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A lab pursuing de-extinction of the thylacine partners with a genetics company

unimelb.edu.au

31–40 of 60 posts

Re: A lab pursuing de-extinction of the thylacine partners with a genetics company

#31

I wonder, have they asked the people of Tasmania if they want it back? It's Jurassic Park writ small.

This is different since they were exterminated by humans, not by natural processes. It could be argued we have the moral obligation to bring them back if able.

Re: A lab pursuing de-extinction of the thylacine partners with a genetics company

#32
post #2

It’s amazing what an incredibly prescient work of science fiction Jurassic Park (the novel) really was. Before CRISPR, before Dolly, before the Human Genome, Crichton called it.

One can’t help but wonder how much the movie influenced the work

It's an idea that's been around a long time. Even the specific idea of a dinosaur park with cloned dinosaurs is not novel to the novel:

https://en.wikipedia.org/wiki/The_Cursed_Earth_(Judge_Dredd_...

Re: A lab pursuing de-extinction of the thylacine partners with a genetics company

#33
Oh hey! I joined Colossal Biosciences 6 months ago from a post on the Who's Hiring thread and can say it's an incredible place to work, with some of the sharpest people I've ever met in both the biology and computer science space. This is just one of several awesome projects we're working on.

We're actively hiring frontend and backend engineers (React, Golang, GCP/multicloud). Drop a line: darren @ colossal.com

Re: A lab pursuing de-extinction of the thylacine partners with a genetics company

#34
post #23

Earlier quoted context omitted.

It's not plausible that such a large animal can have a self-sustaining population in the wild, and not be properly detected by the scientific community for 100 years.

Twelve animals thought to be extinct, some for hundreds, one for millions of years, before being rediscovered: https://www.treehugger.com/lazarus-species-extinct-animals-f...

Except that in general the "rediscovery" isn't something dramatic -- it's just a systematist in a lab looking at an animal known by many and realizing that it is the same species as fossilized/preserved specimens thought to be extinct rather than a common related species. That's quite different from finding a thylacine, an animal that couldn't be confused with anything else.

Re: A lab pursuing de-extinction of the thylacine partners with a genetics company

#35
post #9

Is this likely to be the first de-extinct animal which we can bring back does anyone know?

The Pyrenean ibex was de-extincted for 7 minutes: https://www.nationalgeographic.com/science/article/news-buca... There are a number of other candidates, though. I would guess either the thylacine, the woolly mammoth, or the passenger pigeon would be first to sustain an actual population, but I don't really follow the projects: https://en.wikipedia.org/wiki/De-extinction#Current_candidat...

Colossal (the company mentioned in the article) is actively working on the mammoth as well --> https://colossal.com/mammoth/

Source: I work there.

Re: A lab pursuing de-extinction of the thylacine partners with a genetics company

#37

“We can now take the giant leaps..." says Professor Pask of the Thylacine Integrated Genetic Restoration Research (TIGRR) Lab. Which is a lot more accurate than the article headline, which says that they _have already_ taken a 'giant leap'. I expect such exaggeration and overstatement from mainstream news sources; I suppose I should not be surprised to see it coming from a university website.

[deleted]

Re: A lab pursuing de-extinction of the thylacine partners with a genetics company

#38

“We can now take the giant leaps..." says Professor Pask of the Thylacine Integrated Genetic Restoration Research (TIGRR) Lab. Which is a lot more accurate than the article headline, which says that they _have already_ taken a 'giant leap'. I expect such exaggeration and overstatement from mainstream news sources; I suppose I should not be surprised to see it coming from a university website.

At least they didn’t say quantum leap…

Re: A lab pursuing de-extinction of the thylacine partners with a genetics company

#39
post #23

Earlier quoted context omitted.

Twelve animals thought to be extinct, some for hundreds, one for millions of years, before being rediscovered: https://www.treehugger.com/lazarus-species-extinct-animals-f...

Except that in general the "rediscovery" isn't something dramatic -- it's just a systematist in a lab looking at an animal known by many and realizing that it is the same species as fossilized/preserved specimens thought to be extinct rather than a common related species. That's quite different from finding a thylacine, an animal that couldn't be confused with anything else.

This seems like a very inaccurate summary of the examples given in that article.

Re: A lab pursuing de-extinction of the thylacine partners with a genetics company

#40

Earlier quoted context omitted.

Why?

My guess: if non-genetic heritable elements -- epigenetics (such as modifications to DNA) -- are necessary for proper development, then the DNA sequence alone will not be enough to develop thylacines. (There are caveats, notably that some modifications can be inferred). However, the scientists will also be experimenting with gestation and creating embryos from modified cells, so whether epigenetics specifically is a…

Yes, that was basically my point. There has also been some fairly fevered speculation about epigenetics being responsible for some types of instinct - even "cross-generational memories" and the like.
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