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What we learned doing Fast Grants

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Re: What we learned doing Fast Grants

#31

> Making human clinical trials cheaper and quicker is probably one of the biggest opportunities for improving U.S. healthcare both during and beyond pandemics. The failure to accelerate vaccine development through challenge testing is a black mark on our ethical and regulatory system. the Moderna vaccine mRNA was developed two days after COVID-19 was identified, yet it took over a year to get through human testing. A…

Keep in mind that vaccines solve a systemic problem, and a bad vaccine can exacerbate a pandemic. Yes, vaccines can be made in a day or two, but it takes a long time to know if they are effective.

Re: What we learned doing Fast Grants

#32

The US went all in on vaccines. I'm disappointed but not surprised that the US didn't fund more academic R&D; that's the MO I expected during that administration.

There's plenty of funding for academic R&D (https://grants.nih.gov/grants/guide/COVID-Related.cfm), TFA focuses on how slow it took to get that funding or repurpose existing funding.

I was following some research into repurposing existing drugs for COVID that started early last year. Only last month did they complete gathering enough people for the experiment.

Re: What we learned doing Fast Grants

#34
post #10

Fast Grants, but to fight climate change?

I'm not Patrick Collison, but if I were then I might say that there are already a bunch of impressively plausible-looking carbon capture and sequestration technologies, they look like our best bet on the margin, and what they mostly need is a large enough early customer base to let them scale up and reduce cost.

As it happens, there's a program called Stripe Climate which aims to do exactly this! Money comes from Stripe and from businesses that would like to be able to truthfully say that they donate a percentage of purchases to fight climate change. It looks well thought-out and credible, at least to my eye. They elaborate more on the rationale here:

https://stripe.com/climate

Re: What we learned doing Fast Grants

#35
post #24

Earlier quoted context omitted.

How about we quit treating people like children and make all drugs legal? The FDA stamp will just be a stamp of quality to help guide people to a known quality product. No enforcement of drug laws at the barrel of an authorities gun. But if people want to do some experimental off brand use that their doctor recommends then they can. If people do their own research and want to self prescribe they can. Getting the mono…

I've thought the same thing and generally agree with it. Why shouldn't I be able to walk to CVS and pick up a bottle of heroin and various prescription drugs? I'm an adult; I shouldn't even owe anyone an explanation. At the same time, I think we would need to concurrently ban drug advertisements as other countries have. To me, that seems like a better balance between treating individuals as adults with autonomy and m…

The reason you can't go to CVS and pick up heroin or crack is:

Inevitably, lots of people would become addicted and there would be many deaths.

Very critical news stories would run. People neglecting their children to use drugs. Testimonies of loved ones and shattered families.

Politicians would be inundated with calls to regulate these dangerous substances.

Politicians who refused to do anything would be mired in conspiracy theories, accusations of conflict of interest and profiting from suffering. They would be voted out and replaced.

Regulation ensues.

Re: What we learned doing Fast Grants

#36

Individuals are more ready to take risks than institutions. To me this was the most damning indictment of all. Once founders leave a compnay (or an institution), as BalajiS says, they become a shell of their former selves,with the individuals mostly in for self-preservation rather than set out fulfill the purpose of the institution.

An indictment, or just an admission that we're not generally willing to make?

What would happen, for example, if we handed the entire education budget to teachers directly. No controls, reporting requirements... just a stack of cash? Teacher decides how to spend it. My guess is that we would see some amazingly positive things. We would also see some awful things. Fraud, failure, scandal... Perhaps, probably even, the average result would be good. Could we stomach the price though? Would year 10 be better or worse than year 1?

We tend to be scandalised by bad things, and take good things for granted. Hence controls.

"Let’s do it” was then the basic attitude and we were much more worried about missing out on supporting important work than looking silly"

Fine attitude, given the circumstances. Outside of seed funding and research though... is it viable? Is it viable after 10 years of repetition? Can it survive scandalous articles highlighting blatant abuses, face up to scrutinies year after year?

There are differences between early and late stage "games." Run this as a long term program, and scams might flood in. More insidious perhaps, proposals that are not quite scams. Observers are also less forgiving of repetitive "failures." Would the director of such a fund be willing to say "we will do nothing" to questions about fraud, scandal or whatnot? Would they want to?

Google once had 20% time, for similar reasons. Let smart people do what they do on their own. It devolved. They tried to fix it with controls. It sucked and then they killed it. The attempt was earnest, but the destination was precisely what G we're trying to avoid.

I'm not disagreeing with this author or the general sentiment on this thread. Getting past or around institutional mindsets is high potential. This project sounds great. We need these to exist.

I am saying that it's unwise to underestimate something this prevalent.

I'm reminded of a Dan Ariely quote about why daughters want bad boys on proverbial motorcycles, but parents hate them. Mothers don't get to ride the motorcycle, but they do get to deal with the consequences.

A lot of this relates to high risk, high reward stuff. Research, startups, etc. Employees, even CEOs are never compensated (including non money incentives) in a way that reflects true risk/reward.

Re: What we learned doing Fast Grants

#37

Individuals are more ready to take risks than institutions. To me this was the most damning indictment of all. Once founders leave a compnay (or an institution), as BalajiS says, they become a shell of their former selves,with the individuals mostly in for self-preservation rather than set out fulfill the purpose of the institution.

I wouldn't call it a damning indictment.

You set up institutions to protect the status quo. Individuals can go ahead with risks and experiments, but you don't want to risk an entire society with someone's wild idea. For every wild idea that works out, there's many more that didn't.

Of course we should mitigate risks before potentially destroying society.

Re: What we learned doing Fast Grants

#38
"This is an instance of a broader theme: we were surprised that many entities continued with something close to “business as usual” rather than switching to emergency pandemic mode"

I think we need to codify what "emergency mode" is and when we switch to it. Bureaucracies, and those working in them, need to understand when the situation is not "business as usual" and get out of the way! Implicit in that is, when we are in emergency mode, more risk is taken, there is less red tape, we expect side effects and damage, but we also expect faster progress. We can't just expect systems designed to be slow and cautious to instantly flip to aggressive explorers without defining what we expect and when to do it.

Re: What we learned doing Fast Grants

#39

Individuals are more ready to take risks than institutions. To me this was the most damning indictment of all. Once founders leave a compnay (or an institution), as BalajiS says, they become a shell of their former selves,with the individuals mostly in for self-preservation rather than set out fulfill the purpose of the institution.

On the flip side, there are basically no institutions that campaigned against vaccine adoption, whereas there are many prominent celebrities and politicians who did.

Re: What we learned doing Fast Grants

#40

> Making human clinical trials cheaper and quicker is probably one of the biggest opportunities for improving U.S. healthcare both during and beyond pandemics. The failure to accelerate vaccine development through challenge testing is a black mark on our ethical and regulatory system. the Moderna vaccine mRNA was developed two days after COVID-19 was identified, yet it took over a year to get through human testing. A…

How about we quit treating people like children and make all drugs legal? The FDA stamp will just be a stamp of quality to help guide people to a known quality product. No enforcement of drug laws at the barrel of an authorities gun. But if people want to do some experimental off brand use that their doctor recommends then they can. If people do their own research and want to self prescribe they can. Getting the mono…

The only reason I like this idea is that we know a certain political segment of society would of been killed off by dumb decisions in this area via hydroxychloroquine.
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