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Human Ageing Reversed in ‘Holy Grail’ Study, Scientists Say

independent.co.uk

31–39 of 39 posts

Re: Human Ageing Reversed in ‘Holy Grail’ Study, Scientists Say

#31

Junk article. It's certainly not a "holy grail"...the study just measured telomere length after HBOT. Even meditation has been shown to reduce telomere length. It certainly didn't "reverse human aging". HN people: please stop posting these junk newspaper articles that completely misrepresent the science.

You mean meditation have been shown to increase telomeres' length, right?

Re: Human Ageing Reversed in ‘Holy Grail’ Study, Scientists Say

#32

Earlier quoted context omitted.

My guess is that the shortening of telomeres—and the presumed aging effects—is evolutionarily beneficial because it sets an expiration date on your life. If people could live forever they may prohibit other younger and genetically different people from reproducing and introducing variety in the gene pool. Certainly having wealthier people live forever now would be bad from a social perspective. Time is really the big…

With biomedical and technological advancements, this scenario is highly likely. At some point in the future, I can envision almost a divergence in human species - those who age naturally and live similar to how we do today, and those who’s wealth has afforded them medical and technical enhancements prolonging their lives, enhancing their abilities, and allowing them to control vast amounts of resources. Perhaps they…

The Netflix series Altered Carbon explores the idea of an immortal class. However, I can’t imagine that an advancement so compelling as immortality will not trickle down in some aspect. The majority of the developed world’s middle class benefits from initially complex and expensive technologies such as air travel, cancer treatment, and advanced computing — differences for the ultra-rich are marginal, not absolute.

Re: Human Ageing Reversed in ‘Holy Grail’ Study, Scientists Say

#33
Before anyone goes too nuts with this, keep in mind that your body is constantly evolving throughout your life via epigenetic suppression of certain genes. As you expose yourself to new bodily stresseors (regular exposure to a much more reactive atmosphere than normal) you may not be turning "back" aging, but rather reactivating old eukaryotic coping mechanisms evolved long ago, but not employed regularly since circumstances have changed. If you further cease to expose yourself to that stressor, your body will slowly shift away from utilizing those metabolic pathways back to something more efficient given the set of stressors in your typical environment.

Higher concentrations of oxygen from your respiratory system would likely signal the need in your entire body to upregulate cell division, due to oxidative stress both internal and external. It could also kick in metabolic processes that are not as efficient is substantially lower lower O2 partial pressure environments.

Nevermind the fire hazard. Pro-Tip: With enough 02 around, and nothing else to get in the way, everything burns with comparatively little inducement to do so.

Light reading https://www.eiga.eu/index.php?eID=dumpFile&t=f&f=208&token=c...

https://nj.gov/health/eoh/rtkweb/documents/fs/1448.pdf

There were a few other good searches I did long ago for another random walk of whimsy, but I seem to have lost track of them. I'll see if I can find them again.

Re: Human Ageing Reversed in ‘Holy Grail’ Study, Scientists Say

#34

I eagerly await the coming flood of DIY oxygen chamber tutorials. Hopefully no one gets hurt. FWIW: high concentration O2 is known to be toxic in other ways. It causes lung inflamation at least (oxygen is, after all, highly reactive and tends to break up lots of different molecules). I think there's a real possibility that this does more harm than good.

I think fire would be the most direct concern. IIRC, a lot of things become flammable in a high or pure O2 atmosphere that aren't normally considered flammable.

Re: Human Ageing Reversed in ‘Holy Grail’ Study, Scientists Say

#35
post #29
post #20

Earlier quoted context omitted.

Why would oxygen shortage lead to cell generation ? If I regularly choke myself, will I end up living longer ?

Hormesis is a fairly common theme in human biology. We seem to be at our best when under mild stressors.

> Hormesis has been observed in a number of cases in humans and animals exposed to chronic low doses of ionizing radiation. A-bomb survivors who received high doses exhibited shortened lifespan and increased cancer mortality, but at low-dose radiation the ratios of cancer deaths in A-bomb survivors are smaller than those of Japanese averages

(from Wikipedia)

I had never heard of hormesis before. Fascinating and a bit counter intuitive

Re: Human Ageing Reversed in ‘Holy Grail’ Study, Scientists Say

#36
post #5

Telomeres are intentionally shortened by the body, a process which is no doubt favored by evolution. While we don't know why for sure, it is entirely possible that telomere shortening actually lengthens life. As telomeres become shorter, cell division becomes slower and metabolism decreases. This means that an older person's cells will reproduce at a slower rate than a younger person's in general. If we suppose that…

Seems like pure speculation. There are a thousand different mechanisms that would explain it and would not mean "there is some health benefit". Is there a health benefit of white hair? Of wrinkles? Of ...? Quite the opposite seems true in fact. Evolution tries make us be on our peak at the reproductive age, and a lot of that happens after is a byproduct/consequence of this, not just for health benefits. Most (all?) o…

The white haired ones are for data storage not reproduction.

Re: Human Ageing Reversed in ‘Holy Grail’ Study, Scientists Say

#37

I eagerly await the coming flood of DIY oxygen chamber tutorials. Hopefully no one gets hurt. FWIW: high concentration O2 is known to be toxic in other ways. It causes lung inflamation at least (oxygen is, after all, highly reactive and tends to break up lots of different molecules). I think there's a real possibility that this does more harm than good.

Ozone (O3) is definitely the one that is very reactive and bad for your lungs.

Ozone is indeed acutely toxic. But no, plain O2 will attack pretty much anything (i.e. literally everything in your body can be "burned") with a reaction rate that depends on concentration. At a partial pressure of 0.2 bar, that's negligible, but it stops being so at some point.

It's a known thing in diving planning, here's a wikipedia article on it: https://en.wikipedia.org/wiki/Oxygen_toxicity

Now, I'm sure these chambers aren't at those pressures. But everything is likely linear, and the thing they're "curing" is literally what we currently consider to be the normal baseline! Even a very small effect will swamp whatever longevity benefits they're seeing are.

Re: Human Ageing Reversed in ‘Holy Grail’ Study, Scientists Say

#38

Junk article. It's certainly not a "holy grail"...the study just measured telomere length after HBOT. Even meditation has been shown to reduce telomere length. It certainly didn't "reverse human aging". HN people: please stop posting these junk newspaper articles that completely misrepresent the science.

You mean meditation have been shown to increase telomeres' length, right?

Yes, increase. Not able to edit my comment.

Re: Human Ageing Reversed in ‘Holy Grail’ Study, Scientists Say

#39
post #19

Earlier quoted context omitted.

The main outcome of the study was to measure an in improvement in cognition: https://www.aging-us.com/article/202188/text

There doesn't seem to be any mention of cognition as a result in the article. The primary endpoint was telomere length.

Sorry, that was a different study that they cite: "Cognitive enhancement of healthy older adults using hyperbaric oxygen: a randomized controlled trial" https://pubmed.ncbi.nlm.nih.gov/32589613/
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