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Woman takes 10x dose of turmeric, gets hospitalized for liver damage

arstechnica.com

31–40 of 74 posts

Re: Woman takes 10x dose of turmeric, gets hospitalized for liver damage

#31
post #22

> she began taking turmeric capsules at a dose of 2,250 mg per day. That's a teaspoon. The average South-east asian eats close to that much in a day for their entire lives.

I think that's 2.2g curcumin. Powdered turmeric, the spice, contains approximately 3% curcumin by weight. So one teaspoon turmeric sounds like it's pretty close to the RDA.

The article very clearly states that she was taking turmeric supplement, not curcumin.

Re: Woman takes 10x dose of turmeric, gets hospitalized for liver damage

#33
post #6

So I live in the EU where such supplements are supposedly safe. Article said that supplements that mix pepper and turmeric are dangerous. And the dose that was dangerous to the woman was 2000mg. I looked on my table toward the bottle of turmeric my parents gifted me recently, saying they heard it was good and bought on a famous "health" store. Bottle is: turmeric + pepper "designed for max absorption" and dose is 100…

Secondarily, both contains oxalate in proportions of 1% of black pepper and 2% of turmeric by mass, which leads to the formation of kidney stones. It's worse in the US because the FDA effectively "washes its hands" of anything deemed a "supplement". In general, the precautionary principle is difficult to find in America outside of FDA-approved procedures, medical devices, and medications. Food and supplements are des…

> "It's worse in the US because the FDA effectively "washes its hands" of anything deemed a "supplement""

The "natural" supplement industry lobbied for, and obtained, a law that makes them unregulatable.

https://en.wikipedia.org/wiki/Dietary_Supplement_Health_and_... ("Dietary Supplement Health and Education Act of 1994")

> "The act was intended to exempt the dietary and herbal supplement industry from most FDA drug regulations, allowing them to be sold and marketed without scientific backing for their health and medical claims.[3]"

Re: Woman takes 10x dose of turmeric, gets hospitalized for liver damage

#34
post #6

So I live in the EU where such supplements are supposedly safe. Article said that supplements that mix pepper and turmeric are dangerous. And the dose that was dangerous to the woman was 2000mg. I looked on my table toward the bottle of turmeric my parents gifted me recently, saying they heard it was good and bought on a famous "health" store. Bottle is: turmeric + pepper "designed for max absorption" and dose is 100…

Are you sure it’s not microgram (μg)?

Re: Woman takes 10x dose of turmeric, gets hospitalized for liver damage

#35
post #20
post #6

So I live in the EU where such supplements are supposedly safe. Article said that supplements that mix pepper and turmeric are dangerous. And the dose that was dangerous to the woman was 2000mg. I looked on my table toward the bottle of turmeric my parents gifted me recently, saying they heard it was good and bought on a famous "health" store. Bottle is: turmeric + pepper "designed for max absorption" and dose is 100…

Why would supplements supposedly be safe in the EU? They are not regulated as far as I know? They can be sold anywhere. They often contain all kinds of inflated claims..

Not sure why this is downvoted, it's exactly correct. Supplements are entirely unregulated, and actually often not even sold as food/medicine "officially", but labeled as "collectible item". Light drugs are often sold this way too (kratom, HHC weed, etc).

Re: Woman takes 10x dose of turmeric, gets hospitalized for liver damage

#36

> According to the World Health Organization, an acceptable daily dose is up to 3 mg per kilogram of weight per day—for a 150-pound (68 kg) adult, that would be about 204 mg per day. Mohan was taking more than 10 times that amount I think it's extremely likely that the majority of people in India and surrounding countries - so, hundreds of millions of people - far exceeds the WHO recommendation every day, and frequen…

The 3mg per kg per day is of curcumin not turmeric itself. Looking up the content of curcumin in turmeric powder it seems to average around ~1-2% so 2-2.5g of turmeric per day would be 25-50mg of curcumin.

Re: Woman takes 10x dose of turmeric, gets hospitalized for liver damage

#37

> According to the World Health Organization, an acceptable daily dose is up to 3 mg per kilogram of weight per day—for a 150-pound (68 kg) adult, that would be about 204 mg per day. Mohan was taking more than 10 times that amount I think it's extremely likely that the majority of people in India and surrounding countries - so, hundreds of millions of people - far exceeds the WHO recommendation every day, and frequen…

You're conflating turmeric with the bioactive chemical component in turmeric, curcumin: the toxicology figures refer to the latter.

(To be fair, the Ars Technica article fails the reader by failing to use precise language, inviting dangerous misunderstandings).

Re: Woman takes 10x dose of turmeric, gets hospitalized for liver damage

#38
post #4

Mohan vowed: "I’ll never put another supplement in my body again." Maybe just don't do such large doses?

> Maybe just don't do such large doses? Yeah. Isn't there a thing called water poisoning? Where your body sheds lots of things that it needs if you drink too much water? I'd wager a guess that if you drink >20 liters of water daily you'll be in some trouble...

Iirc kidney rate is 0.8-1L per hour, so at 20L/day the person would be fairly likely to hit hyponatremia rather quickly.

Weasel words included because they're necessary... Health is complicated

Re: Woman takes 10x dose of turmeric, gets hospitalized for liver damage

#39
post #36

> According to the World Health Organization, an acceptable daily dose is up to 3 mg per kilogram of weight per day—for a 150-pound (68 kg) adult, that would be about 204 mg per day. Mohan was taking more than 10 times that amount I think it's extremely likely that the majority of people in India and surrounding countries - so, hundreds of millions of people - far exceeds the WHO recommendation every day, and frequen…

The 3mg per kg per day is of curcumin not turmeric itself. Looking up the content of curcumin in turmeric powder it seems to average around ~1-2% so 2-2.5g of turmeric per day would be 25-50mg of curcumin.

Except the article didn't mention she was taking curcumin but turmeric. Sloppy journalism could also be a culprit.

Re: Woman takes 10x dose of turmeric, gets hospitalized for liver damage

#40

> According to the World Health Organization, an acceptable daily dose is up to 3 mg per kilogram of weight per day—for a 150-pound (68 kg) adult, that would be about 204 mg per day. Mohan was taking more than 10 times that amount I think it's extremely likely that the majority of people in India and surrounding countries - so, hundreds of millions of people - far exceeds the WHO recommendation every day, and frequen…

> contamination

Well, turmeric certainly has a history of “contamination”[1].

[1] https://www.npr.org/sections/goats-and-soda/2024/09/23/nx-s1...

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