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In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

nature.com

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Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#31

Post by celim307 »

throwaway742 wrote: post #28

Am I the only one who thinks immortality is a nightmare? I don't understand people who want to live forever.

If my quality of life remains high and I can still choose to end things when I want, I don’t see an issue. Then again there’s probably psychological cost and I may end up a sociopath

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#32

Post by bowsamic »

throwaway742 wrote: post #28

Am I the only one who thinks immortality is a nightmare? I don't understand people who want to live forever.

HN is the only place where I’ve seen people purpose immortality as a legit goal. I think it’s because of lack of religion. If you are existentially scared of death and you are a techie, it makes sense

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#33

Post by bredren »

jeppebemad wrote: post #25
davidedicillo wrote: post #14

For anyone interested in the topic, I'd encourage reading "Lifespan" by David A. Sinclair. As someone with little to no-knowledge about aging (other than feeling the effects of aging on myself) I found it very instructive on how our aging clock works and what are some of the ongoing studies to slow down or revert aging.

I can the recommend recent interview with him on the The Knowledge Project podcast. Had a lot of aha-moments listening to that.

Thanks for the tip.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#35

Post by desertraven »

throwaway742 wrote: post #28

Am I the only one who thinks immortality is a nightmare? I don't understand people who want to live forever.

I tend to agree with you. In saying that, I wouldn't mind an extra 100 years. If we could invent a mechanism to avoid concentrated power/resources [1], I think humanity would be better off; for if we can mostly agree that "with age comes wisdom", we would surely be collectively wiser.

[1] - The mechanism to avoid concentrated power is a drop in for many other things. For example, I believe if societal structures could effectively optimise for ethical behaviour, individuals would be less likely to crave for power lust and greed.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#36

Post by veltas »

bowsamic wrote: post #32
throwaway742 wrote: post #28

Am I the only one who thinks immortality is a nightmare? I don't understand people who want to live forever.

HN is the only place where I’ve seen people purpose immortality as a legit goal. I think it’s because of lack of religion. If you are existentially scared of death and you are a techie, it makes sense

Not to self-own or anything but I'm religious and lots of religions have a message of immortality for the virtuous, e.g. Christianity, Islam. But our method of achieving it is spiritual, not technical. I think pretty much every normal person fears death right up to the end, unless they're seriously suffering in their body.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#37

Post by bornfreddy »

EarlKing wrote: post #30
IshKebab wrote: post #27

Earlier quoted context omitted.

We've got to be careful or we're going to end up with super-intelligent immortal mice!

Yes, but then we might get the answer.

Getting the question might be a bit more challenging though.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#38

Post by jamesblonde »

Epigenetics is fascinating. I just came back from a project meeting, where i work with people who discovered that HRT (hormone replacement therapy) slows down epithelial cell aging. Epithelial cells are the cells that cover all your vital organs, so they are important for aging.

Now, there are even commercial companies that measure Epigenetic age of cells with a technique called DNA methylation.

References: https://investinaustria.at/en/news/2022/03/epigenetic-clock-...

https://www.mydnage.com/?gclid=Cj0KCQjwheyUBhD-ARIsAHJNM-Mrk...

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#39

Post by bowsamic »

veltas wrote: post #36
bowsamic wrote: post #32

Earlier quoted context omitted.

HN is the only place where I’ve seen people purpose immortality as a legit goal. I think it’s because of lack of religion. If you are existentially scared of death and you are a techie, it makes sense

Not to self-own or anything but I'm religious and lots of religions have a message of immortality for the virtuous, e.g. Christianity, Islam. But our method of achieving it is spiritual, not technical. I think pretty much every normal person fears death right up to the end, unless they're seriously suffering in their body.

I’m a Buddhist and fear of death is one of the first things we work to get rid of
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