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Continuous glucose monitors reveal variable glucose responses to the same meals

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Re: Continuous glucose monitors reveal variable glucose responses to the same meals

#31

Post by coldpie »

taeric wrote: post #5

Odd, I would have expected this to be somewhat the case? Specifically, I would expect your activity leading into the meals, along with your expectations of what you will be doing after, would have some impact? Probably more impact from how hungry you were going into a meal. If you were already sated, for example, I'd expect your body to largely try and push the meal through as fast as it can. Neat to see what other p…

> Odd, I would have expected this to be somewhat the case?

I don't think anybody was expecting to be surprised by this study. In practice, most science is pretty boring and rarely breaks expectations. But being unsurprising does not mean it's not worth doing. A lot of studies are simply validating expected outcomes and providing foundational data points for future studies to refer back to. For example, a future study might use this study to justify funding ("as shown in Study 2025.abcd, glucose is highly variable... we propose to further study this by controlling for ... which will help us understand the influence of ..." etc etc).

Re: Continuous glucose monitors reveal variable glucose responses to the same meals

#32

Post by jzacharia »

ddorian43 wrote: post #26
jzacharia wrote: post #21

Earlier quoted context omitted.

Keto works well, but I'm concerned about the extreme fat intake. I did manage to lower my A1C from 9s to mid 5s using Keto as a T1D, but eventually settled into a high protein, moderate fat, low-ish carb diet and that has worked pretty well without being hyper-restrictive. Heavily inspired by the late Dr. Richard K. Bernstein.

I target for high ketones (1.5+) & low glucose 4-5mmol (blood test 1 hour after wake up) and higher protein interferes with both of them.

Curious - what's the reason for targeting ketone levels?

Re: Continuous glucose monitors reveal variable glucose responses to the same meals

#33

Post by taeric »

coldpie wrote: post #31
taeric wrote: post #5

Odd, I would have expected this to be somewhat the case? Specifically, I would expect your activity leading into the meals, along with your expectations of what you will be doing after, would have some impact? Probably more impact from how hungry you were going into a meal. If you were already sated, for example, I'd expect your body to largely try and push the meal through as fast as it can. Neat to see what other p…

> Odd, I would have expected this to be somewhat the case? I don't think anybody was expecting to be surprised by this study. In practice, most science is pretty boring and rarely breaks expectations. But being unsurprising does not mean it's not worth doing. A lot of studies are simply validating expected outcomes and providing foundational data points for future studies to refer back to. For example, a future study…

Ah, great point! I definitely got the impression that this was a surprise, but I can't say why I got that impression. That said, I did not intend this as a criticism of running the study! Quite the contrary, glad they did it. I was only meaning my comment to be contra the sense of surprise I had.

Re: Continuous glucose monitors reveal variable glucose responses to the same meals

#34

Post by ddorian43 »

jzacharia wrote: post #32
ddorian43 wrote: post #26

Earlier quoted context omitted.

I target for high ketones (1.5+) & low glucose 4-5mmol (blood test 1 hour after wake up) and higher protein interferes with both of them.

Curious - what's the reason for targeting ketone levels?

Better mental health.

Re: Continuous glucose monitors reveal variable glucose responses to the same meals

#35

Post by coldpie »

taeric wrote: post #33
coldpie wrote: post #31

Earlier quoted context omitted.

> Odd, I would have expected this to be somewhat the case? I don't think anybody was expecting to be surprised by this study. In practice, most science is pretty boring and rarely breaks expectations. But being unsurprising does not mean it's not worth doing. A lot of studies are simply validating expected outcomes and providing foundational data points for future studies to refer back to. For example, a future study…

Ah, great point! I definitely got the impression that this was a surprise, but I can't say why I got that impression. That said, I did not intend this as a criticism of running the study! Quite the contrary, glad they did it. I was only meaning my comment to be contra the sense of surprise I had.

It's a pretty common reaction :)

https://news.ycombinator.com/item?id=43964238

https://news.ycombinator.com/item?id=43964122

https://news.ycombinator.com/item?id=43964428

https://news.ycombinator.com/item?id=43963196

Re: Continuous glucose monitors reveal variable glucose responses to the same meals

#36

Post by pfortuny »

taeric wrote: post #16
pfortuny wrote: post #13

Earlier quoted context omitted.

People think medicine is Physics. They really do.

I think I agree with the idea you are saying. That people think you can formulate our body to ignore a lot of the state that it holds. I'll note that even basic physics has that problem. Try explaining to a 5th grader why a feather would fly in the same arc that a rock will take, if there was no air.

Well, I did not want to say "Mathematics" because it sounded a bit exaggerated. Of course you are right.

Re: Continuous glucose monitors reveal variable glucose responses to the same meals

#38

Post by mikelward »

je42 wrote: post #25
stranded22 wrote: post #6

Yep. My wife is T1D and this is infuriating for her. She’ll think that she’s cracked it, and then the next day, with the same meal at the same time, her sugar levels go high. Her words: there is nothing else where you have studied for over 30 years and STILL feel like you know nothing. It is incredibly demoralising for her sometimes - especially when she’s suffering also from a high/low sugar level. I have the upmost…

More data can help inform semi closed loop systems to deal with this variability. For example, AAPS has since version 3.2 dynamic IFS. ( https://androidaps.readthedocs.io/en/latest/DailyLifeWithAap... ) For me this works quite well

*ISF (Insulin Sensitivity Factor)

Re: Continuous glucose monitors reveal variable glucose responses to the same meals

#39

Post by kesor »

csours wrote: post #8

Some assumptions are so obvious no one bothers to state them, or even remember them. Assumption: Medical professionals are trained to use Evidence Based Medicine (EBM). One might assume that EBM means something specific, and I'm sure it does, but that specific thing is different for different people. One thing that EBM sometimes means is: common sense is no substitute for evidence. There are uncountable times that co…

The map is not the territory, if only more professionals and doctors read some Alfred Korzybski, the world would have been a better place.

Re: Continuous glucose monitors reveal variable glucose responses to the same meals

#40

Post by nradov »

blindriver wrote: post #30
bilsbie wrote: post #28

Earlier quoted context omitted.

Interesting. What’s your a1c level ? I think you could have a point at around 100-105 baseline but 120 seems too high.

It's high, like 6.7-6.9. It doesn't make sense to me because that would suggest average blood glucose of over 150, but it's objectively around 120.

There is some genetic variability in the correlation between blood glucose versus HbA1c. The HbA1c test is essentially an integrator of blood glucose level over time but different people have different average red blood cell lifespans.
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