Question for people up to date with modern biochemistry: if there were extraterrestrial microbes on Earth right now, with totally unique chemical origins unrelated to proteins, nucleic acids, saccharides, etc., how likely would we be to notice them? And which analytic method would find them first? Is there a systemic search for this kind of crazy stuff, and where are the review papers for them? I don't know the keywo…
Very, very unlikely like astronomically so. Most microorganisms are so small they're practically transparent so we have to exploit biochemistry to "stain" them - hence why you'll often hear of bacteria classified as either Gram positive or negative, because of the Gram stain. If the biochemistry is unique or even slightly different i.e. right handed chirality, we'd basically have zero of our usual tools at our dispos…
I'm going to bookmark this for the case someone asks: what piece of information that seems basic did you ignore until very recently?
A question that often arises is: if current life evolved from chemistry that's simpler than DNA, why has that one disappeared? Maybe it hasn't.