Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Early clinical trial shows anti-depressant prevents hospitalization from Covid

jamanetwork.com

Post reply on HN
Print view View original

31–40 of 116 posts

Re: Early clinical trial shows anti-depressant prevents hospitalization from Covid

#31

Post by lambdaba »

mrob wrote: post #29
lambdaba wrote: post #15

Earlier quoted context omitted.

Yes, dosage should be 10k IU / day for starters with 5mg vitamin K2. Fat-soluble so take with a meal. Vitamin D depletes Vitamin A and magnesium, get the former from foods and supplement the latter as magnesium glycinate and/or chloride. Other common & relevant deficiencies are boron and zinc, especially zinc.

10k IU/day exceeds the Tolerable Upper Intake as determined by the US's National Academy of Medicine, the European Food Safety Authority, and similar organizations. Medical doctor Deva Boone posted a report of toxicity at half that dose: https://www.devaboone.com/post/vitamin-d-part-2-shannon-s-st... This post and related posts about vitamin D were discussed on HN. See: https://news.ycombinator.com/from?site=devaboon…

I know, but that's in error:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541280/#:~:tex....

Doctors correcting vitamin D levels are finding 10k IU is a good starter dose and that is often insufficient to arrive at optimal levels.

Re: Early clinical trial shows anti-depressant prevents hospitalization from Covid

#32

Post by lambdaba »

mrob wrote: post #29
lambdaba wrote: post #15

Earlier quoted context omitted.

Yes, dosage should be 10k IU / day for starters with 5mg vitamin K2. Fat-soluble so take with a meal. Vitamin D depletes Vitamin A and magnesium, get the former from foods and supplement the latter as magnesium glycinate and/or chloride. Other common & relevant deficiencies are boron and zinc, especially zinc.

10k IU/day exceeds the Tolerable Upper Intake as determined by the US's National Academy of Medicine, the European Food Safety Authority, and similar organizations. Medical doctor Deva Boone posted a report of toxicity at half that dose: https://www.devaboone.com/post/vitamin-d-part-2-shannon-s-st... This post and related posts about vitamin D were discussed on HN. See: https://news.ycombinator.com/from?site=devaboon…

In your article the person was taking this dose for 5 years, and probably without vitamin k2 and developed hypercalcemia.

Re: Early clinical trial shows anti-depressant prevents hospitalization from Covid

#33

Post by cinntaile »

amelius wrote: post #16
JoshTko wrote: post #13

Earlier quoted context omitted.

Vitamin D has been shown to reduce severity in several different studies. Everyone should consider taking it. https://www.reddit.com/r/COVID19/search?q=vitamin+D&restrict... https://www.youtube.com/watch?v=vN30emwcNS4

Yes, but are governments recommending it? Are doctors recommending it? Is WHO recommending it? I didn't hear anything about it except from that one post on HN, which I think is quite strange. If this works, then shouldn't there be a nation-wide plan to introduce more vitamin D in the diets of people?

The NHS recommends it for example.

https://www.nhs.uk/conditions/vitamins-and-minerals/vitamin-... https://www.nhs.uk/conditions/coronavirus-covid-19/people-at...

Re: Early clinical trial shows anti-depressant prevents hospitalization from Covid

#34

Post by JoshTko »

lambdaba wrote: post #26
amelius wrote: post #20

Earlier quoted context omitted.

I believe the studies, but my question is why do we let the health system suffer if there is such a simple solution? Why isn't "take vitamin D" in the same list as "wash your hands often" and "keep distance"?

I've seen it recommended by some authorities, but very timidly. There's no single answer. Vitamin D is basically a panacea, but for some reason most medical professionals don't know. Modern western medicine is on the whole ignorant of the role of vitamin deficiencies in disease.

Doctors (and basically any degreed professional) aren't interested in recommending anything that doesn't involve them.

Re: Early clinical trial shows anti-depressant prevents hospitalization from Covid

#35

Post by mrob »

superkuh wrote: post #3

jamanetwork really needs to work on the accessibility of it's web design. Like most large online publishers of academic papers it recently made massive changes to it's journal sites so they're all javascript and CSS. Unlikely most large online publishers it hasn't realized what a mistake that was and implemented a fallback for content display in the absence of javascript execution. As is the page displays everything…

I agree it's terrible web design, but like many such cases, it can be fixed by enabling Firefox's Reader View.

Re: Early clinical trial shows anti-depressant prevents hospitalization from Covid

#36

Post by amelius »

mrfusion wrote: post #27
amelius wrote: post #20

Earlier quoted context omitted.

I believe the studies, but my question is why do we let the health system suffer if there is such a simple solution? Why isn't "take vitamin D" in the same list as "wash your hands often" and "keep distance"?

Are you sure the government cares about your health?

I'm sure they at least care about getting the economy back on track.

Re: Early clinical trial shows anti-depressant prevents hospitalization from Covid

#37

Post by nradov »

amelius wrote: post #10

Several months ago there was a post about vitamin D supposedly being effective in preventing hospitalization. What happened to that idea?

This site has a fairly complete index of all the studies about vitamin D and COVID-19. The total weight of evidence is now quite strong.

https://vitamin-d-covid.shotwell.ca/

Re: Early clinical trial shows anti-depressant prevents hospitalization from Covid

#38

Post by mlyle »

colossal wrote: post #19
JoshTko wrote: post #13

Earlier quoted context omitted.

Vitamin D has been shown to reduce severity in several different studies. Everyone should consider taking it. https://www.reddit.com/r/COVID19/search?q=vitamin+D&restrict... https://www.youtube.com/watch?v=vN30emwcNS4

It has shown to be correlated with better outcomes. It is also correlated with being healthier, being active, and eating better. As far as I understand there is no strong evidence for a causal relationship. To be clear, if you live in the northern hemisphere, you should be taking vitamin D. It's cheap and at worst harmless. But that's not the same as saying it will improve the outcome of covid patients.

IV calcifediol (Vitamin D) in early-stage COVID has improved outcomes in small randomized controlled trials.

Oral vitamin D has been shown to be ineffective at this point, but this isn't surprising: it takes a long time of sustained oral supplementation to raise levels.

Then there's a whole lot of evidence showing correlation, but as you point out, low vitamin D is an indicator of frailty. This is much weaker evidence.

I think it's likely that taking oral vitamin D before infection probably improves outcomes somewhat.

Re: Early clinical trial shows anti-depressant prevents hospitalization from Covid

#39

Post by LatteLazy »

Tiny study, just like chloroquine that is somehow still being talked about...

>Findings In this randomized trial that included 152 adult outpatients with confirmed COVID-19 and symptom onset within 7 days, clinical deterioration occurred in 0 patients treated with fluvoxamine vs 6 (8.3%) patients treated with placebo over 15 days, a difference that was statistically significant.

It honestly worries me how quick people are to jump on these band wagons. Call me when you've at least got 100 cases to review.

Re: Early clinical trial shows anti-depressant prevents hospitalization from Covid

#40

Post by amelius »

JoshTko wrote: post #34
lambdaba wrote: post #26

Earlier quoted context omitted.

I've seen it recommended by some authorities, but very timidly. There's no single answer. Vitamin D is basically a panacea, but for some reason most medical professionals don't know. Modern western medicine is on the whole ignorant of the role of vitamin deficiencies in disease.

Doctors (and basically any degreed professional) aren't interested in recommending anything that doesn't involve them.

The pandemic concerns the work and lives of just about any doctor at the moment.
Post reply on HN