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Brain imaging before and after Covid-19 in UK Biobank

medrxiv.org

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Re: Brain imaging before and after Covid-19 in UK Biobank

#31

Earlier quoted context omitted.

Most of the arguments against accepting an mRNA shot read as “too new, do not want” to me. What are the specific long-term side effects that one should be aware of when accepting an mRNA shot?

It’s more the effects of free circulating spike protein in the bloodstream than mRNA triggering ribosomes.

I don't understand what you are saying.

What is the significance of either of those?

Re: Brain imaging before and after Covid-19 in UK Biobank

#32
post #8

Earlier quoted context omitted.

If many people do what you are doing, some percentage can get the virus and allow it to mutate further, reducing the vaccine efficiency, putting others to risk. Prisoner's dilemma at play. meta edit: I don't like your post becoming completely gray and therefore up-voted you. It's a view that many people hold and it needs to be answered not by screaming "down-vote the selfish!" but rather with good arguments.

Oh 100%. It's a selfish play I admit. But if there's greater than zero risk of any long-term unknown effects from a vaccine, the number of people already vaccinated means the expected value is probably negative for anyone who hasn't been vaccinated yet.

There seems to be a sizeable number of people who don't want to vaccinate, plus children under 12 won't be, and also the pandemic will survive in developing countries and travelers coming from them for a while.

So I think the risk of getting infected in fall may well be significant enough to make taking the vaccine a good decision.

Plus of course by vaccinating you no longer need to worry about minimizing infection risk, you don't need to get fake certificates to access things that are restricted to vaccinated people, you are free to travel to developing countries without risk.

Also if you don't vaccinate now and the pandemic somehow has a resurgence you will have to rush to vaccinate then and stay at least month in full isolation while others who are vaccinated are freely going to events instead of doing the isolation now that events haven't fully resumed yet.

Re: Brain imaging before and after Covid-19 in UK Biobank

#33
post #24

Earlier quoted context omitted.

What is the percentage of people who suffered any long term brain effects? And did they do the same study against people who got the flu and other diseases?

> And did they do the same study against people who got the flu and other diseases? Does this matter?

Hard to tell in advance, without the information. Was this a flippant dismissal or a genuine question?

Re: Brain imaging before and after Covid-19 in UK Biobank

#34

I wish I could get people that are avoiding the COVID vaccine “because we don’t know what the long term effects are” to realize that we have real data showing that there are long term effects from getting full blown COVID. You don’t want a tiny piece of mRNA but you want the whole organism reproducing in your body? The whole genome and all the proteins made?

Yeah. I had complete loss of smell and taste, which came back about 90% over the next six weeks. It was fine for a month and then it went wonky. Probably 30% of my "scent spectrum" has now been replaced with the same burnt meat smell/taste. Everything from chocolate to feces to hamburgers now has the same core odor. It really, really sucks.

Did getting vaccinated change anything ? I've heard that vaccinations helped people with long COVID.

Hope you recover fully.

Edit: since someone asked for citations, here is a CNN link

https://us.cnn.com/2021/04/03/health/long-haulers-vaccine-we...

I follow the "This week in virology" podcast and they have discussed this extensively as well. Dr Daniel Griffin, cited in the CNN article is a weekly contributor on this podcast, and has mentioned the effect in question multiple times.

Re: Brain imaging before and after Covid-19 in UK Biobank

#35
post #24

Earlier quoted context omitted.

What is the percentage of people who suffered any long term brain effects? And did they do the same study against people who got the flu and other diseases?

> And did they do the same study against people who got the flu and other diseases? Does this matter?

Would be interesting to know. If you're alarmist about COVID affecting brain tissue long term and we have protections against other diseases that also have long term effects on brain tissues, it reasons to me that you should also be as adamant if not more for protecting against those diseases.

There's a lot of funding studying COVID, for good reasons. Why not use those findings to further other areas as well? We now have some interesting comparisons to look at. Might be even more good reasons to promote getting your annual flu shot.

Re: Brain imaging before and after Covid-19 in UK Biobank

#36

I wish I could get people that are avoiding the COVID vaccine “because we don’t know what the long term effects are” to realize that we have real data showing that there are long term effects from getting full blown COVID. You don’t want a tiny piece of mRNA but you want the whole organism reproducing in your body? The whole genome and all the proteins made?

> we have real data showing that there are long term effects from getting full blown COVID.

As in, 90% (probably more because asymptomatic people are never tested) of people actually have no symptoms at all and seem to go along fine with it? Or are you talking about something else?

Re: Brain imaging before and after Covid-19 in UK Biobank

#37

Earlier quoted context omitted.

Most of the arguments against accepting an mRNA shot read as “too new, do not want” to me. What are the specific long-term side effects that one should be aware of when accepting an mRNA shot?

It’s more the effects of free circulating spike protein in the bloodstream than mRNA triggering ribosomes.

And cytotoxicity - with the second shot, the body will have cytotoxic T cells which could target some of the transfected cells.

But, why not to be worried:

- It's a normal process and most cells will be replaced.

- The effects would be tiny, especially compared to an infection with the real thing. If this was causing widespread issues, we would know by now.

- All studies done so far indicate that only a very small amount will enter systemic circulation.

It's a classic risk tradeoff, and the risks of taking the vaccine are much smaller than the risk of getting the real infection (billions of viruses replicating vs. one-time dose, real spike protein vs. stabilized spike protein).

Re: Brain imaging before and after Covid-19 in UK Biobank

#38
post #24

Earlier quoted context omitted.

What is the percentage of people who suffered any long term brain effects? And did they do the same study against people who got the flu and other diseases?

> And did they do the same study against people who got the flu and other diseases? Does this matter?

> Does this matter?

Who knows? Maybe there's a ton of viral infections out there that cause some form of brain damage and get no attention at all. Attention bias at play.

Re: Brain imaging before and after Covid-19 in UK Biobank

#40

This sounds alarming: > There is strong evidence for brain-related pathologies in COVID-19, some of which could be a consequence of viral neurotropism. This doesn't: > We further compared COVID-19 patients who had been hospitalised (n=15) with those who had not (n=379), and while results were not significant, we found comparatively similar findings to the COVID-19 vs control group comparison What are the quantitative…

> Here, we studied the effects of the disease in the brain using multimodal data from 782 participants from the UK Biobank COVID-19 re-imaging study, with 394 participants having tested positive for SARSCoV-2 infection between their two scans.

782 participants, 394 of which had positive tests for COVID-19, a further 15 of the 394 were hospitalized due to their symptoms.

The interpretation could be:

- lung symptoms are not correlated with brain changes

- mild infections not requiring hospitalization showed similar pathology to severe infections

> What are the quantitative findings of "loss of grey matter"?

Page 18 shows the measurements.

> What mechanism/s are suspected that might be specific to COVID19?

Page 3.

> one hypothesis is that an entry point of the virus to the central nervous system might be achieved by crossing the neural–mucosal interface in the olfactory mucosa, and progress from there onto the olfactory bulb in the brain [Meinhardt J, Radke J, Dittmayer C, et al. Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19. Nat Neurosci 2021; 24(2): 168-75.]

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