31–40 of 122 posts
I only had time to skim the paper. Notably, the effect is concentration dependent and required high concentrations of THC. The chart shows it really starting in the 0.1uM range and then taking off in the 1uM range. I don’t know what levels are achieved during normal use but I did find some studies that successfully killed a lot of hippocampal neuronal cells after 6 days at 1uM range. So the levels of THC observed in…
Too bad we've had like a half-dozen putative Alzheimer's drugs that clear amyloid beta that turn out to do nothing to slow or prevent Alzheimer's. Actually, I think even by 2016 we already had enough phase 3 drug failures that the amyloid hypothesis was severely called into question?
Do we still think clearing beta amyloid plaques will halt the progress of Alzheimer's? My impression is we're treating marker for the disease and not the cause.
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I've tried everything and I still get panic attacks. I used to love smoking a small hitter about an hour before bed. I've always had insomnia and that was the one thing that actually helped me sleep. When it was illegal, I loved it. I would smoke 2 or 3 times a week just for sleep, and I was healthy and happy. . . Because sleep is important, and I never wanted to take sleeping pills because dependency. Now that it's…
Always thought that panic attacks were caused by too low CBD in regards to THC levels. Saw someone literally suggesting keeping a CBD vape pen just in case of a panic attack. Or a friend using it for heart palpitations. Wasn't the amount of THC concentration in resin seen as the indicator of potency? Then that amount was hacked through selective breeding, unbeknownst that not following with a complementary increase i…
Remove them and replace them with...Doritos?
I seem to have touched a nerve. In my defense, it may have been a stupid joke but it's not as stupid as trying to prevent brain damage by taking cannabinoids at levels known to cause brain damage.
Here. Take my upvotes to balance it out a smidge.
I only had time to skim the paper. Notably, the effect is concentration dependent and required high concentrations of THC. The chart shows it really starting in the 0.1uM range and then taking off in the 1uM range. I don’t know what levels are achieved during normal use but I did find some studies that successfully killed a lot of hippocampal neuronal cells after 6 days at 1uM range. So the levels of THC observed in…
Can't have Alzheimer's if you don't have much of a brain left.
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Have you tried L-theanine? I also get panic attacks with weed, but L-theanine seems to help keep them at bay.
I've tried everything and I still get panic attacks. I used to love smoking a small hitter about an hour before bed. I've always had insomnia and that was the one thing that actually helped me sleep. When it was illegal, I loved it. I would smoke 2 or 3 times a week just for sleep, and I was healthy and happy. . . Because sleep is important, and I never wanted to take sleeping pills because dependency. Now that it's…
A couple years ago (around 40) I started taking a low dose antidepressant for unrelated reasons and noticed that the weed induced anxiety mostly disappeared. My guess is that for some people there’s a serotonin/anxiety component that THC can amplify, but that’s just speculation on my part.
Not suggesting antidepressants as a solution by themselves. They come with their own tradeoffs and I wouldn’t take them just for that. But it has been a pleasant side effect I didn’t expect.
Earlier quoted context omitted.
Have you tried L-theanine? I also get panic attacks with weed, but L-theanine seems to help keep them at bay.
I've tried everything and I still get panic attacks. I used to love smoking a small hitter about an hour before bed. I've always had insomnia and that was the one thing that actually helped me sleep. When it was illegal, I loved it. I would smoke 2 or 3 times a week just for sleep, and I was healthy and happy. . . Because sleep is important, and I never wanted to take sleeping pills because dependency. Now that it's…
I feel like that strain is for EXPERTS. You can always mold it to the vibe you are aiming to reach in that present (ofc in the appropriate environments).
Do you feel like the anxiety just the cascaded result of ... "poor planning" over an extended, day-over-day staggering, sleep-deprived, period of time? I consider my self naturally the poorest of poor planners. My brain is just RAM with zero cache that i always imagine that I have. I've had weeks wiz by if I do not get on top of a fun, MJ propagandized base routine / schedule in place.
Apologies! Worse case, this could just be a swing and a miss. Empathies attempted.
Earlier quoted context omitted.
I've tried everything and I still get panic attacks. I used to love smoking a small hitter about an hour before bed. I've always had insomnia and that was the one thing that actually helped me sleep. When it was illegal, I loved it. I would smoke 2 or 3 times a week just for sleep, and I was healthy and happy. . . Because sleep is important, and I never wanted to take sleeping pills because dependency. Now that it's…
So, I sort of get these from time to time, but I notice that it hits the worst when : 1. I've eaten like crap. Things too heavy I'm grease, processed food, and red meats. When I'm rating cleaner, I don't feel as panicky 2. If I feel the panic coming on, I HAVE to do some sort of aerobic exercise in that first 15 minute "induction" phase of smoking. Otherwise I'll carry the panic along through the entire session. FWIW…
5km goes by fast! And orange juice tastes great after.