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GLP-1 drugs: An economic disruptor? (2024)

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Re: GLP-1 drugs: An economic disruptor? (2024)

#31

Post by thundergolfer »

Marsymars wrote: post #24
aljgz wrote: post #14

> When companies like Google see their healthcare costs drop by $12,000 per employee annually and productivity increase by 25%, we observe a restructuring of corporate America that makes remote work a minor adjustment. In my entire office, there's one overweight person that I know. Out of thousands of employees. There could be more, and other cities might be different, but you get the idea. The author intentionally o…

> In my entire office, there's one overweight person that I know. Out of thousands of employees. That seems incompatible with the numbers that show something like 3/4 of the US population being overweight. (And yeah, BMI isn't great, but it works pretty well with an aggregate population of sedentary individuals, which the population at large is.)

The population of a specific Google office could be two std deviations from the mean. My office area, SoHo NYC, has a dramatically lower obesity rate than the USA average. Maybe 10-20% of the population is overweight, let alone obese, and it’s mostly the service workers.

Re: GLP-1 drugs: An economic disruptor? (2024)

#34

Post by devmor »

cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

> Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to forget to eat.

This is the largest of several reasons I hesitate to try it for myself. I am a very big guy (I would be about 184lbs if I had 0% bodyfat at my current musculature level). From the experiences I hear, I would not only struggle to have enough energy to do any kind of rigorous exercise, but struggle to consume the amount of protein I require to even maintain my current muscle mass.

I do have issues with overeating and the prospect of a drug that prevents me from consuming too many calories is attractive, but the side effects sound counterintuitive to any kind of natural fitness.

Re: GLP-1 drugs: An economic disruptor? (2024)

#35

Post by rsync »

luketheobscure wrote: post #23

Is there a term for this style of writing? It's like a longform linkedin post. I don't mean this as a criticism, it just seems like written language is evolving to better capture our diminishing attention spans.

I have been working on a new written form I refer to as an "Iceberg Article":

https://john.kozubik.com/pub/IcebergArticle/tip.html

... which is intended to present detailed, long-form treatments of a subject yet, at the same time, provide something interesting and actionable in a brief moment.

Re: GLP-1 drugs: An economic disruptor? (2024)

#36

Post by saurik »

cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

> Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month...

So they are going to force you onto a higher dose?!

Re: GLP-1 drugs: An economic disruptor? (2024)

#37

Post by devmor »

agnishom wrote: post #33

The author is assuming that everyone will proactively start taking this drug. But I don't understand why? If Jerry is not obese, why would Jerry randomly start taking an anti-obesity drug?

It is a bit of a silly proposition, considering that 40% of Americans are obese, and many of that population cannot afford $800-$2000 prescriptions.

Re: GLP-1 drugs: An economic disruptor? (2024)

#38

Post by Denvercoder9 »

brokensegue wrote: post #26
aljgz wrote: post #14

> When companies like Google see their healthcare costs drop by $12,000 per employee annually and productivity increase by 25%, we observe a restructuring of corporate America that makes remote work a minor adjustment. In my entire office, there's one overweight person that I know. Out of thousands of employees. There could be more, and other cities might be different, but you get the idea. The author intentionally o…

40% of Americans are obese and way more are merely overweight. Either your office is small, a huge fluke, weirdly selected or you're not observant enough.

Or not in the US.

Re: GLP-1 drugs: An economic disruptor? (2024)

#39

Post by willis936 »

cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

Yes well your PCP / pharmacist should not have prescribed you an appetite suppressant when you have below average body fat %. The effects are very worth it for people weighing them against heart disease and mobility issues. It's not a Faustian bargain, it's all right on the tin. When you stop taking it the effects go away. If you want to be indulgent and it fits your lifestyle you can reversibly make that decision. The power to make that decision is difficult to overstate.

Re: GLP-1 drugs: An economic disruptor? (2024)

#40

Post by [deleted] »

rsync wrote: post #28

The real trend is deflation. People are having fewer children. Fewer miles are driven to fewer offices for fewer trips in cars. Fewer impulse buys are being made and fewer dollars will be made by advertisements (according to the ops conjecture). This is not inflationary. It is the opposite. We live in a deeply deflationary world and we should not be confused by the local, transitory inflation that we may be experienc…

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