Earlier quoted context omitted.
I'd love to see some benchmarks for this on some common genomic formats (fa, fq, sam, vcf). Will be doubly interesting to see its applicability to nanopore data - lots of useful data is lost because storing FAST5/POD5 is a pain.
And a comparison between CRAM and openzl on a sam/bam file. Is openzl indexable, where you can just extract and decompress the data you need from a file if you know where it is?
Not today. However, we are considering this as we are continuing to evolve the frame format, and it is likely we will add this feature in the future.