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Little Exercise, Big Effects: Reversing Aging

jneurosci.org

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Re: Little Exercise, Big Effects: Reversing Aging

#31

Post by kragen »

Mz wrote: post #22
Alex3917 wrote: post #15

Earlier quoted context omitted.

"Are you aware of any research into the potential differences?" Not off the top of my head, but here are some links to 'databases' of hundreds or thousands of research articles on cannabinoids: http://www.letfreedomgrow.com/cmu/GrannysList-Jan2011.pdf http://www.cannabis-med.org/studies/study.php http://www.cannabis-med.org/index.php?lng=en In general though I think cannabis is a good example of why plant-based medic…

Totally off topic, but do you happen to know anything about capsaicin? I began eating hot peppers a few months ago and it had a dramatic impact on my condition. CF is rooted in a defect in a cell channel, the CFTR, which handles trafficking of certain molecules into and out of the cell. Capsaicin, the active ingredient in hot peppers, forces a different channel open at lower than normal temps. I asked around and got…

I looked it up, and I think "CF" means "cystic fibrosis", a congenital lung disease that is usually fatal in early life.

Re: Little Exercise, Big Effects: Reversing Aging

#32

Post by asifjamil »

cpeterso wrote: post #24
asifjamil wrote: post #17

Interesting article. I remember reading somewhere the opposite hypothesis. The argument went like this: more exercise --> faster metabolism --> faster consumption of your body utilities --> lower life expectancy

Well, the study is called "[A] Little Exercise, Big Effects" , not "More Exercise, More Results."

not sure what you mean. i was pointing out an opposite effect.

Re: Little Exercise, Big Effects: Reversing Aging

#33

Post by Mz »

kragen wrote: post #31
Mz wrote: post #22

Earlier quoted context omitted.

Totally off topic, but do you happen to know anything about capsaicin? I began eating hot peppers a few months ago and it had a dramatic impact on my condition. CF is rooted in a defect in a cell channel, the CFTR, which handles trafficking of certain molecules into and out of the cell. Capsaicin, the active ingredient in hot peppers, forces a different channel open at lower than normal temps. I asked around and got…

I looked it up, and I think "CF" means "cystic fibrosis", a congenital lung disease that is usually fatal in early life.

Yes, it stands for cystic fibrosis. Average life expectancy in the US is currently around 36 or 37, way up from age 18 roughly 18 or 20 years ago. I was diagnosed just before my 36th birthday with a milder classification of it which is emerging and is most often called "atypical cystic fibrosis". I spent a year at death's door. It's been a long haul back from there.

It's not really a lung disease. It's a genetic disorder. All cells in the body are impacted in their function. Mucus membranes are the most obviously negatively impacted. Lungs happen to be lined with mucus. So is the gut and malabsorption and lack of adequate weight gain is another major issue which is frequently life threatening but gets less press than the high incidence of lung transplant.

Re: Little Exercise, Big Effects: Reversing Aging

#34

Post by delinquentme »

Mz wrote: post #22
Alex3917 wrote: post #15

Earlier quoted context omitted.

"Are you aware of any research into the potential differences?" Not off the top of my head, but here are some links to 'databases' of hundreds or thousands of research articles on cannabinoids: http://www.letfreedomgrow.com/cmu/GrannysList-Jan2011.pdf http://www.cannabis-med.org/studies/study.php http://www.cannabis-med.org/index.php?lng=en In general though I think cannabis is a good example of why plant-based medic…

Totally off topic, but do you happen to know anything about capsaicin? I began eating hot peppers a few months ago and it had a dramatic impact on my condition. CF is rooted in a defect in a cell channel, the CFTR, which handles trafficking of certain molecules into and out of the cell. Capsaicin, the active ingredient in hot peppers, forces a different channel open at lower than normal temps. I asked around and got…

this is awesome.

good research man.

Re: Little Exercise, Big Effects: Reversing Aging

#35

Post by [deleted] »

delinquentme wrote: post #34
Mz wrote: post #22

Earlier quoted context omitted.

Totally off topic, but do you happen to know anything about capsaicin? I began eating hot peppers a few months ago and it had a dramatic impact on my condition. CF is rooted in a defect in a cell channel, the CFTR, which handles trafficking of certain molecules into and out of the cell. Capsaicin, the active ingredient in hot peppers, forces a different channel open at lower than normal temps. I asked around and got…

this is awesome. good research man.

[deleted]

Re: Little Exercise, Big Effects: Reversing Aging

#36

Post by bfe »

Alex3917 wrote: post #5

For what it's worth, cannabis also prevents neuroinflammation, even in extremely low doses: http://www.youtube.com/watch?v=2uVXs6CY2ps http://www.freedomtoexhale.com/clinical.pdf The endocannabinoid system seems to be the main mechanism our bodies use to naturally regulate inflammation. My understanding is that there is a growing belief among cannabinoid researchers that our cannabinoid receptors can get blocked as w…

The natural ligand for cannabinoid receptors, anandamide, is stimulated by exercise, particularly distance running. "Runner's High" is just that.

Re: Little Exercise, Big Effects: Reversing Aging

#38

Post by AngryParsley »

asifjamil wrote: post #17

Interesting article. I remember reading somewhere the opposite hypothesis. The argument went like this: more exercise --> faster metabolism --> faster consumption of your body utilities --> lower life expectancy

Exercise does cause damage to your body, both structural and oxidative. Fortunately, that damage triggers repair mechanisms which make you stronger than before. See http://en.wikipedia.org/wiki/Hormesis#Physical_exercise

An aside: Reading this article made me wonder why I tasted blood after particularly hard workouts. Apparently the heart can pump with enough pressure to rupture some of the capillaries in your lungs. A tiny amount of blood leaks out and gets aerosolized. At least, so says this paper: http://abughrai.be/Vulnerability%20of%20pulmonary%20capillar...

Re: Little Exercise, Big Effects: Reversing Aging

#39

Post by sorbus »

asifjamil wrote: post #32
cpeterso wrote: post #24

Earlier quoted context omitted.

Well, the study is called "[A] Little Exercise, Big Effects" , not "More Exercise, More Results."

not sure what you mean. i was pointing out an opposite effect.

The above poster is - as I understand it - pointing out that this study does not necessarily contradict the hypothesis you mentioned. A small amount of exercise is shown to be beneficial, but it is entirely possible that larger amounts of exercise are detrimental.

Do you know if any research has been done into that hypothesis? Because - failing a confirming study - it does not seem to fit with anything I've heard. I mean, maybe some organs can get overwhelmed if metabolism is pushed too high too quickly, but in general I doubt that a fast metabolism even correlates with lower life expectancy.

Re: Little Exercise, Big Effects: Reversing Aging

#40

Post by freesciencenow »

amirmc wrote: post #18
freesciencenow wrote: post #13

Paywalls for scientific research are evil. Here's the full paper: http://209.20.67.195/misc/littleexercise.pdf (See profile for why I do what I do.)

Your profile does not really explain why you do what you do (it basically repeats what you've said here). Care to expand?

As my profile says, "I do this both to help the discussion and as an act of civil disobedience."

Was there something more you wanted to know?

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