31–40 of 389 posts
I expected to have to scroll through pages upon pages of indecipherable text. Instead it's no bigger than a large paragraph of text, and I can easily fit it on my screen.
I’m a little confused by the title? Looking at the document, it seems to me (knowing next to nothing about this field) it includes both Pfizer and Moderna’s protein spike sequence in figures 1 and 2, respectively. Is that correct? It’s also interesting the way it’s worded: that the sequence was “assembled from $vaccine”. Does that mean whoever published this has backed into these sequences rather than having gathered…
So reverse engineering basically.
Wow Looks like it is analogous to having a header on a TCP packet. [0] Here is an animation of mRNA encoding translated to proteins inside a ribosome. [1] "The ribosome is composed of one large and one small sub unit that assemble around the messenger RNA, which then passes through the ribosome like a computer tape. The amino acid building blocks, that's the small glowing red molecules, are carried into the ribosome…
I’m a little confused by the title? Looking at the document, it seems to me (knowing next to nothing about this field) it includes both Pfizer and Moderna’s protein spike sequence in figures 1 and 2, respectively. Is that correct? It’s also interesting the way it’s worded: that the sequence was “assembled from $vaccine”. Does that mean whoever published this has backed into these sequences rather than having gathered…
“Assembly” in this case means that they merged several short sequences they obtained, each representing a fragment of the whole mRNA sequence.
People joked a lot about "injectible source code / machine code" but it is kind of interesting injecting yourself with something that has the source on github.
We aren’t that different from machines, we just need to know more about the CPU and all the co-processors and how the logic gates interact But for now we can inject code to trigger protein configuration via the immune system
Except it is unfortunately not that simple, because it assumes that distinct components such as CPU, co-processors and even logic gates exist in that context, as is totally reasonable to assume on devices created by humans. Abstracting complex machines into distinct components is a proven strategy to engineer a system, but it's not a necessity for functioning systems to exist.
In the case of natural organism, they "just" need to work. They don't have a blueprint, and they don't need to be organized in a way that allows for easy understanding by looking at individual parts in separation.
Consider also the difference between machine learning through neural networks ("we stuff a lot of training data in there and get what we want eventually, we hardly understand what the model does or why it fails"), and a QR code reader ("we carefully designed the format from the top down, including e.g. framing, error correction, and several invariants like rotation; if a QR code does not get recognized, we can usually tell exactly where and why it failed").
What are the purple and blue sections after the stop codon for? I read a little about the 3' region, but for the vaccine, are these sections taken from a particular natural human sequence, or specially engineered for something else?
You want it as high as possible to make as much spike protein as possible.
It's proprietary information, mostly they try various possibilities until they find one with high expression.
The thinking behind attaching a PDF with colors and not a Genbank file is why we can't have nice things in biotechnology.
so how are the first and the second dose different?
You should really do something about it because it's probably serious.
The same way, the immune system gets really triggered when it sees the same thing which it supposedly cleared at a later date.
I'm sure it's more complex than I grasp as a layperson, but I'm utterly amazed at how simple this _appears_. I get the feeling that this is something I have a better chance of understanding than the average SaaS Terms and Conditions. I expected to have to scroll through pages upon pages of indecipherable text. Instead it's no bigger than a large paragraph of text, and I can easily fit it on my screen.