90% of House MD plots ruined
To be fair, House's plots usually reiterated, "It's never Lupus."
(And the one time it actually was had a rather disappointing reveal, IMO)
Scientists discover a cause of lupus, possible way to reverse it
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Re: Scientists discover a cause of lupus, possible way to reverse it
#32My girlfriend has lupus, so I showed her the article. It sparked a bit of hope. She has a science background and always asks in awe "how do you find such good papers on the day they get released". She's not really the HN audience though :*)
Re: Scientists discover a cause of lupus, possible way to reverse it
#33Re: Scientists discover a cause of lupus, possible way to reverse it
#3490% of House MD plots ruined
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Re: Scientists discover a cause of lupus, possible way to reverse it
#35My girlfriend has lupus, so I showed her the article. It sparked a bit of hope. She has a science background and always asks in awe "how do you find such good papers on the day they get released". She's not really the HN audience though :*)
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Re: Scientists discover a cause of lupus, possible way to reverse it
#36Autoimmune diseases, of which lupus is but one of many, are essentially black boxes. It’s proven extraordinarily difficult to develop therapies in this area. As such, this is great news. Hopefully this research will encourage pharmaceutical and biotech companies to invest more resources into translating research findings into effective therapies. I haven’t read the paper yet, so I can’t comment on how this discovery…
The aryl hydrocarbon receptor (AhR), which is key to this discovery, appears to be super relevant to psoriasis, another autoimmune disease. AhR has been known for a long time, but it seems it's been somewhat mysterious until a series of recent breakthroughs. In 2022, an AhR inhibitor called tapinarof, sold as VTAMA, was launched, and has shown itself to be one of the most effective treatments for psoriasis to date. I…
Good post. One small correction: Tapinarof isn't an AhR inhibitor, it's an AhR activator, an agonist.
Interestingly, tapinarof is a natural product -- a sort of bacterially-modified stilbene, a chemical cousin of resveratrol and pterostilbene -- and several other natural products also activate AhR. (Though perhaps not exactly in the same way.) The most potent and readily available of these is probably 3,3'-diindolylmethane.
Re: Scientists discover a cause of lupus, possible way to reverse it
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Re: Scientists discover a cause of lupus, possible way to reverse it
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Re: Scientists discover a cause of lupus, possible way to reverse it
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Re: Scientists discover a cause of lupus, possible way to reverse it
#40On one side we have in this article : " insufficient activation of a pathway controlled by the aryl hydrocarbon receptor (AHR), which regulates cells’ response to environmental pollutants, bacteria or metabolites. Insufficient activation of AHR results in too many disease-promoting immune cells, called the T peripheral helper cells, that promote the production of disease-causing autoantibodies. To show this discovery…
Both reactions make sense to me. Too much AHR activation suppresses immune response leading to cancer proliferation due immune cells not culling cancerous cells, but too little leads to auto-immune conditions. It's definitely like a large sloppy code base with lots of implicit overlaps and global effects.
seems to be saying just that :
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140757/
"Autoimmunity and cancer as two sides of the same coin. The figure depicts how tuning of immune system regulatory mechanisms can contribute to autoimmunity, health, or cancer development."
One can wonder if induction of some autoimmune condition may be used as a treatment of some cancers.