Interesting work, but this seems like only the first half of the experiment. Would love to see the data when the experiment is completed.
Possible impact of functional active gpcr-autoantibodies in long Covid
31–40 of 53 posts
Re: Possible impact of functional active gpcr-autoantibodies in long Covid
#32Earlier quoted context omitted.
By that definition, anyone experiencing chronic illness symptoms "following" (said another way, "after") a Covid infection has "Long Covid" - even if Covid had nothing to do with those chronic illness symptoms developing or continuing. I think we need a better definition.
I think at this point diagnosing long covid necessarily involves trusting patients. If you had no chronic illness symptoms you were aware of, and then get covid, and then have chronic illness symptoms - that's long covid. Until we understand what it is better, there's not going to be any way to objectively test for it, or define it more clearly.
Or a coincidence.. Not an unlikely one either, given the broad and vague set of symptoms.
Re: Possible impact of functional active gpcr-autoantibodies in long Covid
#33Earlier quoted context omitted.
You can say that one has sore throat, or fever, or fatigue, or headache. But if you say one has long COVID, you are describing a condition (possibly a new illness, but not yet?) with a wide range of symptoms that occur in different combinations in different people, it seems fine to ask for clarification about what sets it apart other than having gone through acute COVID (natural question, as a person who has gone thr…
> reported by people who have had acute COVID. Plenty of cases of long covid are linked to not-particularly-severe covid cases.
Re: Possible impact of functional active gpcr-autoantibodies in long Covid
#34Re: Possible impact of functional active gpcr-autoantibodies in long Covid
#35"GPCRs are the largest superfamily of integral membrane proteins in humans10. GPCRs play an essential role in vertebrate physiology by sensing the external environment of a cell and responding to a variety of physiological stimuli11. For instance, GPCRs coordinate the cellular behavior involved in host immune responses."
" we suspect that the homeostasis of aab relationships, which are possibly a physiological part of our immune system, may break down, causing autoimmune disease."
Re: Possible impact of functional active gpcr-autoantibodies in long Covid
#36The title here ("100% of Long Covid patients have GPCR-autoantibodies") is editorialized, making this sound interesting. The actual title is "Possible Impact of functional active GPCR-autoantibodies on retinal microcirculation in Long-COVID." The study looked at 76 long covid patients with no control group, so you can't make a general conclusion from it. This post is a waste of time unless you're interested in obscur…
Re: Possible impact of functional active gpcr-autoantibodies in long Covid
#37To the people wondering where the control group is; most people don't test positive to GPCR-autoantibodies. I don't know where the threshold is set but the probability that all 76 long-covid patients test positive is otherwise rather low.
Re: Possible impact of functional active gpcr-autoantibodies in long Covid
#38Earlier quoted context omitted.
> reported by people who have had acute COVID. Plenty of cases of long covid are linked to not-particularly-severe covid cases.
Acute doesn't mean severe, it means short. I used it to distinguish from long/chronic.
Re: Possible impact of functional active gpcr-autoantibodies in long Covid
#39Earlier quoted context omitted.
By that definition, anyone experiencing chronic illness symptoms "following" (said another way, "after") a Covid infection has "Long Covid" - even if Covid had nothing to do with those chronic illness symptoms developing or continuing. I think we need a better definition.
I think at this point diagnosing long covid necessarily involves trusting patients. If you had no chronic illness symptoms you were aware of, and then get covid, and then have chronic illness symptoms - that's long covid. Until we understand what it is better, there's not going to be any way to objectively test for it, or define it more clearly.
I have done an asymptomatic COVID, so by all definition, I do suffer of long COVID.
Of course it could also be due to the fact that I am just generally getting older, being more tired and having a bit more headaches. Also, like many people I am doing a bit less sports than I used to, and my alcohol consumption has increased. The economy has gone to shit and my stress level have increased. It's probably unrelated tho and I will assume that the cause of my aliments is COVID.
"Long COVID" was used to describe the leftover symptoms of people suffering from a very hard COVID infection, leaving their lung half destroyed. Even tho they left the ICU, they still weren't back to 100%, and that's perfectly understandable. It could easily be identified by looking at a scan of a patient lungs.
It's now used as a catch-all name for purely subjective and self reported symptoms, which are also caused by bad diet, lack of exercise, excessive stress levels. No amount of scan/x-ray/... can be used to diagnose it, which is extremely convenient.
I do believe that "long COVID" is real. I just don't believe that self-diagnosis is the right way to measure it.
Re: Possible impact of functional active gpcr-autoantibodies in long Covid
#40Earlier quoted context omitted.
Long covid is ongoing chronic illness symptoms following a covid infection, including but not limited to fatigue, heart problem, lung problems, brain fog, and auto-immune problems.
By that definition, anyone experiencing chronic illness symptoms "following" (said another way, "after") a Covid infection has "Long Covid" - even if Covid had nothing to do with those chronic illness symptoms developing or continuing. I think we need a better definition.