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Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

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Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#31

Post by orangepurple »

JumpCrisscross wrote: post #28
orangepurple wrote: post #4

The bigger story with rapamycin is that the mechanistic target of rapamycin (mTOR) plays an absolutely crucial role in major diseases of modern civilization. One of the ways to inhibit mTOR for free is to simply stop consuming nutrients for extended periods of time.

> ways to inhibit mTOR for free to simply stop consuming nutrients for extended periods of time How frequently and for how long must one fast to see this?

As long as you can bear it. Which for me has been 24 +/- 4 hours between meals for 9 months and counting.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#32

Post by orangepurple »

chrisweekly wrote: post #7
Tepix wrote: post #6

Earlier quoted context omitted.

> ... to simply stop consuming nutrients for extended periods of time That is not simple for most people.

simple != easy

Agree; it was very painful initially and not easy. But very simple conceptually!

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#33

Post by orangepurple »

nik_s wrote: post #30
nils-m-holm wrote: post #11

Earlier quoted context omitted.

> One of the ways to inhibit mTOR for free to simply stop consuming nutrients for extended periods of time. What is an extended period of time in this context? I happen to consume all my meals within seven hours every day and only drink water in between. Would that help? (Not doing this for health reasons, it is just a habit.)

This [1] study was pretty thorough on different fasting lengths. They tested 1422 patients for fasting lengths between 4 and 21 days, with a maximum calorie consumption of 200-250kcal and a moderate-intensity lifestyle program. It concludes that all fasting lengths are beneficial, and are likely going to result in a) reduction in weight and waist circumference, b) beneficial effects on blood lipids, regulation of sug…

To build on this post it is further beneficial to understand the importance of the interaction between clock genes and nutrient intake timing for optimal results

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#34

Post by jtbayly »

forgotmypw17 wrote: post #14
nils-m-holm wrote: post #11

Earlier quoted context omitted.

> One of the ways to inhibit mTOR for free to simply stop consuming nutrients for extended periods of time. What is an extended period of time in this context? I happen to consume all my meals within seven hours every day and only drink water in between. Would that help? (Not doing this for health reasons, it is just a habit.)

A good measure is whether or not you feel that empty, churning feeling in your stomach. Another good measure is if you're into the idea of eating something like plain cabbage or oats.

I feel that after a few hours of not eating. Is feeling it or not feeling it the sign that I've reached the necessary effect?

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#35

Post by aaaaaaaaaaab »

orangepurple wrote: post #31
JumpCrisscross wrote: post #28

Earlier quoted context omitted.

> ways to inhibit mTOR for free to simply stop consuming nutrients for extended periods of time How frequently and for how long must one fast to see this?

As long as you can bear it. Which for me has been 24 +/- 4 hours between meals for 9 months and counting.

And what conditions did you cure with this regime?

Did your overall calorie intake remain the same?

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#36

Post by orangepurple »

meremortals wrote: post #12

How does one find a doctor willing to prescribe these kinds of drugs for anti aging?

The easiest way by safely and strongly inhibit mTOR is to simply stop eating for a while. Most people don't need the drug.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#37

Post by noneeeed »

lbotos wrote: post #22
telesilla wrote: post #17

The article states effectiveness requires taking the drug as a young adult, precisely the time most people are not thinking about mortality.

I’d beg to differ. In the modern social media age youths are getting a lot more vain. Teen boys are doing skincare routines. So historically, I’d agree, but now that everyone can be a minor celeb in their own circle I think the youth are more focused on aging.

> Teen boys are doing skincare routines.

For context, there have been other periods in history when young men were as focused on their apperance as women, used makeup and obsessed about how they were seen.

Social media gives an outlet for this to those who are not wealthy, but none of it is fundamentally new, it was just confined to those who were able to do it.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#38

Post by orangepurple »

boredemployee wrote: post #19

genuine question: why would someone want to live longer than the average? Edit: I ask because I personally don't see a reason to stay alive while people I love are dying, I don't see a reason to stay alive in an already fucked up planet, while we empty all the resources, etc. But you guys are so smart, intelligent and clever, why even bother.

It's generally not maximizing lifespan people are interested in but rather maximizing health span which is the period of time you are healthy and able to operate at a high level. If done correctly you die with minimum time spent disabled.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#40

Post by ilaksh »

The idea that you could just take a pill one time and be "protected from aging" or something sounds ludicrous. Would be interested to see people reproduce these results and have them supposedly transfer over to humans. Humans are a much longer time scale.

I always go back to the SENS concept of having several different problems to solve related to built up damage, cells that won't die, etc.

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