Non-paywalled: https://archive.ph/20240810233702/https://www.thetimes.com/u...
It took my savings and 14 years but I’m about to beat arthritis
31–40 of 185 posts
Re: It took my savings and 14 years but I’m about to beat arthritis
#32Paywalled. How legitimate is this? As a young sufferer
Re: It took my savings and 14 years but I’m about to beat arthritis
#33> The drug is based on a molecule he discovered while working at Pfizer, and can be delivered via a once-a-month EpiPen-style injection, where it restores protective processes to diseased joints and enables the regeneration of affected tissues. It works by blocking a compound that supports the nerve cells involved in transmitting pain signals to the brain.
So, it restores lost tissue by numbing nerves? This makes no sense.
Wonder if it's just poor reporting or if there is something to this?
Re: It took my savings and 14 years but I’m about to beat arthritis
#34> The drug is based on a molecule he discovered while working at Pfizer, and can be delivered via a once-a-month EpiPen-style injection, where it restores protective processes to diseased joints and enables the regeneration of affected tissues. It works by blocking a compound that supports the nerve cells involved in transmitting pain signals to the brain. So, it restores lost tissue by numbing nerves? This makes no…
I'm thinking the nerves were negative feedback for the regeneration pathways.
Re: It took my savings and 14 years but I’m about to beat arthritis
#35The title is misleading. It's not a "cure for Arthritis"; it's a pain killer.
"it restores protective processes to diseased joints and enables the regeneration of affected tissues. It works by blocking a compound that supports the nerve cells involved in transmitting pain signals to the brain." Yes, I guess you could belittle that by calling it 'a painkiller'. No different at all to taking a handful of ibuprofen, which every arthritis sufferer knows enables regeneration and why it is a solved…
It's one thing to read an article one believes is wrong.
It's another thing to read, as we have here, a title that proclaims 'This is a Pipe' to an article that states 'This is not a pipe'
If it weren't a similar story with so many 'medical breakthrough' headlines, it would annoy less.
Re: It took my savings and 14 years but I’m about to beat arthritis
#36> It is hoped the drug — which is not a cure but will make the condition much less painful for sufferers > It works by blocking a compound that supports the nerve cells involved in transmitting pain signals to the brain. Unfortunately it doesn't fix the underlying issue.
but the sentence prior says "it restores protective processes to diseased joints and enables the regeneration of affected tissues." I don't understand how it does if it's just blocking pain signals.
I don’t know about this case, but in general, the body’s reaction to pain sometimes makes things worse, so relieving pain can be part of encouraging recovery.
Re: It took my savings and 14 years but I’m about to beat arthritis
#37where it says he took all his savings and "beat arthritis": it doesn't appear he has arthritis, he's an entrepreneur who took all his savings and founded a drug startup company with an idea he had around the time Pfizer laid him off
Re: It took my savings and 14 years but I’m about to beat arthritis
#38The title is misleading. It's not a "cure for Arthritis"; it's a pain killer.
Not quite. > The drug is based on a molecule he discovered while working at Pfizer, and can be delivered via a once-a-month EpiPen-style injection, where it restores protective processes to diseased joints and enables the regeneration of affected tissues. It works by blocking a compound that supports the nerve cells involved in transmitting pain signals to the brain. The mechanism might be to affect the nerve cells i…
As a youngish sufferer of osteoarthritis in my foot I had my hopes up, however there is no mention of cartilage or bone in the article.
The “cure” for osteoarthritis would need to regenerate or replace damaged or missing cartilage, a seemingly impossible task from my limited understanding.
Re: It took my savings and 14 years but I’m about to beat arthritis
#39My only commentary would be that these results do not read like clinical success, but rather something suggesting they should move on to phase III clinical trials. This is the only publication I found in a quick search: https://pubmed.ncbi.nlm.nih.gov/37976118/ >> Abstract Objectives: Nerve growth factor β (β-NGF) is a protein which is important to the development of neurons particularly those involved in the transmi…
This is the Phase II clinic study: https://clinicaltrials.gov/study/NCT05618782
They haven't posted the results yet. They have posted a press release saying the results were positive and that they will post the results in a peer reviewed journal. https://levicept.com/wp-content/uploads/2024/08/Levicept-Cli...
Re: It took my savings and 14 years but I’m about to beat arthritis
#40> The drug is based on a molecule he discovered while working at Pfizer, and can be delivered via a once-a-month EpiPen-style injection, where it restores protective processes to diseased joints and enables the regeneration of affected tissues. It works by blocking a compound that supports the nerve cells involved in transmitting pain signals to the brain. So, it restores lost tissue by numbing nerves? This makes no…
It just takes away the pain, it’s clearly written in the article.