Is it possible that small bugs or assumptions in a root paper could cascade through referencing papers leading to wildly inaccurate outcomes 5 or 6 papers down the line?
In theory yes. In practice mathematicians tend to have a good instinct for which things are true (although not always - some false theorems stood for decades if not centuries) and will avoid looking into ideas that don't pass the sniff test. Plus if you keep building on the consequences of a false result then you'll likely eventually reach a contradiction, which might inspire you to spot the bug in the original resul…
I wonder if they are good, or if it's selection/confirmation/other biases that lead is to think say.
Also, aren't surprising results the most interesting!?