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DARPA Awards Moderna a Grant for Up to $25M to Develop mRNA Therapeutics (2013)

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31–40 of 68 posts

Re: DARPA Awards Moderna a Grant for Up to $25M to Develop mRNA Therapeutics (2013)

#31
post #27

So why are we paying 10 times the production price since this product has been payed by public funds ?

Read, Debt the First 5000 years by David Graeber. Which outlines what markets are really about. Markets are a tool for the government to provision itself. The government creates markets. The myth that markets were created because barter was annoying is plain wrong.

Re: DARPA Awards Moderna a Grant for Up to $25M to Develop mRNA Therapeutics (2013)

#32
post #28
post #22

A big myth often told in the tech world that things are developed by startups using private equity. We often forget the large and dynamic public sector. Biggest "VC" in the world is DARPA and other US government entities. EDIT: I meant to say, it's a big myth the tech industry tells the public.

It is not a myth, but well known. Startups take something that is already researched, and further develop it and commercialize/monetize it. I think the myth might be more in the layman/general population, but most people in the tech world know this.

Yes! I guess I should be more precise thanks. It's a myth the tech world propagates to the general public. Updated my original comment.

Re: DARPA Awards Moderna a Grant for Up to $25M to Develop mRNA Therapeutics (2013)

#33
post #7

> Defense Advanced Research Projects Agency (DARPA) > make antibody-producing drugs to protect against a wide range of known and unknown emerging infectious diseases and engineered biological threats This is amazing. I need to follow their other grants now to see what they’re looking at

Enjoy! https://www.darpa.mil/work-with-us/opportunities

> COMPUTATIONAL CULTURAL UNDERSTANDING (CCU)

This![0]

[0] https://beta.sam.gov/opp/a6d0788057414e2c8fd6bdf45e3fd21d/vi...

[PDF¹] https://www.darpa.mil/attachments/CCUProposersDayFAQ%20v15.p...

[PDF²] https://www.darpa.mil/attachments/CCUProposersDayBriefv7.pdf

[PDF³] https://www.darpa.mil/attachments/HR001121S0024-Amendment-01...

Re: DARPA Awards Moderna a Grant for Up to $25M to Develop mRNA Therapeutics (2013)

#34
post #27

So why are we paying 10 times the production price since this product has been payed by public funds ?

Grants encourage early R&D, Purchasing Commitments encourage Product Development and Capital Investments. We can do more of both.

Re: DARPA Awards Moderna a Grant for Up to $25M to Develop mRNA Therapeutics (2013)

#35
post #4

This is why tax avoidance is a bad thing. Governments can accelerate innovation with stimulations like this.

Looks like DARPA's budget is about 3.5 billion a year vs. the overall defense budget of something like 715 billion. I'm betting that a lot more people would feel ok about paying taxes if more of it was going towards these types of projects rather than empire building in far away parts of the world.

The U.S. isn't empire building. It's mainly a policy of retaining superpower status for world peace.

Containment of China, Russia, Iran, and North Korea is largely the defining policy of the last 70 years.

Of course tons of blunders like Vietnam and Afghanistan. Tragedies. But there has not been a World War III nor have there been large scale wars killing a sizable portion of the populace such as most wars pre-WWII.

For further evidence that the U.S. isn't interested in empire building is the fact that in wars over the last 70 years, the U.S. hasn't gained land and tried to turn the countries into vassal states like in classical European wars or like USSR did. The U.S. aims to build allies not an empire.

Re: DARPA Awards Moderna a Grant for Up to $25M to Develop mRNA Therapeutics (2013)

#36
post #4

This is why tax avoidance is a bad thing. Governments can accelerate innovation with stimulations like this.

Looks like DARPA's budget is about 3.5 billion a year vs. the overall defense budget of something like 715 billion. I'm betting that a lot more people would feel ok about paying taxes if more of it was going towards these types of projects rather than empire building in far away parts of the world.

Defense is business in an abstract sense. DaaS is desirable for many nations instead of building domestic capability which would be far worse due to scale/reinventing-the-wheel. Look up US defense treaties with various nations across the world - this is a mutual agreement in exchange for IP, defense sales, assurance and guarantees, soft power, etc.

Re: DARPA Awards Moderna a Grant for Up to $25M to Develop mRNA Therapeutics (2013)

#37
post #7

> Defense Advanced Research Projects Agency (DARPA) > make antibody-producing drugs to protect against a wide range of known and unknown emerging infectious diseases and engineered biological threats This is amazing. I need to follow their other grants now to see what they’re looking at

Enjoy! https://www.darpa.mil/work-with-us/opportunities

Has anyone here gone through this process? What is it like compared to YC?

Re: DARPA Awards Moderna a Grant for Up to $25M to Develop mRNA Therapeutics (2013)

#38

> Defense Advanced Research Projects Agency (DARPA) > make antibody-producing drugs to protect against a wide range of known and unknown emerging infectious diseases and engineered biological threats This is amazing. I need to follow their other grants now to see what they’re looking at

DARPA also funded HackRF development, afaik still cheapest SDR with TX capability.

Re: DARPA Awards Moderna a Grant for Up to $25M to Develop mRNA Therapeutics (2013)

#39

Earlier quoted context omitted.

I wonder if it’s possible to calculate a rate of return on that. How much worse off would we be now without mRNA vaccines? I doubt anyone would be complaining about blood clots.

Seems like China did fine with more conventional vaccine technologies. I'm glad we have another tool in the toolbox, but I am missing why the mRNA vaccine tech was necessary for COVID.

I think if we still had AstraZeneca we would not be in an awful position - but that vaccine already had a massive supply constraint - the EU is still pretty pissed about that. So if there were no other vaccines that would be worse for starters.

Also, as others have pointed out, it’s more effective.

Correct me if I’m wrong about this but it seems to be deceptive to think about it in terms of effectiveness.

60% doesn’t seem that much worse than 95%. Feels like 2/3 as good.

But if you look at it the other way around it’s 40% vs 5% which makes the gap much clearer - 8X more people getting symptoms (not sure what the data is on hospitalisation / deaths is though, probably closer)

Plus I believe mRNA vaccines should end up being cheaper in the long run.

Oh and plus you don’t feel as bad after getting them.

Re: DARPA Awards Moderna a Grant for Up to $25M to Develop mRNA Therapeutics (2013)

#40
post #35

Earlier quoted context omitted.

Looks like DARPA's budget is about 3.5 billion a year vs. the overall defense budget of something like 715 billion. I'm betting that a lot more people would feel ok about paying taxes if more of it was going towards these types of projects rather than empire building in far away parts of the world.

The U.S. isn't empire building. It's mainly a policy of retaining superpower status for world peace. Containment of China, Russia, Iran, and North Korea is largely the defining policy of the last 70 years. Of course tons of blunders like Vietnam and Afghanistan. Tragedies. But there has not been a World War III nor have there been large scale wars killing a sizable portion of the populace such as most wars pre-WWII.…

> But there has not been a World War III nor have there been large scale wars killing a sizable portion of the populace such as most wars pre-WWII.

This is as much if not more of a result of Mutually Assured Destruction due to nuclear weapons. Humanity finally built something so destructive we had to collectively choose not to use it because the only way to win that game is not to play it.

Now it's all proxy wars, cyber 'wars', and trade 'wars'.

>For further evidence that the U.S. isn't interested in empire building is the fact that in wars over the last 70 years, the U.S. hasn't gained land and tried to turn the countries into vassal states like in classical European wars or like USSR did. The U.S. aims to build allies not an empire.

This much I agree with.

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