Long Covid risk falls only slightly after vaccination, study shows

I am wondering how much immune "budget" do humans have for vaccines? This topic is left unadressed and is extremely worrying, being an existential risk. Basically, the body has a limited amount of unspecialized naive T cells in its lifetime, mostly located/modulated in the thymus gland, which involute quickly with age.

I suppose that 1) vaccines increase the rate of specialisation of naive T cells to mature t cells (hence the number of naive t cells diminish supraphysically)and I also believe that

2) those specific mature T cells, generating covid spike protein specific antibodies, have lost some or total ability to fight non-covid diseases as a cost of specialization. 1) would increase thymus involution rate and therefore age speed of immunosupression.

2) would reduce generic immune ability (learning other pathogens)

3) I believe the increased immune profile after a vaccine induce a long lasting (at least 6 month) increase of accelerated aging process in humans, via increased inflammation and therefore apoptosis, DNA mutations and oxidative stress, although in a mild form and hence in the medium term asymptomatic.

Above all the premises I enumerated, the 2) is the one I would draw the most attention to, which can be reformulated as: do the repetitive administrations of a vaccine (here the 3 mRNA doses), reduce the effectiveness of the immune system for future non-COVID diseases, and even more importantly, does those doses reduce the immune learnability budget and therefore do those vaccines reduce the effectiveness of future vaccines against the next non-COVID pandemic? There has to be a limit to immune memory, the question is, after how many vaccines do the effect become non-negligible on aging?

study backing chronic inflammation and therefore accelerated aging: > vaccine-induced hypermetabolic lymph nodes https://pubmed.ncbi.nlm.nih.gov/34857663/

study backing the depletion of lymphocite T helper cell production: Study Shows Immune Cells Against Covid-19 Stay High in Number Six Months After Vaccination https://www.hopkinsmedicine.org/news/newsroom/news-releases/....

Moreover, I have an issue understanding why would vaccine not massively lose effectiveness after the age of 70 since at 70 the thymus has ~completely involuted (although maybe the stem cells in the bone marrow suffice?).

I have taken both jnj and Moderna. But I have to admit that the grandparent has a point. It feels it’s almost heretical to say, but the vaccines were terribly over-sold. In the beginning they were sold as traditional vaccines - prevention against infection not just serious disease. But very soon we saw “breakthrough infections” (not even written about anymore as they are so common) and the goal posts started being moved.

Public health establishment deserves a D- for their handling of the pandemic starting basically on day 1.

Were you infected with Corona? Because "Heart-disease risk soars after COVID — even with a mild case"

https://www.nature.com/articles/d41586-022-00403-0

> I am wondering how much immune "budget" do humans have for vaccines? ... Basically, the body has a limited amount of unspecialized naive T cells in its lifetime

I'm not a medical professional, so I suspect that my opinion is just as much gibberish as yours clearly is, but with more self-awareness.

Anyway, why would that "budget" be "for vaccines" _only_ ? Vaccines trigger the same mechanism as actual viral attacks, so you may as well ask "does the human immune system have a limited budget to respond to repeated viral attacks". It's the same question. And consider what answer would have better evolutionary fitness.