Earlier quoted context omitted.
Well, infinity is inherently unscientific, as there is no way to scientifically differentiate between an infinite quantity and a really huge quantity (same for infinitesimals), in finite time. What this means is that a universe that contains infinities is, even in theory, entirely indistinguishable (in finite time) from an universe that contains really large/small but finite quantities.
What about negative numbers? Or complex numbers? They are only tools, which can be quite useful to build models of the world with predictive powers but shouldn't be confused for the underlying reality. Even whole numbers are an abstraction that makes sense only when you can clearly define what is the thing you're counting.
The complex numbers (well, at least those with a rational imaginary part and a rational real part) have been recently proven to be necessary to describe the universe[0] (assuming quantum theory is correct).
The irrational numbers are then are the only numbers that are harder to pin down, and I'm not sure that there is a way to prove that any physical quantity has an irrational value, vs a rational value that is arbitrarily close to that irrational value.