After the Civil War, nearly all states gave up on maintaining their own independent militia and they became the National Guard (a few states maintain poorly provisioned state guards). Ostensibly the Guard is run by the states but can be federalized at any time. Previous presidents only used that to deploy the Guard overseas, with a few exceptions (notably Eisenhower, to enforce the early civil rights legislation and court decisions). Unfortunately those powers were never reformed, so Trump has already deployed them domestically (though there have been court decisions against that), but it effectively means states can't use the Guard to protect against federal aggression (it would simply be immediately federalized). Any attempt to actually deploy state troops against federal law enforcement, even when they're aren't justly enforcing laws, would be met with the Insurrection Act, allowing the deployment of active duty troops against the states, not just the Guard. Trump has been eagerly awaiting that moment, as it would allow him to completely cut the state off from the rest of the country, including Congress (you're in rebellion, you have no representation), and lock their elections in legal limbo.
Nowadays, the 2A is used simply to guarantee gun access to individuals, a movement underway since the early civil rights movement in the late '50s and largely confirmed with the Heller decision in '08. Unfortunately, that movement didn't bring any right to actually resist government overreach, which is why we haven't seen citizen militias form to violently resist ICE's own violence. They'd simply be killed and imprisoned and used to justify an increase in violence.
Personally, these events have really exposed the moral bankruptcy of the modern 2A movement. They want guns, and the attendant increase in shootings that accompany that, but have brought no real ability to resist government violence along with it. So we have the negative without the purported positive.
Obviously the next Congress and President will need to reform how the Guard works and how it can be deployed, otherwise we'll see this again.