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Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

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31–40 of 234 posts

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#31

Huh. This is interesting. I also have some fatigue, but my most obvious long-covid symptom is heart pain/strain which is aggravated by either an elevated heart rate or dehydration. I'm no expert, but intuitively this would seem to provide a good explanation of those symptoms.

Dehydration is not a symptom, it's a cause. Just drink more.

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#34

Are there by chance any similar tests on long covid patients using the enzymes Serrapeptase and Nattokinase? Or any of the other 30 or so related enzymes? Asking because Natto has the nice side benefit of binding to ACE2 and it is super easy to acquire. These enzymes are also Fibrinolytics. As a related question, how is Japan doing in terms of long covid cases relative to everywhere else? They eat a lot of Natto.

Why would fibrinolytics have any therapeutic effect? They are not anti coagulants (i.e. serine protease inhibitors), and work via an entirely different mechanism.

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#35
The link between microclots and long COVID is new to me and fascinating. Anecdotally, this gels with some of the symptoms I've seen in friends/family. My father had reduced motility in his arm-- where he'd broken it many years before--for many months after recovering from COVID. Then one random day, after he'd strained himself a bit, he noticed the pain/restriction completely gone, and the skin had turned slightly black in the region where it used to hurt. Not a doctor, but feels like something related to a microclot? He described the pain as almost like a twisted nerve or vein.

This HN post talks more about the link: https://news.ycombinator.com/item?id=29808020

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#36
post #29

I think I’m going to start taking aspirin. Oddly enough I took that a few times because I didn’t have ibuprofen and I do feel like it helped a lot with the weird long symptoms I am experiencing. I’m triple vaccinated before anyone asks. I haven’t tested positive for Covid on rapid tests but a lot of people seem to be in the boat I’m in right now.

I assume you have read the hint that the authors left in the introduction for people like you: "Such a regime must only be followed under strict and qualified medical guidance to obviate any dangers, especially haemorrhagic bleeding, and of the therapy as a whole."

Well yes I’m doing a very light version of the protocol, no industrial strength anticoagulants. :)

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#37
Sounds exactly like chronic fatigue syndrome, I don't know why we keep calling it Long COVID while we have a name for it.

https://www.nhs.uk/conditions/chronic-fatigue-syndrome-cfs/ > Suggested causes or triggers for ME/CFS include: > viral infections, such as glandular fever > bacterial infections, such as pneumonia > problems with the immune system > a hormone imbalance > your genes – ME/CFS seems to be more common in some families

I have a friend who got CFS out of nowhere (shortly before the 2 years to flatten the curve started, no COVID involved) and it's bad, there is no cure and it's incredibly disruptive. At the same time, it's hard for people to take you seriously and not just call you lazy.

Hopefully this study goes somewhere and we'll find a cure for CFS.

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#38
post #8

Huh. This is interesting. I also have some fatigue, but my most obvious long-covid symptom is heart pain/strain which is aggravated by either an elevated heart rate or dehydration. I'm no expert, but intuitively this would seem to provide a good explanation of those symptoms.

I'm hopeful that research into whatever "long covid" syndrome is/isn't leads to excellent new medical knowledge that applies to much more than just COVID edge-cases. I suddenly got similar symptoms since getting a nasty version of strep throat last October. Notably I had an elevated fever (>102F) for quite a few days straight. I've never had COVID but I did get the mRNA vaccines + booster. Since that fever, my heart…

> I've never had COVID but I did get the mRNA vaccines + booster.

> my heart goes into light arrhythmia all too frequently. It used to be maybe once or twice a year I'd notice 1-3 seconds of "off-beat" heart pattern. All of of a sudden it's a few times a week. I'm also getting older (entering mid 30's now)

This is my situation exactly, starting a few weeks after getting my second booster (Moderna). I've read enough anecdotes and news reports to believe there are many people dealing with this:

https://www.cbc.ca/news/canada/ottawa/myocarditis-ottawa-mrn...

https://ottawacitizen.com/news/local-news/she-thought-she-wa...

It gradually improved (enough to stop waking me up), but I still get a lot more "off-beats" than I used to. Got my third booster recently (Pfizer), so far no major regressions.

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#39
post #8

Earlier quoted context omitted.

I'm hopeful that research into whatever "long covid" syndrome is/isn't leads to excellent new medical knowledge that applies to much more than just COVID edge-cases. I suddenly got similar symptoms since getting a nasty version of strep throat last October. Notably I had an elevated fever (>102F) for quite a few days straight. I've never had COVID but I did get the mRNA vaccines + booster. Since that fever, my heart…

Tell your doctor about your symptoms and then ask for an ECG. You want to know if you have an underlying heart condition. Depending on what you find, there may be options that will eliminate your arrhythmias.

Anecdotally, I also had arrhythmia and after a few months and visits to doctors I figured out it was the type of coffee I drank. Changed back (from Espresso so standard) and the arrythmia was gone. YMMV

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#40

Are there by chance any similar tests on long covid patients using the enzymes Serrapeptase and Nattokinase? Or any of the other 30 or so related enzymes? Asking because Natto has the nice side benefit of binding to ACE2 and it is super easy to acquire. These enzymes are also Fibrinolytics. As a related question, how is Japan doing in terms of long covid cases relative to everywhere else? They eat a lot of Natto.

Why would fibrinolytics have any therapeutic effect? They are not anti coagulants (i.e. serine protease inhibitors), and work via an entirely different mechanism.

Absolutely not anti-coagulants. They work in conjunction with them to break up clots and absolutely have many different mechanisms. I use six of those mechanisms for controlling blood pressure.

The article topic covers fibrin amyloid microclots which is precisely what many surgeons have used these enzymes for in addition to removing scar tissue from the vasculature. On a side note this is a very divided and heated topic within the different groups of heart surgeons.

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