 drugs. I lost a bunch of weight a few years ago, and still need to lose a lot more (430 lb -> 330, goal 240), but I fell out of the good habits for, well, no good reasons… Decided to try Ozempic and was on it for about 6 months. Didn’t do a single thing for my appetite unfortunately, even on the max dose. Sample size of one here, but if yo…

It lets me more or less skip a meal but holy hell I am craving sugar more than ever. On the whole I'm cutting calories and have lost a lot of weight, I just wish I didn't want sugar this much.

Re: Discontinuation and reinitiation of dual-labeled GLP-1 receptor agonists

#37

Post by amazingamazing »

Honestly don’t understand it. Feels like a lack of discipline. I was 250. Plugged in a bunch of numbers into an app and it gave me a calorie count per day. I brought a scale with me everywhere, used ChatGPT to guesstimate calories, I added 50% for good measure. A year later I’m 175. You can’t do this even with drugs you’re gonna get fat anyway.

I’m most curious about someone like me vs someone who lost the same amount on glp1 with respect to these stats

Re: Discontinuation and reinitiation of dual-labeled GLP-1 receptor agonists

#38

Post by TaupeRanger »

jryio wrote: post #10

We finally found the first morbidity signal of GLP-1s (or lack thereof). These are life changing drugs, but like plastic we'll see their effects in force within this generation: > The longer time spent off GLP-1s, the greater the risk of major cardiovascular events—up to 22 percent for those who abstained for two years.

You failed to understand the results of the study and quoted a passage that does not in any way support your assertion.

Re: Discontinuation and reinitiation of dual-labeled GLP-1 receptor agonists

#39

Post by TaupeRanger »

mh- wrote: post #32
devin wrote: post #21

Earlier quoted context omitted.

That isn’t what this says at all.

(off-topic, but since the thread already is..) HN felt like one of the last places on the internet I could have good-faith conversations with intelligent people who would form thoughtful, on-topic replies. And now it feels like the user base here has shifted enough that the voting system no longer consistently elevates the interesting comments, but the comments that reinforce people's worldviews.

What do you mean? All of the comments that misunderstand the study are downvoted from what I see.

Re: Discontinuation and reinitiation of dual-labeled GLP-1 receptor agonists

#40

Post by Teknoman117 »

01100011 wrote: post #36
Teknoman117 wrote: post #26

I’m always kind of envious of the people who were able to lose weight on GLP-1 drugs. I lost a bunch of weight a few years ago, and still need to lose a lot more (430 lb -> 330, goal 240), but I fell out of the good habits for, well, no good reasons… Decided to try Ozempic and was on it for about 6 months. Didn’t do a single thing for my appetite unfortunately, even on the max dose. Sample size of one here, but if yo…

It lets me more or less skip a meal but holy hell I am craving sugar more than ever. On the whole I'm cutting calories and have lost a lot of weight, I just wish I didn't want sugar this much.

I’ve always been more of a savory kind of person myself. I’d take biscuits and gravy or a steak over sweets any day!

But I feel you on sugar. Took me a long time to cut sugar cravings. A decade ago I cut regular soda out of my diet, which a few years later led to me cutting out pretty much anything sweetened. Realistically it wasn’t the sweetness for me, it was the “mouthfeel” or doing something with your mouth. Just straight sparkling water satisfied the entire craving for me.

The hardest thing for me to give up / heavily cut back on was fried things. Maybe that’s the result of my parents using french fries as the reward food when I was a kid…

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