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Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

nbcnews.com

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Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#31

Post by nordsieck »

Someone1234 wrote: post #7
benchtobedside wrote: post #2

TL;DR from the article: The study found that patients prescribed semaglutide had a significantly lower risk for Alzheimer’s disease than those who had taken one of the seven other diabetes drugs. The results were consistent across gender, age and weight. The biggest difference was seen when comparing patients who took semaglutide to those who took insulin: Semaglutide patients had a 70% lower risk of Alzheimer’s, the…

With the constant stream of positive news around GLP-1s, and ever-growing list of things they treat, we may all wind up on some dose with only the dose varying depending on what illness they're targeting.

> With the constant stream of positive news around GLP-1s, and ever-growing list of things they treat, we may all wind up on some dose with only the dose varying depending on what illness they're targeting.

So far, I haven't seen much evidence that GLP-1s have a positive effect on people who aren't overweight. And while I'll be the first to admit that the proportion of people who could benefit from these drugs is quite large, it's pretty far from everyone.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#32

Post by cthalupa »

mbostleman wrote: post #22
voidfunc wrote: post #19

Earlier quoted context omitted.

Gonna be fun discovering what side effects it causes in 20 years tho.

Exactly. I see all these breathless claims of new uses and how wonderful this drug is and wonder when the other shoe is going to drop.

I’ll make my usual response: we know that being obese is basically the worst possible thing you can do to yourself, and the longer you are, the worse it is. The side effects are going to be pretty awful just to negate that, much less all the other things they seem to be good for.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#33

Post by spondylosaurus »

voidfunc wrote: post #19
thepasswordis wrote: post #18

Of all things my taxes go to, I would love it the United States Government would buy the patent for this drug and make it freely available to anybody who wants it. The number of things it apparently just cures is staggering.

Gonna be fun discovering what side effects it causes in 20 years tho.

Liraglutide, the predecessor to semaglutide, has been on the market for 15 years :)

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#34

Post by rsync »

loeg wrote: post #30
thepasswordis wrote: post #18

Of all things my taxes go to, I would love it the United States Government would buy the patent for this drug and make it freely available to anybody who wants it. The number of things it apparently just cures is staggering.

Novo Nordisk's market cap is $500 B, mostly on the basis of GLP-1 drug profits, and the US' entire discretionary budget is $1,700 B. Even if Denmark would allow the sale, and even if somehow the US did not need to pay a premium to shareholders (typical in acquisitions), that would still be a very substantial expenditure.

The correct unit of measurement here is Iraq wars.

Purchasing NN Would cost roughly 0.2 Iraq wars.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#36

Post by throwaway041207 »

thepasswordis wrote: post #18

Of all things my taxes go to, I would love it the United States Government would buy the patent for this drug and make it freely available to anybody who wants it. The number of things it apparently just cures is staggering.

I have been on compounded GLP-1 for a month, prior to this I was a highly functional alcoholic, basically starting drinking after work every night and going until I passed out. I've drunk well over 50 beers (probably more) a week for the last 20 years. I have not had a drink since going on it.

I have been reading obsessively about this drug since going on it. I have been fortunate enough not to suffer side effects on it, save for one -- frustration with the cynicism around it. A cynicism I shared prior to experiencing its effects.

I am convinced that, barring any life threatening long term side effects, this is the most important drug of our lifetime (from a first world perspective) or until a silver bullet cancer drug is found. The potential to be the tide that lifts so many boats and alleviates so much physical and emotional pain and suffering on a population level is almost overwhelming to think about.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#38

Post by newfocogi »

For the group, because I can never keep the terms straight:

Semaglutide is one specific drug within the class of GLP-1 agonists. Other examples include Liraglutide (Victoza, Saxenda), Dulaglutide (Trulicity), and Tirzepatide (Mounjaro, though this is technically a dual GIP/GLP-1 agonist).

Semaglutide is available under several brand names for different uses: Ozempic (type 2 diabetes), Wegovy (weight management), and Rybelsus (oral form for type 2 diabetes).

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#40

Post by EliRivers »

myprotegeai wrote: post #29
thepasswordis wrote: post #18

Of all things my taxes go to, I would love it the United States Government would buy the patent for this drug and make it freely available to anybody who wants it. The number of things it apparently just cures is staggering.

Yeah, what could go wrong with screwing with the neurochemical reward system of the entire population. Surely that will have no unintended side effects. It's literally a free lunch!

what could go wrong with screwing with the neurochemical reward system of the entire population

We already know what can go wrong.

We already did that decades and decades ago. Sugar, for example. Aside from so many foods being laced with it, you can now simply walk into a store and buy a kilogram of sugar and eat it. So many other examples. That ship sailed a long long time ago. All we can do now is nudge the dial the other way.

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