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Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

pubs.acs.org

31–40 of 139 posts

Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

#31
post #13

Too many "promising" studies like cannabis, vitamin D, chloroquine, ivermectin, etc have been later fact-checked by the CDC as bad science, to rely on anything but the CDC's word (or Fauci). Until the CDC says so I won't believe it. Right now it seems like mass vaccination is our only way out of this pandemic and back to normal.

Did the CDC say so about this study? Source?

The same CDC that said early on that we don't need masks when the WHO advised them. It wasn't to keep the general public COVID free, it was to make sure there were enough masks for healthcare workers. CDC incentives aren't aligned with individual health, it's more for social health and getting people back to work without maxing out healthcare systems.

The scientific community should be fact checking and reproducing these studies.

The thing with cannabis, vitamin D, ivermectin, they have been around for years and have low risk profile in human use with billions of doses. Even if it is experimental and there aren't long term studies, all the science for mRNA vaccines in humans is new and there are no long term studies. So why not throw everything at the pandemic instead of hoping and dreaming for vaccines alone to save us.

We are a few mutations away from omicron contagiousness with delta symptoms. I don't see how vaccines alone are going to stop this thing. This current wave is not dropping to zero.

Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

#33
post #18
post #13

Too many "promising" studies like cannabis, vitamin D, chloroquine, ivermectin, etc have been later fact-checked by the CDC as bad science, to rely on anything but the CDC's word (or Fauci). Until the CDC says so I won't believe it. Right now it seems like mass vaccination is our only way out of this pandemic and back to normal.

Since the vaccinations are stopping the spread?

95% of people in New Zealand that are eligible for a vaccine are vaccinated. A population of five million are getting ~30 new cases a day when excluding cases at the border on entry (50 including the border cases).

People are causing the spread, not the vaccine.

Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

#34

Totally anecdotal but my girlfriend and I recently went to wedding and even with pre testing and everyone vaccinated, a lot of people got Covid. I was super high that night (as most nights) and walked away unscathed. Obviously this could be due to a lot of things but that hasn’t stopped me from rubbing it in all my friends faces. It’s been of the few times in my life where my weed habit looks smart, and I’m loving ev…

A year ago my wife got Covid. She isolated in our bedroom and I was quarantined in the rest of the house. I spent my time getting high and watching movies. I took multiple PCR tests and an antibody test and they were all negative.

> It’s been of the few times in my life where my weed habit looks smart, and I’m loving every minute of it.

Indeed :)

Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

#35
post #17
post #13

Too many "promising" studies like cannabis, vitamin D, chloroquine, ivermectin, etc have been later fact-checked by the CDC as bad science, to rely on anything but the CDC's word (or Fauci). Until the CDC says so I won't believe it. Right now it seems like mass vaccination is our only way out of this pandemic and back to normal.

I would not listen to a federal govt source's opinions on weed, tbh.

That is painting with a very broad brush. For better or worse, federal government is huge. It is not exactly a monolith. It is made out of people and, not surprisingly, not all of them agree with one another.

Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

#36
post #27
post #25

Earlier quoted context omitted.

They reduce chances of hospitalization by at least an order of magnitude, and the chances of death by even more. COVID is almost certainly never going away. It will become endemic, joining the other endemic viruses such as the couple hundred cold viruses (including 4 other coronavirus that were once deadly pandemics) and the various flu viruses we reluctantly live with. Something we all get several times over our lif…

>They reduce chances of hospitalization by at least an order of magnitude, and the chances of death by even more Want to point out this was your response to the question, "Since the vaccinations are stopping the spread?" in case you wanted to re-read your answer.

That was the answer. People vocally cynical about the vaccines have always been using a strawman argument, in case you need a refresher a strawman argument requires two things:

1) creating a standard that was never used by the proponents

2) criticizing the made up standard to discredit the proponents

on a medical level, it is clear this wasn't to stop the spread, it was to slow the spread as vaccinated infected have smaller viral load for shorter time period compared to unvaccinated infected, as well as reduce severity and deaths of those that contained a viral load.

On who we call the "proponents" for this topic, I will concede that I've heard many local influencers, radio hosts and others reduce this to "stop the spread" in reference to any viral mitigation measure, such as masks, distancing, quarantine, and vaccination all part of an amorphous overarching program. But its clear that the people that latch on to "stop the spread" as a reference to the vaccine as a technical term advancement would never have looked at the technical supporting data due to either trust issues with the institution or plain ignorance of how it works. The researchers and their research has always been clear about what performance to expect from the vaccines (except duration of effectiveness which is unknown for both the vaccines and natural immunity, compounded by the variants)

Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

#37
"Our infection inhibition assay results clearly indicate that CBDA and CBGA are both able to block cell entry by SARS-CoV-2. The concentrations needed to block infection by 50% of viruses is high but might be clinically achievable. For example, CBDA administered orally to human volunteers at 0.063 mg/kg showed greater bioavailability than CBD and produced maximum plasma concentrations of 0.21 μM. (32) In beagle dogs, oral administration of CBDA at 1 mg/kg was well tolerated, was 2-fold more bioavailable than CBD, and produced serum levels up to 1.42 μM. (41) Although no data on the bioavailability of CBGA are yet available, the data for CBDA suggest that μM plasma and serum concentrations for CBGA should also be possible."

Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

#38
post #28

Earlier quoted context omitted.

Well it is a single scientific study. To believe it as fact would be a fundamental misunderstanding of how science works. I agree with the spirit of your comment in that I would hold out for more scientific replication of these results to increase my confidence beyond the level of simple curiosity.

Has there been any such replication of the "natural immunity protection is equal or greater to vaccine protection" study(s) yet?

https://www.medrxiv.org/content/10.1101/2021.08.24.21262415v...

Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

#39
Anecdote: Wife has had very mild covid for 5-6 days now. Been sharing a bong with her and I have no symptoms. I smoke much more than she does. She is boosted. I stopped after the second dose.

Also, I heard somewhere, and I forget where now, that hot smoke could play a role in this, but this study seemed to indicate it was orally bioactive as well. I would assume the in-vivo test wasn’t blowing hot smoke in a test tube but rather bathing in a cannabinoid solution?

Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

#40

This reminds me of William S Burrough’s “Cities of the Red Night,” in which a deadly plague appears suddenly. The character Dr. Pierson is a heroin addict, and helps discover that heroin is prophylactic against the fever: “A top government official bluntly warned: ‘Virus B-23 now loose in our overcrowded cities, is an agent that produces biologic changes in those affected – fatal in many cases, permanent and heredita…

Thank you for remdinding me of this fantastic book! One of my favourites.
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