is it safe to assume,
that this ffect is rue for taladafil/sindemafil based pills?
Men on Viagra may reduce their Alzheimer's risk – study
31–40 of 67 posts
Re: Men on Viagra may reduce their Alzheimer's risk – study
#32Earlier quoted context omitted.
Yes, sex is just awesome in every sense. Regular sex lowers the level of stress in the body and increases the level of oxytocin. As a result, people feel more motivated to work and experience greater satisfaction from their work as soon as the stress level decreases. It also leads to increased life expectancy, so people have more time to work and more time to have sex - it's a complete cycle
> people feel more motivated to work and experience greater satisfaction from their work It kinda weirded me out to see work/productivity being listed in regards to benefits of sex. Yeah, it might help but this way of thinking sounds absolutely horrendous.
What way of thinking?
OP listed some untypical benefits that come with sex - I think we are all aware of the typical benefits. He/she didn't say "these are the reasons you should have sex"
Re: Men on Viagra may reduce their Alzheimer's risk – study
#33Maybe the brain get's worse at clearing stuff out as your blood vessels age and viagra is opening them up? Cardio, weight lifting, HIIT, sauna, healthy balanced diet, yoga, inversions, beetroot juice, citrulline malate, etc. could all be worthy of investigation ;-)
I wonder if flushing nicotinic acid would work to increase blood vessel function in old age?
Re: Men on Viagra may reduce their Alzheimer's risk – study
#34is it safe to assume, that this ffect is rue for taladafil/sindemafil based pills?
A study for tadalafil or sildenafil would probably show the same effects. Not because of common mechanism that prevents Alzheimer, but because such studies would probably plagued by the same methodological problems.
Re: Men on Viagra may reduce their Alzheimer's risk – study
#35Please let's make a downvote free thread for throwing jokes a round on this topic. We need this freedom for such a topic trending on HN. There is so much low hanging fruit and we're all thinking of several I suspect. My initial thought was in the lane of 'drug is affecting one more head than intended', but it's missing some refinement I'll admit
No, let's not. We don't "need this freedom". And we're not "all thinking of several". Grow up.
I think telling them to grow up is a bit harsh, but yes a thread filled with jokes would not belong on HN imo.
Re: Men on Viagra may reduce their Alzheimer's risk – study
#36Please let's make a downvote free thread for throwing jokes a round on this topic. We need this freedom for such a topic trending on HN. There is so much low hanging fruit and we're all thinking of several I suspect. My initial thought was in the lane of 'drug is affecting one more head than intended', but it's missing some refinement I'll admit
Men on Viagra may reduce their Alzheimer's risk - study … in mice.
Re: Men on Viagra may reduce their Alzheimer's risk – study
#37It's a vasodilator, which is means it also reduces blood pressure (that was the drug's original purpose).
So it's conceivable that it could clear a wider exit pathway for amyloid plaques and other garbage that accumulates in the brain.
It's also why a significant fraction of men who take it develop headaches so painful that sex is the last thing on their mind. Welcome to vasodilators.
Oh and if you already take nitroglycerin for cardiac angina, you can't take viagra because you get twice the headache -- right before you pass out because your blood pressure crashed.
Re: Men on Viagra may reduce their Alzheimer's risk – study
#38Earlier quoted context omitted.
All in all, it's not too surprising. The paper mentions neuroprotective effects, but it has been known for a while that nearly all types of PDE inhibitor can boost cognitive function, which has led to some interest in them as nootropics: https://pubmed.ncbi.nlm.nih.gov/25464010/ There has been some interest in PDE5 inhibitors, specifically, as treatments for Alzheimer's: https://www.sciencedirect.com/science/article/…
Can women take viagra too? For the same cognitive effect?
Yes. It's also used in neonates, both male and female, for its ability to treat pulmonary hypertension -- but also, it is now emerging, for its neuroprotective properties: https://www.frontiersin.org/articles/10.3389/fncel.2022.8796...
From the same paper, there's some indication that its cognitive effects might be more potent in women, as "[s]everal studies have suggested that sex hormones may influence the effects of sildenafil on the brain. Female mice performed significantly better than males after sildenafil treatment following HI insult, which suggests a sex-dependent effect of sildenafil (Engels et al., 2017). The underlying mechanism might be related to the relationship between sex hormones and the NO/cGMP pathway."
Re: Men on Viagra may reduce their Alzheimer's risk – study
#39Or these men simply lead more active lives with regular exercise. Hard to tell.
The study is a bit more sophisticated than that.
Re: Men on Viagra may reduce their Alzheimer's risk – study
#40The study is called "Phosphodiesterase Type 5 Inhibitors in Men With Erectile Dysfunction and the Risk of Alzheimer Disease" and published in "Neurology", for reference. It's open access, link: https://doi.org/10.1212/WNL.0000000000209131
All in all, it's not too surprising. The paper mentions neuroprotective effects, but it has been known for a while that nearly all types of PDE inhibitor can boost cognitive function, which has led to some interest in them as nootropics: https://pubmed.ncbi.nlm.nih.gov/25464010/ There has been some interest in PDE5 inhibitors, specifically, as treatments for Alzheimer's: https://www.sciencedirect.com/science/article/…
I also recommend to check the /r/nootropics subreddit threads [1] on the topic.
[1] https://www.reddit.com/r/Nootropics/search?q=Phosphodiestera...