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FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

investor.lilly.com

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Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#31

Post by nwienert »

nexus7556 wrote: post #9
aantix wrote: post #6

Earlier quoted context omitted.

N=1 I've lost 60+lbs with Mounjaro and never experienced any of the side effects listed. I lost cravings for alcohol, sugars. I was tired once jumping from 2.5->5, but we also have four kids, so.. These are my most recent blood work numbers. My A1C was 4.7 https://imgur.com/a/Wwwbhon

+1 I'm at 55 lbs lost since July 1. No side effects at all.

Lost 35 (I didn't start too high so this was all I needed), and actually side effects almost entirely positive. Stopped all smoking, better quality sleep, less immune system issues.

Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#32

Post by lotsofpulp »

chimeracoder wrote: post #26
lotsofpulp wrote: post #21

Earlier quoted context omitted.

> they suddenly discover that the old formulation has serious side effects that make it too dangerous to keep making. Who is they? > And oh, by the way, we also happen to be introducing a very very very slightly different molecule that qualifies for a brand new patent Presuming “we” is the companies that own the current patent, what does this have to do with the older molecule’s patent that is expiring?

> Presuming “we” is the companies that own the current patent, what does this have to do with the older molecule’s patent that is expiring? "Evergreening" is a very common practice among pharmaceutical companies. In its purest form, it looks like this: * About 10 years after a drug has been approved, they will seek approval for a replacement version which is very similar, but different enough to qualify for a differe…

>* About 10 years after a drug has been approved, they will seek approval for a replacement version which is very similar, but different enough to qualify for a different patent.

Why are other companies not jumping on this opportunity before 10 years?

>Then, when the patent for the first drug expires (year 17), there's "no market" for it, because nobody is currently prescribed that drug, so no manufacturers will bother producing any generic versions of it.

So the cost of educating consumers (marketing) is not offset by the difference in cost of selling the generic and the cost of selling the new patented version?

Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#33

Post by standardUser »

DrBenCarson wrote: post #2

Can't wait for the day semaglutide and tirzepatide are available as generics

I have illegally ordered generic pharmaceuticals from overseas and I will do it again. Sometimes the right answer to unreasonable market constraints is simply the black market. See also: recreational drugs, sex

Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#34

Post by qwertox »

belltaco wrote: post #23
candiddevmike wrote: post #19

Earlier quoted context omitted.

What are the side effects? There's never a free lunch with biological systems...

Free lunches are part of the problem that led us here in the first place.

It was sugar.

Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#35

Post by gen220 »

Has anybody here taken this category of drug, lost significant weight, and kept it off after dropping the drug?

I've seen great success stories, but I'm kind of nervous of the long-term effects of taking a drug like this for your whole lifetime (i.e. what's implied by the "chronic" in "chronic weight management").

It seems like it might be a great off-ramp from obesity to a body weight where the risk of injury in exercise is greatly diminished and the degree of enjoyment in exercise goes way up. If you could go off the drug and then use exercise to maintain the caloric deficit (instead of under-eating, as the drug induces you to do), that sounds like it would be kind of miraculous.

Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#36

Post by molsongolden »

With these drugs, is there any mechanism at work beyond "patients have a lower appetite and eat less food"?

I've only read a few papers and articles but what I've seen is that all of the hormone triggering leads to 1) decreased appetite 2) slowed gastric emptying which also decreases appetite.

Patients lose weight due to eating less but usually regain the weight when stopping the drug since they then go back to their normal level of eating.

---

Are these drugs fixing/replacing a system failure where people don't feel satiated normally?

Can the same effect be replicated by eating a higher fiber and higher fat diet with more whole foods to feel full longer and slow gastric emptying?

Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#37

Post by rs_rs_rs_rs_rs »

nathanyz wrote: post #16
xnx wrote: post #12

This is definitely a historic moment in US public health. Today we look at photos and marvel at how prevalent smoking was 50 years ago (in restaurants, in hospitals, in airplanes, etc.). 40 years from now people will look at photos from the last decade and be in disbelief at how widespread obesity was.

This cannot be understated. Obesity is being changed from a willpower problem to a chronic disease that is treatable. The follow-on effects of this are huge.

>Obesity is being changed from a willpower problem to a chronic disease that is treatable

It's absolutely a willpower problem. These medications won't fix that for you. You stop taking them and you will gain weight again.

Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#38

Post by Obscurity4340 »

aantix wrote: post #30
Obscurity4340 wrote: post #28

Earlier quoted context omitted.

What is the gold standard currently? Like phentermine or diethylpropion? Or is it actually Ozempic?

Of FDA approved medications for weight loss, tirzepatide would be the current gold standard. https://www.nejm.org/doi/full/10.1056/nejmoa2107519 I think retatrutide might be the current leader for weight loss from clinical trials. If I remember correctly, you lost the same amount of weight on retatrutide vs tirzepatide, but over a shorter time span.

You're saying this NEW medication is already currently the gold standard? What was it prior?

Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#39

Post by n8cpdx »

ng12 wrote: post #17

> Research now shows that the body may respond to a calorie-deficit diet by increasing hunger and reducing feelings of fullness Dieting makes you hungry, truly revolutionary research.

It seems obvious but the “just eat less” crowd needs to hear it.

Ever try working on a tricky coding project while starving? Take a math test when all you can think about is finding something, anything, to eat?

Losing significant amounts of weight the natural way isn’t so much a test of willpower as a test of how well you can function under a constant sense of hunger (or, how good you are at tricking your way out of it).

Bonus tip: when you are so hungry you can’t sleep and don’t want to drink a bunch of water right before bed, sugar-free jell-o has only 10 calories and can silence the feeling long enough to fall asleep.

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