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Time-restricted eating reshapes gene expression throughout the body

sciencedaily.com

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Re: Time-restricted eating reshapes gene expression throughout the body

#31

Post by andy_ppp »

ford wrote: post #25
andy_ppp wrote: post #21

A mouse only lives 5 years so if we scale everything based on this to humans you’d have to be fasting for 16h * (80 years / 5 years) = 256h or nearly 11 days. You could be damn sure doing this regularly your gene expression would change. Of course basing the scaling this way is completely ridiculous but no less ridiculous than inferring anything about humans from the original study.

I see where you're coming from, but just because mice don't live as long as humans doesn't mean all biological processes happen 16x as fast. They don't defecate 16x as often as humans or sleep 16x per day. Do you think there is 0 signal about potential impacts on humans from testing on mice? How would you prefer research be done with a similar cost, ability to control variables, & level of ethics?

I think the extrapolations you’ve made from my comments are fighting an argument I’ve not made and am not interested in having because I’m not a scientist working on these things. What I’ve tried to explain in my comment is that we do not know how the metabolism of a mouse doing 16:8 relates to a human being. No more and no less, we simply do not know how to do that mapping and trying to draw conclusions about humans from this specific study is fairly futile because of this (unless they are using some methodology I’m not aware of)!

Re: Time-restricted eating reshapes gene expression throughout the body

#32

Post by StefanWestfal »

pammf wrote: post #14

I’ve been doing intermittent fasting for 2 years. Did a bunch of different protocols and eventually settled on ~18:6. Lost around 15kgs (from 105 to 90) and as a nice “side effect” got rid of all skin problems that I’d had during the previous 10 years or so. Today I don’t preach it anymore cause I got tired of debating whether it was healthy or not but I definitely recommend to everyone that’s truly interested in giv…

I tried it for some time but felt cranky in the morning until I ate at lunch time. How was your experience regarding cravings, hunger and mood changes over time when starting your fasting?

Re: Time-restricted eating reshapes gene expression throughout the body

#34

Post by kbrisso »

kayoone wrote: post #12
mrandish wrote: post #4

Notes: - In mice. - Tested 16:8 pattern. - Sustained consistently for nine weeks. - No exploration in this study of the effects and/or benefits from the gene expression. N=1 but I've been doing ~16:8-ish along with strict keto for the past five years and the net benefits for me have been transformative in fitness (Weight: -100+ lbs, BMI: Obese->Fit), long-term health (A1C, LDL/HDL, Trigs, BP, resting heart rate all f…

I had similar improvements without fasting and without keto. I do 16:8 on some days but it's mostly to help me manage my weight. I strongly believe most of the fasting benefits come from the fact that it makes managing weight easier. Calorie restriction and tracking my macros has helped me tremendously not only loosing weight but also understanding nutrition and what works for me and what doesn't. I am a 40 year old…

You need to stay on it for months to become keto adapted. I would say 6 months minimum, after that the energy swings go away and you generally have a lot more energy. You can also add MCT oil. The problem with keto is eating enough calories.

Re: Time-restricted eating reshapes gene expression throughout the body

#35

Post by TedDoesntTalk »

snozolli wrote: post #28
sometimesno wrote: post #11

Earlier quoted context omitted.

16:8 is utterly unremarkable. A huge percent of people skip breakfast and then have dinner before 8pm. This is a normal, bog standard eating pattern.

In my experience, it's exceptional in America. This may be due to constant indoctrination that "breakfast is the most important meal of the day". Also, modern food processing has put all sorts of late-night snacks at our fingertips.

Agreed. 16:8 is not normal in America in 2023. Most people pay absolutely no attention to when they eat - only what they eat.

Re: Time-restricted eating reshapes gene expression throughout the body

#36

Post by manmal »

mrandish wrote: post #4

Notes: - In mice. - Tested 16:8 pattern. - Sustained consistently for nine weeks. - No exploration in this study of the effects and/or benefits from the gene expression. N=1 but I've been doing ~16:8-ish along with strict keto for the past five years and the net benefits for me have been transformative in fitness (Weight: -100+ lbs, BMI: Obese->Fit), long-term health (A1C, LDL/HDL, Trigs, BP, resting heart rate all f…

To give another N=1, I don’t feel good on a 16:8 split. At least not when the eating window starts at noon. Long term (18 months) this zapped my energy and I lost a lot of muscle. Yes, weight loss was phenomenal, but I gained all of that back in the phase of exhaustion that followed.

What has worked better for me was longer fasts, eg 48h, max once per week. And lately I‘ve been experimenting with skipping late dinner (no food after 6PM) which is kinda hard but seems to work for improved sleep and digestive health. I usually have visible bags under my eyes, those tend to be greatly reduced when I eat an early or no dinner.

Re: Time-restricted eating reshapes gene expression throughout the body

#37

Post by piqi »

snozolli wrote: post #28
sometimesno wrote: post #11

Earlier quoted context omitted.

16:8 is utterly unremarkable. A huge percent of people skip breakfast and then have dinner before 8pm. This is a normal, bog standard eating pattern.

In my experience, it's exceptional in America. This may be due to constant indoctrination that "breakfast is the most important meal of the day". Also, modern food processing has put all sorts of late-night snacks at our fingertips.

Hard to imagine skipping breakfast, lunch, coffee/tea w/milk & cream, and all snacking during the day, everyday is normal outside America. Isn't burned bread with beans or butter for breakfast a thing in the UK?

16:8 means if your last calories are before 10PM, you wouldn't eat anything at all until after 2 PM. And this would be every day, not every other day.

12:12 might be more common, but not consistently.

Re: Time-restricted eating reshapes gene expression throughout the body

#38

Post by TedDoesntTalk »

yonibot wrote: post #5
mrandish wrote: post #4

Notes: - In mice. - Tested 16:8 pattern. - Sustained consistently for nine weeks. - No exploration in this study of the effects and/or benefits from the gene expression. N=1 but I've been doing ~16:8-ish along with strict keto for the past five years and the net benefits for me have been transformative in fitness (Weight: -100+ lbs, BMI: Obese->Fit), long-term health (A1C, LDL/HDL, Trigs, BP, resting heart rate all f…

N=1 and also probably too many variables to learn from this - keto itself is already a massive lifestyle intervention. Did you restrict calories as well? Exercise?

most everyone sees body changes when using time-restricted eating WITHOUT any dietary changes. There’s no need to go keto like OP to see results.

Re: Time-restricted eating reshapes gene expression throughout the body

#39

Post by cycomanic »

mhaberl wrote: post #17
sidcool wrote: post #10

Does restricted time eating mean intermittent fasting?

yes, but only for a short time, usually 16-20h long fasts. Some people do fasts that last for multiple days, usually 3-7 days - this not I.F.

I have seen IF described as both in a day and in a week. Supposedly the effects are very similar as well.

Re: Time-restricted eating reshapes gene expression throughout the body

#40

Post by gavinray »

StefanWestfal wrote: post #32
pammf wrote: post #14

I’ve been doing intermittent fasting for 2 years. Did a bunch of different protocols and eventually settled on ~18:6. Lost around 15kgs (from 105 to 90) and as a nice “side effect” got rid of all skin problems that I’d had during the previous 10 years or so. Today I don’t preach it anymore cause I got tired of debating whether it was healthy or not but I definitely recommend to everyone that’s truly interested in giv…

I tried it for some time but felt cranky in the morning until I ate at lunch time. How was your experience regarding cravings, hunger and mood changes over time when starting your fasting?

Not the poster but the hunger lessens after the first few weeks as you adapt to it, or at least that's my experience

I start to dread eating a bit now because I get tired/sleepy after I do. I want to eat because I'm hungry but mentally feel clearer if I don't.

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