https://pmc.ncbi.nlm.nih.gov/articles/PMC12713542/
(without paywall)
Scientists edited genes in a living person and saved his life
31–40 of 47 posts
Re: Scientists edited genes in a living person and saved his life
#32Your genes seem to be out of date, there are several security updates pending. The download will be 3.2 Gb and will take about 3 seconds..... Because this is a security update you can not refuse it. If you are commanding a vehicle park it now or switch to autopilot. Commencing update in 10, 9, 8, ...
I updated to version 10.5.7 and now I see Samsung ads in my peripheral vision, wtf
Re: Scientists edited genes in a living person and saved his life
#33Very dumb question, but how exactly does gene therapy work in vivo? Don't you have to modify every cell (or affected type of cell) with a new copy of the DNA? How does that actually.... happen?
> Don't you have to modify every cell (or affected type of cell) with a new copy of the DNA?
It depends on the specific disorder that’s being treated. For some of them, targeting a fraction of the affected cells is enough to get the desired effect.
Re: Scientists edited genes in a living person and saved his life
#34There was a guy on YouTube who genetically engineered himself to gain lactose tolerance. ( https://www.youtube.com/watch?v=J3FcbFqSoQY ) It lasted for around a year and a half ( https://www.youtube.com/watch?v=aoczYXJeMY4 ) before the effect mostly wore off. He took it orally, so it only affected his intestinal lining, and I presume it didn't effect enough stem cells to get a permanent effect, but it would still be u…
̶I̶ ̶t̶h̶i̶n̶k̶ ̶h̶e̶ ̶a̶c̶t̶u̶a̶l̶l̶y̶ ̶g̶e̶n̶e̶t̶i̶c̶a̶l̶l̶y̶ ̶e̶n̶g̶i̶n̶e̶e̶r̶e̶d̶ ̶h̶i̶s̶ ̶g̶u̶t̶ ̶b̶a̶c̶t̶e̶r̶i̶a̶ ̶r̶a̶t̶h̶e̶r̶ ̶t̶h̶a̶n̶ ̶a̶n̶y̶ ̶o̶f̶ ̶h̶i̶s̶ ̶o̶w̶n̶ ̶c̶e̶l̶l̶s̶ ̶t̶h̶e̶r̶e̶,̶ ̶r̶i̶g̶h̶t̶?̶ EDIT: Above is false. Went back and checked and I had mis-remembered the video.
Is there a reason why I'm seeing squares between each of the characters in your message? It's making it pretty hard to read...
I'm using Chrome on Android
Re: Scientists edited genes in a living person and saved his life
#35Earlier quoted context omitted.
̶I̶ ̶t̶h̶i̶n̶k̶ ̶h̶e̶ ̶a̶c̶t̶u̶a̶l̶l̶y̶ ̶g̶e̶n̶e̶t̶i̶c̶a̶l̶l̶y̶ ̶e̶n̶g̶i̶n̶e̶e̶r̶e̶d̶ ̶h̶i̶s̶ ̶g̶u̶t̶ ̶b̶a̶c̶t̶e̶r̶i̶a̶ ̶r̶a̶t̶h̶e̶r̶ ̶t̶h̶a̶n̶ ̶a̶n̶y̶ ̶o̶f̶ ̶h̶i̶s̶ ̶o̶w̶n̶ ̶c̶e̶l̶l̶s̶ ̶t̶h̶e̶r̶e̶,̶ ̶r̶i̶g̶h̶t̶?̶ EDIT: Above is false. Went back and checked and I had mis-remembered the video.
Is there a reason why I'm seeing squares between each of the characters in your message? It's making it pretty hard to read... I'm using Chrome on Android
Firefox on iOS, I see strikethrough but the strikes are at varying heights.
Re: Scientists edited genes in a living person and saved his life
#36There was a guy on YouTube who genetically engineered himself to gain lactose tolerance. ( https://www.youtube.com/watch?v=J3FcbFqSoQY ) It lasted for around a year and a half ( https://www.youtube.com/watch?v=aoczYXJeMY4 ) before the effect mostly wore off. He took it orally, so it only affected his intestinal lining, and I presume it didn't effect enough stem cells to get a permanent effect, but it would still be u…
I thought (maybe mistakenly) that your body developed immunity to the adenovirus used to edit your own DNA, and so this trick could only be used once? Am I wrong?
In this specific instance the code he built used a non-human lactase-enzyme producing gene, which he states in the retrospective is very likely the reason why his immune cells started attacking. There was also the matter of some of the other coding pieces being non-ideal.
Re: Scientists edited genes in a living person and saved his life
#37Your genes seem to be out of date, there are several security updates pending. The download will be 3.2 Gb and will take about 3 seconds..... Because this is a security update you can not refuse it. If you are commanding a vehicle park it now or switch to autopilot. Commencing update in 10, 9, 8, ...
I updated to version 10.5.7 and now I see Samsung ads in my peripheral vision, wtf
You're the lucky one... they're a/b testing this and I get them flashing full size for a half second twice a day. I've tried blocking them at the firewall but their AI is so good now it can hack that in a couple of seconds, and they're using what I've seen as input to their bypass. It won't be long before we won't be able to turn it off at all. Joe Jackson saw it coming...
Re: Scientists edited genes in a living person and saved his life
#38What worries me is the attacks on universities and the breaking of public private research based on this comment from the article: "In a race against time, scientists and doctors across the U.S. developed the first in vivo gene therapy, thanks to decades of medical research."
Unfortunately one of the common responses is "cancer is still deadly doesn't seem like they're doing anything but getting rich". These therapies aren't widely known and people are willing to throw them out for that reason.
Re: Scientists edited genes in a living person and saved his life
#39There was a guy on YouTube who genetically engineered himself to gain lactose tolerance. ( https://www.youtube.com/watch?v=J3FcbFqSoQY ) It lasted for around a year and a half ( https://www.youtube.com/watch?v=aoczYXJeMY4 ) before the effect mostly wore off. He took it orally, so it only affected his intestinal lining, and I presume it didn't effect enough stem cells to get a permanent effect, but it would still be u…
Wow this is amazing. Definitely the best biology video I've seen. Edit: this is cool enough to deserve it’s own post, Im going to submit it: https://news.ycombinator.com/item?id=46405855
Agreed. If this isn't hacking then I don't know what is.
Re: Scientists edited genes in a living person and saved his life
#40That's promising.
Where do I sign up?
I need my entire DNA code reprogrammed :)