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Possible impact of functional active gpcr-autoantibodies in long Covid

iovs.arvojournals.org

31–40 of 53 posts

Re: Possible impact of functional active gpcr-autoantibodies in long Covid

#31
I came here to say "sure. But what's the control group," and "this would be more interesting if 100% of non-long-covid sufferers didn't have the antibody."

Interesting work, but this seems like only the first half of the experiment. Would love to see the data when the experiment is completed.

Re: Possible impact of functional active gpcr-autoantibodies in long Covid

#32

Earlier quoted context omitted.

By that definition, anyone experiencing chronic illness symptoms "following" (said another way, "after") a Covid infection has "Long Covid" - even if Covid had nothing to do with those chronic illness symptoms developing or continuing. I think we need a better definition.

I think at this point diagnosing long covid necessarily involves trusting patients. If you had no chronic illness symptoms you were aware of, and then get covid, and then have chronic illness symptoms - that's long covid. Until we understand what it is better, there's not going to be any way to objectively test for it, or define it more clearly.

> If you had no chronic illness symptoms you were aware of, and then get covid, and then have chronic illness symptoms - that's long covid.

Or a coincidence.. Not an unlikely one either, given the broad and vague set of symptoms.

Re: Possible impact of functional active gpcr-autoantibodies in long Covid

#33

Earlier quoted context omitted.

You can say that one has sore throat, or fever, or fatigue, or headache. But if you say one has long COVID, you are describing a condition (possibly a new illness, but not yet?) with a wide range of symptoms that occur in different combinations in different people, it seems fine to ask for clarification about what sets it apart other than having gone through acute COVID (natural question, as a person who has gone thr…

> reported by people who have had acute COVID. Plenty of cases of long covid are linked to not-particularly-severe covid cases.

Acute doesn't mean severe, it means short. I used it to distinguish from long/chronic.

Re: Possible impact of functional active gpcr-autoantibodies in long Covid

#35
This paper here will fill in the gaps of why auto antibodies against GPCR could be a bad thing - initiating autoimmune disease.

"GPCRs are the largest superfamily of integral membrane proteins in humans10. GPCRs play an essential role in vertebrate physiology by sensing the external environment of a cell and responding to a variety of physiological stimuli11. For instance, GPCRs coordinate the cellular behavior involved in host immune responses."

" we suspect that the homeostasis of aab relationships, which are possibly a physiological part of our immune system, may break down, causing autoimmune disease."

https://www.nature.com/articles/s41467-018-07598-9

Re: Possible impact of functional active gpcr-autoantibodies in long Covid

#36
post #23

The title here ("100% of Long Covid patients have GPCR-autoantibodies") is editorialized, making this sound interesting. The actual title is "Possible Impact of functional active GPCR-autoantibodies on retinal microcirculation in Long-COVID." The study looked at 76 long covid patients with no control group, so you can't make a general conclusion from it. This post is a waste of time unless you're interested in obscur…

I couldn't tell from the abstract (is there a link I missed), but I suspect that the test for GPCR-autoantibodies has a baseline (e.g. to test positive you must be 2-sd above the mean). From that if all 76 test positive you can know without a control group that that is otherwise very unlikely and a strong signal of correlation.

Re: Possible impact of functional active gpcr-autoantibodies in long Covid

#37
I've tested +ve for many GPCR-autoantibodies, I had it done at the CellTrend lab. I've never had covid but my pre-existing ME/CFS was made vastly worse from the booster shot, I have particularly high count of ACE2-AAb which seems to be associated with covid, and or the vaccine. I have the genetic predisposition called hEDS and knew the risks when I took them. It's taken 3 months of many powerful and experimental drugs and I'm just starting to get back to my normal baseline.

To the people wondering where the control group is; most people don't test positive to GPCR-autoantibodies. I don't know where the threshold is set but the probability that all 76 long-covid patients test positive is otherwise rather low.

Re: Possible impact of functional active gpcr-autoantibodies in long Covid

#38

Earlier quoted context omitted.

> reported by people who have had acute COVID. Plenty of cases of long covid are linked to not-particularly-severe covid cases.

Acute doesn't mean severe, it means short. I used it to distinguish from long/chronic.

Oh, interesting. I hadn't actually encountered that definition of acute. Looked it up. Seems like medical dictionaries lean towards defining acute as an opposite to chronic, while non-medical dictionaries include that and other definitions like "extremely sharp or severe; intense" - which is how I took it. Good to know, for talking to doctors.

Re: Possible impact of functional active gpcr-autoantibodies in long Covid

#39

Earlier quoted context omitted.

By that definition, anyone experiencing chronic illness symptoms "following" (said another way, "after") a Covid infection has "Long Covid" - even if Covid had nothing to do with those chronic illness symptoms developing or continuing. I think we need a better definition.

I think at this point diagnosing long covid necessarily involves trusting patients. If you had no chronic illness symptoms you were aware of, and then get covid, and then have chronic illness symptoms - that's long covid. Until we understand what it is better, there's not going to be any way to objectively test for it, or define it more clearly.

After two years of confinement I have exhibited several of the symptoms associated with long covid.

I have done an asymptomatic COVID, so by all definition, I do suffer of long COVID.

Of course it could also be due to the fact that I am just generally getting older, being more tired and having a bit more headaches. Also, like many people I am doing a bit less sports than I used to, and my alcohol consumption has increased. The economy has gone to shit and my stress level have increased. It's probably unrelated tho and I will assume that the cause of my aliments is COVID.

"Long COVID" was used to describe the leftover symptoms of people suffering from a very hard COVID infection, leaving their lung half destroyed. Even tho they left the ICU, they still weren't back to 100%, and that's perfectly understandable. It could easily be identified by looking at a scan of a patient lungs.

It's now used as a catch-all name for purely subjective and self reported symptoms, which are also caused by bad diet, lack of exercise, excessive stress levels. No amount of scan/x-ray/... can be used to diagnose it, which is extremely convenient.

I do believe that "long COVID" is real. I just don't believe that self-diagnosis is the right way to measure it.

Re: Possible impact of functional active gpcr-autoantibodies in long Covid

#40

Earlier quoted context omitted.

Long covid is ongoing chronic illness symptoms following a covid infection, including but not limited to fatigue, heart problem, lung problems, brain fog, and auto-immune problems.

By that definition, anyone experiencing chronic illness symptoms "following" (said another way, "after") a Covid infection has "Long Covid" - even if Covid had nothing to do with those chronic illness symptoms developing or continuing. I think we need a better definition.

I personally share your skepticism of self-reported diagnoses for such a vaguely defined condition. But it seems to me that a key part of developing a better definition would be to perform investigations like those in the source article, studying people with self-reported Long Covid to identify similarities between people who report it and/or differences with those who don't. How else could you research something like this?
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