> Here, we studied the effects of the disease in the brain using multimodal data from 782 participants from the UK Biobank COVID-19 re-imaging study, with 394 participants having tested positive for SARSCoV-2 infection between their two scans.
782 participants, 394 of which had positive tests for COVID-19, a further 15 of the 394 were hospitalized due to their symptoms.
The interpretation could be:
- lung symptoms are not correlated with brain changes
- mild infections not requiring hospitalization showed similar pathology to severe infections
> What are the quantitative findings of "loss of grey matter"?
Page 18 shows the measurements.
> What mechanism/s are suspected that might be specific to COVID19?
Page 3.
> one hypothesis is that an entry point of the virus to the central nervous system might be achieved by crossing the neural–mucosal interface in the olfactory mucosa, and progress from there onto the olfactory bulb in the brain [Meinhardt J, Radke J, Dittmayer C, et al. Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19. Nat Neurosci 2021; 24(2): 168-75.]